Penicillin Precursors Research Articles

Penicillin Coprecursorに関する研究(第3報)

In the previous report, the addition of H2C (S•CH2C00H)2 together with penicillin precursors into penicillin culture broth, can increase or accelerate penicillin production and sometimes enhance penicillin G-content of the broth, comparing with the cases when only penicillin-G precursors are added. (We named such a compound “penicillin coprecursor”.) In this report, the coprecursor activities of various compounds having analogous structure to CH2(S. CH2COOH)2 are studied. a, _??_manifests strong coprecursor activity when phenylacetic acid or phenylacetamide is added as the precursor. The amount and mode of addition of this substance have only small influence on the efficiency as the coprecursor. b._??_too, seems to have some coprecursor activity, but result obtained is not so clear as its free acid. c._??_has some coprecursor activity, But, as this substance is somewhat toxic to Penicillium, the amount and mode of addition should be determined carefully to ensure its coprecursor effect. d._??_too, seems to have some coprecursor effect. e._??_and _??_also mainfest some coprecursor activity, but_??_indicates no activity._??_seems to have moderate coprecursor activity. Generally speaking, compo. unds which have the structure_??_in the molecules, often possess the coprecursor activity. (R1 R2……Hydrogen atom or aliphatic radical)

Evaluation of esters of phenylacetic acid as precursors of penicillin G

Twenty-eight esters of phenylacetic acid were prepared and tested as precursors of penicillin G. The higher alkyl esters and the diesters of certain glycols were found to be equivalent to or better than β-phenylethylamine.

5-Substituted 2-Thiopheneacetic Acids and Amides as Penicillin Precursors

5-Substituted 2-Thiopheneacetic Acids and Amides as Penicillin Precursors

Biosynthesis of Penicillins. V.1 Substituted Phenylacetic Acid Derivatives as Penicillin Precursors

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of Penicillins. V.1 Substituted Phenylacetic Acid Derivatives as Penicillin PrecursorsJoseph W. Corse, Reuben G. Jones, Quentin F. Soper, Calvert W. Whitehead, and Otto K. BehrensCite this: J. Am. Chem. Soc. 1948, 70, 9, 2837–2843Publication Date (Print):September 1, 1948Publication History Published online1 May 2002Published inissue 1 September 1948https://doi.org/10.1021/ja01189a001RIGHTS & PERMISSIONSArticle Views539Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (831 KB) Get e-Alerts Get e-Alerts