Prediction Algorithm Research Articles

Identification of positions in human aldolase a that are neutral for apparent KM

According to evolutionary theory, many naturally-occurring amino acid substitutions are expected to be neutral or near-neutral, with little effect on protein structure or function. Accordingly, most changes observed in human exomes are also expected to be neutral. As such, accurate algorithms for identifying medically-relevant changes must discriminate rare, non-neutral substitutions against a background of neutral substitutions. However, due to historical biases in biochemical experiments, the data available to train and validate prediction algorithms mostly contains non-neutral substitutions, with few examples of neutral substitutions. Thus, available training sets have the opposite composition of the desired test sets. Towards improving a dataset of these critical negative controls, we have concentrated on identifying neutral positions – those positions for which most of the possible 19 amino acid substitutions have little effect on protein structure or function. Here, we used a strategy based on multiple sequence alignments to identify putative neutral positions in human aldolase A, followed by biochemical assays for 147 aldolase substitutions. Results showed that most variants had little effect on either the apparent Michaelis constant for substrate fructose-1,6-bisphosphate or its apparent cooperativity. Thus, these data are useful for training and validating prediction algorithms. In addition, we created a database of these and other biochemically characterized aldolase variants along with aldolase sequences and characteristics derived from sequence and structure analyses. This database is publicly available at https://github.com/liskinsk/Aldolase-variant-and-sequence-database.

Performance of Atrial Fibrillation Burden Trends for Stroke Risk Stratification.

Atrial fibrillation (AF) is associated with an increased risk of stroke, yet the limitations of conventional monitoring have restricted our understanding of AF burden risk thresholds. Predictive algorithms incorporating continuous AF burden measures may be useful for predicting stroke. This study evaluated the performance of temporal AF burden trends as predictors of stroke from a large cohort with insertable cardiac monitors. Using deidentified data from Optum Clinformatics Data Mart (2007-2019) linked with the Medtronic CareLink insertable cardiac monitor database, we identified patients with an insertable cardiac monitor for AF management (n=1197), suspected AF (n=1611), and cryptogenic stroke (n=2205). Daily AF burden was transformed into simple moving averages, and temporal AF burden trends were defined as the comparison of unique simple moving average pairs. Classification trees were used to predict ischemic stroke, and AF burden significance was quantified using bootstrapped mean variable importance. Of 5013 patients (age, 69.2±11.7 years; 50% male; CHA2DS2-VASc, 3.7±1.9) who met inclusion criteria, 869 had an ischemic stroke over 2 409 437 days total follow-up. Prior stroke or transient ischemic attack (variable importance, 13.13) was the number 1 predictor of future stroke followed by no prior diagnosis of AF (7.35) and AF burden trends in follow-up (2.59). Temporal proximity of AF and risk of stroke differed by device indication (simple moving averages: AF management, <8 days and suspected AF and cryptogenic stroke, 8-21 days). Together, baseline characteristics and AF burden trends performed optimally for the area under the receiver operating characteristic curve (0.73), specificity (0.70), and relative risk (5.00). AF burden trends may provide incremental prognostic value as leading indicators of stroke risk compared with conventional schemes.

Development of a quantitative prediction algorithm for human cord blood-derived CD34+ hematopoietic stem-progenitor cells using parametric and non-parametric machine learning models

The transplantation of CD34+ hematopoietic stem-progenitor cells (HSPCs) derived from cord blood serves as the standard treatment for selected hematological, oncological, metabolic, and immunodeficiency disorders, of which the dose is pivotal to the clinical outcome. Based on numerous maternal and neonatal parameters, we evaluated the predictive power of mathematical pipelines to the proportion of CD34+ cells in the final cryopreserved cord blood product adopting both parametric and non-parametric algorithms. Twenty-four predictor variables associated with the cord blood processing of 802 processed cord blood units randomly sampled in 2020–2022 were retrieved and analyzed. Prediction models were developed by adopting the parametric (multivariate linear regression) and non-parametric (random forest and back propagation neural network) statistical models to investigate the data patterns for determining the single outcome (i.e., the proportion of CD34+ cells). The multivariate linear regression model produced the lowest root-mean-square deviation (0.0982). However, the model created by the back propagation neural network produced the highest median absolute deviation (0.0689) and predictive power (56.99%) in comparison to the random forest and multivariate linear regression. The predictive model depending on a combination of continuous and discrete maternal with neonatal parameters associated with cord blood processing can predict the CD34+ dose in the final product for clinical utilization. The back propagation neural network algorithm produces a model with the highest predictive power which can be widely applied to assisting cell banks for optimal cord blood unit selection to ensure the highest chance of transplantation success.

Analyzing Cryptographic Techniques and Machine Learning Algorithms for Crime Prediction

This report discusses cryptography techniques. Network security is defined as "keeping information hidden and secure from unauthorized users," whereas cryptography is defined as "the science of data protection." The Fundamental Requirements for Data Transmission are addressed in this work and as well as security attacks such as Data Transmission Interruption, Interception, and Modification. The Cryptographic Framework is explained using a generalized function, in which data is encrypted and decrypted using techniques such as the RSA algorithm, Hash Functions, and other cryptographic algorithms.SVM algorithms to analysis and predict the future cyber crime. This report introduces Cryptography Techniques. Cryptography is “The science of protecting data” &amp; Network Security “keeping information private and Secure from unauthorized Users”. This paper gives the Fundamental Requirements for the Data Transmission, the security attacks like Interruption, Interception and Modification of the data Transmission. Keywords—cryptography, cybersecurity, machine learning, cybercrime prediction

An error-corrected deep Autoformer model via Bayesian optimization algorithm and secondary decomposition for photovoltaic power prediction

Accurate PV power prediction is crucial for stable grid operation and rational dispatch. However, due to the instability of PV power generation, PV power prediction still has great challenges. Therefore, an Autoformer model based on secondary decomposition, Bayesian optimization and error correction for PV power prediction. In order to reduce the complexity of the data and fully extract the features, two decomposition methods are employed. First, empirical mode decomposition (EMD) is applied to decompose the PV power series at the first level. Then, the sample entropy (SE) is introduced to measure the complexity of each component, and the variational mode decomposition (VMD) is employed to implement secondary decomposition of the component with the highest complexity. Secondly, a Bayesian optimization algorithm enhanced Autoformer model is developed for predicting each component, and the predicted component results are aggregated to obtain preliminary PV power prediction results. Finally, the preliminary prediction results are error corrected using a least squares support vector machine. A four-month PV dataset from a PV power plant in Hangzhou, China is utilized to validate the effectiveness of the proposed model. The experimental results show that the model after primary decomposition is superior to the single model, and the prediction accuracy is substantially improved after secondary decomposition. The proposed model has the best prediction performance in predicting the PV power for different seasons, which shows good robustness.

Synergism of Computational Simulation Technique and Machine Learning Algorithm for Prediction of Anticorrosion Properties of Some Antipyrine Derivatives.

This study aimed to predict the selected antipyrine compounds' inhibitory efficiencies and anticorrosion properties in a hydrochloric acid (HCl) environment. Molecular descriptors and input variables were obtained using density functional theory (DFT), and the variance inflation factor (VIF) was employed to reduce redundant variables, leading to the selection of seven quantum chemical descriptors as input variables. Using machine learning techniques such as K-nearest neighbor (KNN) and artificial neural network (ANN), a predictive model was built for 39 antipyrine compounds with known corrosion inhibition efficiencies for carbon and low alloy steel in hydrochloric acid solutions. The models' predictive capability was assessed using cross-validation, with the ANN model showing superior performance, achieving a coefficient of determination (R2) value of 0.715 compared to 0.548 for the KNN model. Performance metrics such as the mean square error (MSE), mean absolute error (MAE), and root-mean-square error (RMSE) further confirmed the superiority of the ANN model over the KNN model. The corrosion inhibition efficiencies (CIEs) of the selected antipyrine compounds ranged from 68.78 to 99.79%, with compound A1 demonstrating the highest CIE of 99.79% and compound A3 the lowest, as evaluated by the ANN model. Analysis of Fukui index parameters obtained from the Mulliken population analysis suggested that the nucleophilic and electrophilic sites play a crucial role in the interactions between the inhibitor and the metal atom through electron donor-acceptor interactions. Moreover, the energy of adsorption (Eads) in kcal·mol-1 decreased in the order of A1 (-187.8) > A2 (-132.0) > A2 (-84.4), with the high negative value of Eads indicating strong and spontaneous adsorption. Further analysis using radial distribution functions and molecular dynamics simulations revealed that inhibitor A1 exhibited predominantly chemisorption, inhibitor A2 showed a mixed type, and inhibitor A3 demonstrated predominantly physisorption, aligning well with the results of the predictive studies.

Prediction of Capillary Pressure Curves Based on Particle Size Using Machine Learning

Capillary pressure curves are usually obtained through mercury injection experiments, which are mainly used to characterize pore structures. However, mercury injection experiments have many limitations, such as operation danger, a long experiment period, and great damage to the sample. Therefore, researchers have tried to predict capillary pressure data based on NMR data, but NMR data are expensive and unstable to obtain. This study aims to accurately predict capillary pressure curves. Based on rock particle size data, various machine learning methods, such as traditional machine learning and artificial neural networks, are used to build prediction models and predict different types of capillary pressure curves, aiming at studying the best prediction algorithm. In addition, through adjusting the amount of particle size characteristic data, the best amount of particle size characteristic data is explored. The results show that three correlation coefficients of the four optimal algorithms can reach more than 0.92, and the best performance is obtained using the Levenberg–Marquardt method. The prediction performance of this algorithm is excellent, with the three correlation coefficients being all higher than 0.96 and the root mean square error being only 5.866. When partial particle size characteristics are selected, the training performance is gradually improved with an increase in the amount of feature data, but it is far less than the performance of using all the features. When the interpolation increases the particle size characteristics, the best performance is achieved when the feature data volume is 50 groups and the root mean square error is the smallest, but the Kendall correlation coefficient decreases. This study provides a new way to obtain capillary pressure data accurately.

A machine-learning algorithm to grade heart murmurs and stage preclinical myxomatous mitral valve disease in dogs.

The presence and intensity of heart murmurs are sensitive indicators of several cardiac diseases in dogs, particularly myxomatous mitral valve disease (MMVD), but accurate interpretation requires substantial clinical expertise. Assess if a machine-learning algorithm can be trained to accurately detect and grade heart murmurs in dogs and detect cardiac disease in electronic stethoscope recordings. Dogs (n = 756) with and without cardiac disease attending referral centers in the United Kingdom. All dogs received full physical and echocardiographic examinations by a cardiologist to grade any murmurs and identify cardiac disease. A recurrent neural network algorithm, originally trained for heart murmur detection in humans, was fine-tuned on a subset of the dog data to predict the cardiologist's murmur grade from the audio recordings. The algorithm detected murmurs of any grade with a sensitivity of 87.9% (95% confidence interval [CI], 83.8%-92.1%) and a specificity of 81.7% (95% CI, 72.8%-89.0%). The predicted grade exactly matched the cardiologist's grade in 57.0% of recordings (95% CI, 52.8%-61.0%). The algorithm's prediction of loud or thrilling murmurs effectively differentiated between stage B1 and B2 preclinical MMVD (area under the curve [AUC], 0.861; 95% CI, 0.791-0.922), with a sensitivity of 81.4% (95% CI, 68.3%-93.3%) and a specificity of 73.9% (95% CI, 61.5%-84.9%). A machine-learning algorithm trained on humans can be successfully adapted to grade heart murmurs in dogs caused by common cardiac diseases, and assist in differentiating preclinical MMVD. The model is a promising tool to enable accurate, low-cost screening in primary care.

Carbon price prediction in China based on ensemble empirical mode decomposition and machine learning algorithms.

The carbon emission trading market is crucial for reducing emissions, conserving energy, and enhancing the climate and environment. Studying carbon price forecasting can encourage China's involvement in international carbon financial instruments trading and promote the development of China's pilot carbon markets. This study employs ensemble empirical mode decomposition (EEDM) to convert the initial carbon price, which is a non-stationary signal, into several intrinsic mode functions and residual terms. Subsequently, hybrid machine learning methods are used to estimate the carbon price. For empirical analysis, the three main carbon markets with large trading volumes, Guangdong, Hubei, and Shenzhen, are selected from the eight pilot carbon markets. To achieve short-term carbon price prediction, a hybrid model combining a genetic algorithm (GA) and back propagation (BP) neural network is used. This model effectively addresses the issue of neural networks falling into local optimization. The results indicate that the hybrid algorithm is significantly superior to other algorithms for short-term prediction. Additionally, another hybrid model, combining the least squares support vector machine (LSSVM) and particle swarm optimization (PSO) algorithms, is employed to reduce forecast error while minimizing search parameters, which is not possible with traditional neural network models.

A model predictive control algorithm for double-hormone artificial pancreas based on optimal three-branch decision switching rules

At present, double-hormone artificial pancreas is a hotspot in the research of regulating blood glucose level; however, there are few studies on switching mechanism of the subsystems for double-hormone artificial pancreas, and most of the existing studies rely on the prior knowledge of application fields. A model predictive control algorithm for double-hormone artificial pancreas based on optimal three-branch decision switching rules is proposed to solve this problem. The blood glucose controllers of insulin subsystems, zero infusion subsystems, and glucagon subsystems are constructed using model predictive control algorithms. Then, using the three-branch decision theory, switching rules between the three subsystems are designed, and the optimal switching threshold value can be solved by the mixed fruit fly algorithm. The algorithm can realize automatic acquisition of the threshold in the three-branch decision switching rules and gets rid of the dependence on the prior knowledge in the field of diabetes research. By the end, the UVa simulation platform is used to conduct experiments on 33 virtual patients and the simulation results verify that the proposed algorithm can control blood glucose effectively within the normal range and can achieve satisfactory performabce in error of tracking set point, safety, operation efficiency, group control quality, and system stability.

Molecular spectral line data preprocessing container load grouping prediction algorithm based on EMD-LSTM

Unbalanced allocation of container resources in cluster environments is an urgent problem to be solved. Aiming at container load prediction and resource allocation strategy, this paper designs an astronomical data processing container load grouping prediction algorithm based on empirical mode decomposition-long short-term memory network, and proposes an adaptive recommendation value generation algorithm based on predicted load information, which can automatically allocate container computing resources according to the degree of load fluctuation. The load prediction accuracy is verified using simulated data and real astronomical observation data. The experimental results show that the algorithm proposed in this paper has higher prediction accuracy than the triple index method and the single long short-term memory network model. In the real-time preprocessing test of astronomical data, the recommendation value generation algorithm proposed in this paper can effectively improve the utilization efficiency of computing resources compared with the default strategy.

Data-Driven Sparse Sensor Placement Optimization on Wings for Flight-By-Feel: Bioinspired Approach and Application.

Flight-by-feel (FBF) is an approach to flight control that uses dispersed sensors on the wings of aircraft to detect flight state. While biological FBF systems, such as the wings of insects, often contain hundreds of strain and flow sensors, artificial systems are highly constrained by size, weight, and power (SWaP) considerations, especially for small aircraft. An optimization approach is needed to determine how many sensors are required and where they should be placed on the wing. Airflow fields can be highly nonlinear, and many local minima exist for sensor placement, meaning conventional optimization techniques are unreliable for this application. The Sparse Sensor Placement Optimization for Prediction (SSPOP) algorithm extracts information from a dense array of flow data using singular value decomposition and linear discriminant analysis, thereby identifying the most information-rich sparse subset of sensor locations. In this research, the SSPOP algorithm is evaluated for the placement of artificial hair sensors on a 3D delta wing model with a 45° sweep angle and a blunt leading edge. The sensor placement solution, or design point (DP), is shown to rank within the top one percent of all possible solutions by root mean square error in angle of attack prediction. This research is the first to evaluate SSPOP on a 3D model and the first to include variable length hairs for variable velocity sensitivity. A comparison of SSPOP against conventional greedy search and gradient-based optimization shows that SSPOP DP ranks nearest to optimal in over 90 percent of models and is far more robust to model variation. The successful application of SSPOP in complex 3D flows paves the way for experimental sensor placement optimization for artificial hair-cell airflow sensors and is a major step toward biomimetic flight-by-feel.

Comparison of Arima Model with The Addition of Linear Quadratic Estimation Algorithm for Prediction The Spread of Covid-19 in Kotabaru District

Comparison of Arima Model with The Addition of Linear Quadratic Estimation Algorithm for Prediction The Spread of Covid-19 in Kotabaru District

Research on Momentum prediction algorithm for athletes based on the CNN-LSTM Model

Momentum has been widely recognized as a psychological factor affecting athletes' performance during sports events. Quantifying the momentum of both athletes in a match and predicting its future trends and reversals can provide effective information for coaches to make tactical decisions during a match. In this paper, taking the Wimbledon dataset as an example, the quantitative model of momentum is firstly constructed by the rank-sum-ratio evaluation method based on EWMA. Subsequently, this paper introduces the CNN network to process the data input based on the traditional LSTM network, takes the output data of the CNN network as the input layer of the LSTM network, and constructs a CNN-LSTM model to predict the change of momentum of athletes in the match, and the reversal time of momentum of athletes of both sides points. Through the model comparison analysis, this paper found that the prediction accuracy of the CNN-LSTM in different time periods is up to 85%, surpassing the LSTM network by 10%. This paper helps coaches and athletes to identify the future trend of momentum in the course of the match so that they can make reasonable tactical arrangements to achieve better performance in sports events.

A traffic speed prediction algorithm for dynamic spatio-temporal graph convolutional networks based on attention mechanism

A traffic speed prediction algorithm for dynamic spatio-temporal graph convolutional networks based on attention mechanism

The Moderating Effect of Population Growth on the Relationship between Carbon Emission and Economic Development in Surigao Del Norte, Philippines using Predictive Algorithm

This paper explored the moderating effect of population growth on the relationship between carbon emissions and economic development in Surigao del Norte. The descriptive research design of the study has been complemented by data mining techniques in the analysis of the gathered data. The results revealed that the trend of population growth, economic growth, and carbon emission in Surigao del Norte from 2019-2022 were fluctuating based on pre- and post-pandemic effects as well as increased economic activities, industrial growth, and changes in energy consumption patterns. Moreover, the forecasted trend of population growth, economic development, and carbon emission in the next decade is also fluctuating based on the data but notable increase in the population growth for the province will significantly be seen and since the forecasted trend of population growth, economic growth, and carbon emission is fluctuating, it does have a significant contribution to the Philippines population growth, economic development, and carbon emission in the next decade. Consequently, the economic development in the province of Surigao del Norte poses a significant impact towards the province’s carbon emission in the next years and lastly the population growth of Surigao del Norte has a significant and positive influence towards the economic development of the province and its corresponding carbon emissions in the next years.

Machine learning based tuberculosis (ML-TB) health predictor model: early TB health disease prediction with ML models for prevention in developing countries

Background Tuberculosis (TB) remains one of the top infectious killers in the world and a prominent fatal disease in developing countries. This study proposes a prototypical solution to early prevention of TB based on its primary symptoms, signs, and risk factors, implemented by means of machine learning (ML) predictive algorithms. Further novelty of the study lies in the uniqueness of patient dataset collected from three top-ranked hospitals of Sindh, Pakistan, via a self-administered survey patient-records that comprises a set of questions asked by the doctors treating TB patients in real-time. A total of 1,200 survey patient-records were evenly distributed among all three hospitals, viz. ICT Kotri, LUMHS Jamshoro, and Civil Hospital Hyderabad. Methods To develop the required prototypes, the research made use of five distinct benchmark ML algorithms: decision tree (DT), Gaussian naive Bayes (GNB), logistic regression classifier (LRC), adaptive boosting (AdaBoost), and neural network (NN), whose performance was evaluated by considering various performance metrics, i.e., accuracy, precision, recall, F1 score, and confusion matrix. Results The experimental results, graphically visualized and systematically discoursed, demonstrate that early detection of TB classifiers, including DT, GNB, LRC, AdaBoost, and NN, attained accuracy rates of 92.11%, 89.04%, 90.35%, 93.42%, and 92.98%, respectively. These results indicate effective diagnosis of TB disease by each implemented ML algorithm.

Machine learning algorithms to predict treatment success for patients with pulmonary tuberculosis.

Despite advancements in detection and treatment, tuberculosis (TB), an infectious illness caused by the Mycobacterium TB bacteria, continues to pose a serious threat to world health. The TB diagnosis phase includes a patient's medical history, physical examination, chest X-rays, and laboratory procedures, such as molecular testing and sputum culture. In artificial intelligence (AI), machine learning (ML) is an advanced study of statistical algorithms that can learn from historical data and generalize the results to unseen data. There are not many studies done on the ML algorithm that enables the prediction of treatment success for patients with pulmonary TB (PTB). The objective of this study is to identify an effective and predictive ML algorithm to evaluate the detection of treatment success in PTB patients and to compare the predictive performance of the ML models. In this retrospective study, a total of 1236 PTB patients who were given treatment under a randomized controlled clinical trial at the ICMR-National Institute for Research in Tuberculosis, Chennai, India were considered for data analysis. The multiple ML models were developed and tested to identify the best algorithm to predict the sputum culture conversion of TB patients during the treatment period. In this study, decision tree (DT), random forest (RF), support vector machine (SVM) and naïve bayes (NB) models were validated with high performance by achieving an area under the curve (AUC) of receiver operating characteristic (ROC) greater than 80%. The salient finding of the study is that the DT model was produced as a better algorithm with the highest accuracy (92.72%), an AUC (0.909), precision (95.90%), recall (95.60%) and F1-score (95.75%) among the ML models. This methodology may be used to study the precise ML model classification for predicting the treatment success of TB patients during the treatment period.

Modeling the Dynamics of Prosthetic Fingers for the Development of Predictive Control Algorithms

In the field of biomechanical modeling, the development of a prosthetic hand with dexterity comparable to the human hand is a multidisciplinary challenge involving complex mechatronic systems, intuitive control schemes, and effective body interfaces. Most current commercial prostheses offer limited functionality, typically only one or two degrees of freedom (DoF), resulting in reduced user adoption due to discomfort and lack of functionality. This research aims to design a computationally efficient low-level control algorithm for prosthetic hand fingers to be able to (a) accurately manage finger positions, (b) anticipate future information, and (c) minimize power consumption. The methodology employed is known as model-based predictive control (MBPC) and starts with the application of linear identification techniques to model the system dynamics. Then, the identified model is used to implement a generalized predictive control (GPC) algorithm, which optimizes the control effort and system performance. A test bench is used for experimental validation, and the results demonstrate that the proposed control scheme significantly improves the prosthesis’ dexterity and energy efficiency, enhancing its potential for daily use by people with hand loss.

Use of continuous glucose monitoring and hybrid closed-loop therapy in pregnancy.

Continuous glucose monitoring (CGM) has led to a paradigm shift in the management of pregnant women with type 1 diabetes (T1D), with improved glycaemic control, less hypoglycaemia and fewer pregnancy complications. Data on CGM use in pregnant women with type 2 diabetes (T2D) are limited. A large randomized controlled trial (RCT) on CGM use in people with T2D in pregnancy is ongoing. Small studies on CGM use in women with gestational diabetes (GDM) have suggested improved glycaemic control and better qualification when insulin is needed. However, none of these studies was powered to evaluate pregnancy outcomes. Several large RCTs are ongoing in women with GDM. In addition to CGM, other technologies, such as advanced hybrid closed-loop (AHCL) systems have further improved glycaemic management in people with T1D. AHCL therapy adapts insulin delivery via a predictive algorithm integrated with CGM and an insulin pump. A large RCT with the AHCL CamAPS® FX demonstrated a 10% increase in time in range compared to standard insulin therapy in a pregnant population with T1D. Recently, an RCT of an AHCL system not approved for use in pregnancy (780G MiniMed) has also demonstrated additional benefits of AHCL therapy compared to standard insulin therapy, with improved time in range overnight, less hypoglycaemia and improved treatment satisfaction. More evidence is needed on the impact of AHCL therapy on maternal and neonatal outcomes and on which glycaemic targets with CGM should be used in pregnant women with T2D and GDM. We review the current evidence on the use of CGM and AHCL therapy in pregnancy.