At present, removable partial denture is still one of the main restoration methods for dentition defects. However, the trend for digital partial denture is becoming more and more obvious in the field of oral repair. However, there are relatively few studies on digital removable partial denture. The aim of this study is to investigate the effects of 3 processing technologies (precision casting, digital cutting, and 3D printing) on the fitness for the clasps of cobalt chromium alloy and pure titanium removable partial denture, and to provide a theoretical basis for the clinical application of digital removable partial denture. Clasps of Co-Cr alloy and pure titanium were produced by 3 different processing technologies (precision casting, digital cutting, and 3D printing). There are 6 groups, including a casting pure titanium group, a casting cobalt chromium group, a cutting pure titanium group, a cutting cobalt chromium group, a printing pure titanium group, and a printing cobalt chromium group (n=6 per group). The gaps between the initial, middle, and tip of the lingual opposing arm of the clasp and the abutment were measured by fluorescent microscope, and the average value was taken as the index to measure the fitness between the clasp and the abutment. The fitness difference in three-arm clasp made of cobalt chromium alloy and pure titanium materials under 3 different technologies was compared. There was no statistical difference in fitness between the casting pure titanium group and the casting cobalt chromium group (P>0.05); there was no statistical difference in fitness between the cutting pure titanium group and the cutting cobalt chromium group (P>0.05); there was no statistical difference in fitness between the printing pure titanium group and the printing cobalt chromium group (P>0.05). When pure titanium was used, the fitness of the printing pure titanium group was the best (both P<0.05). There was no significant difference between the casting pure titanium group and the cutting pure titanium group (P>0.05). When cobalt chromium alloy was used, there was no significant difference in fitness among the 3 groups (P>0.05). The cobalt chromium alloy and pure titanium clasps made by precision casting, digital cutting, and 3D printing have good fitness. Under the same process, there is no significant difference between cobalt chromium alloy and pure titanium clasps. The 3D printing pure titanium clasps have better fitness than casting pure titanium and cutting pure titanium clasps, which meet the needs of clinical application.