This paper investigates the buckling behaviour and load-carrying capacity of G550 high strength cold-formed steel built-up section columns under axial compression through experiments and numerical simulations. Two types of built-up sectional profiles were formed, which were defined as built-up OI-section and built-up CB-section. Each built-up OI-section member is formed by connecting two cold-formed steel C-section members in a back-to-back manner using self-drilling screws, while each built-up CB-section member consists of a cold-formed steel C-section member and a cold-formed steel U-section member, which are connected in a face-to-face manner by self-drilling screws. The experimental programme included tensile coupon tests, initial geometric imperfection measurements and 20 pin-ended column compression tests. In the numerical modelling programme, finite element models were developed and validated against the experimental results, and then used for parametric analyses to generate a total of 250 numerical data with different cross-section dimensions and member lengths. Based on the experimental and numerical data, the accuracy of both the effective width method and the direct strength method for predicting the strengths of G550 high strength cold-formed steel built-up section columns, as set out in the American Specification, was evaluated. The evaluation results indicated that both the effective width method and direct strength method provided accurate and consistent failure load predictions for G550 high strength cold-formed steel built-up OI-section columns on average, but with some unsafe failure load predictions, while the predicted failure loads were inaccurate, scattered and conservative for G550 high strength cold-formed steel built-up CB-section columns. Moreover, the effective width method and direct strength method yielded a similar level of design consistency for G550 cold-formed steel built-up section columns, but the direct strength method resulted in more accurate and less conservative failure load predictions than the effective width method. The modifications to the codified DSM equations were proposed for G550 high strength cold-formed steel built-up section columns and shown to provide improved predictions of failure load over the design codes.