A reservoir in Block A of an oil field is a new layer series in the new area, and a horizontal well has been deployed for the first time around the development of the target layer in the third section of the reservoir. Compared with the oil layers in the old area, the structure of the target layer in Block A is more complex, the reservoir changes rapidly, the prediction of sand-laden mud reservoir is difficult, and the tracking adjustment of horizontal wells while drilling is difficult. In view of the above problems, in order to ensure the drilling effect, we have carried out the basic geological research of the combination of well and earthquake, carried out the study of the correlation between rock and electricity and the combination of well and earthquake, carried out the multi-technology combination, innovatively formed the supporting technical methods of fine fault, micro-amplitude structure identification and reservoir prediction, established the fine three-dimensional geological model, optimized the well location and trajectory optimization design of favorable blocks, According to the technical process of “making plans before drilling, timely adjustment during drilling, and re-recognition after drilling”, 7 horizontal wells have been tracked and adjusted while drilling, with an average oil reservoir drilling rate of 85.3%, which has achieved good drilling results and increased geological reserves and productivity.