Preschool Age Research Articles

Assessment of Milk and Beverage Intake Trends During Preschool Age and Modeling the Nutritional Impact of Replacing Nondairy Caloric Beverages with Milk

BackgroundMilk provides essential crucial public health nutrients, including 3–4 nutrients of public health concern, yet dairy consumption has declined over time, leading most Americans to fall short of meeting Dietary Guidelines recommendations. ObjectivesTo investigate milk and beverage consumption trends in preschool-age children, along with nutrient intakes from beverages, and to analyze the potential impact of replacing nondairy beverages with milk through isocaloric substitution. MethodsData from the National Health and Nutrition Examination Survey 2001–2018 for children aged 1–5 y (n = 4696) were used, and milk and other beverages intakes were estimated from the first 24-h in-person dietary recall. Nutrient intakes were determined using the United States Department of Agriculture’s food and nutrient database for dietary studies. Changes in nutrient intakes of children aged 2–5 y were modeled assuming isocaloric substitution with milk of all nondairy beverages consumed during lunch and dinner combined. Sample-weighted analyses were performed using SAS 9.4, and significance was set at P < 0.01. ResultsWith the increasing age of children, the intake of milk decreased, whereas the intake of energy, caloric beverages excluding milk, and sugar-sweetened beverages increased. Daily intakes of energy, protein, fat, saturated fatty acids (SFA), calcium, magnesium, potassium, sodium, vitamin A, folate, vitamin B-12, and vitamin D from caloric beverages including milk decreased with age, whereas the daily intake of fiber and added sugar increased with age. With the isocaloric replacement of nondairy caloric beverages with milk at lunch and dinner among children aged 2–5 y, intake of protein, fat, SFAs, calcium, magnesium, potassium, sodium, vitamin A, folate, vitamin B-12, and vitamin D increased, whereas for intake of carbohydrate, fiber, total sugar, and added sugar decreased. ConclusionsThe current findings indicate that increased efforts are needed to reverse the decrease in milk intake over time and as preschool children age and provide additional evidence to support specific dietary recommendations for milk.

Bilirubin metabolism in early life and respiratory health during preschool age: A combined analysis of two independent birth cohorts.

Bilirubin has antioxidant properties, and elevated levels within the normal range have been associated with improved lung function and decreased risk of asthma in adults, but studies of young children are scarce. Here, we investigate associations between bilirubin in early life and respiratory health endpoints during preschool age in two independent birth cohorts. Bilirubin metabolites were assessed at ages 0.5, 1.5, and 6 years in COPSAC2010 (Copenhagen Prospective Studies on Asthma in Childhood 2010) and ages 1, 3, and 6 years in the VDAART (The Vitamin D Antenatal Asthma Reduction Trial) cohort. Meta-analyses were done to summarize the relationship between levels of bilirubin metabolites and asthma, infections, lung function, and allergic sensitization until age 6 across the cohorts. Interaction with the glucuronosyltransferase family 1 member A1 (UGT1A) genotype encoding for an enzyme in the bilirubin metabolism was explored, and metabolomics data were integrated to study underlying mechanisms. Increasing bilirubin (Z,Z) at ages 1.5-3 years was associated with an increased risk of allergic sensitization (adjusted relative risk [aRR]= 1.85 [1.20-2.85], p= 0.005), and age 6 bilirubin (Z,Z) also showed a trend of association with allergic sensitization at age 6 (aRR= 1.31 [0.97-1.77], p= 0.08), which showed significant interaction for the age 6 bilirubin (Z,Z)xUGT1A genotype. Further, increasing bilirubin (E,E), bilirubin (Z,Z), and biliverdin at ages 1.5-3 years was associated with a lower forced expiratory volume at age 6 (aRRrange= 0.81-0.91, p<0.049) but without a significant interaction with the UGT1A genotype (pinteractions>0.05). Network analysis showed a significant correlation between bilirubin metabolism and acyl carnitines. There were no associations between bilirubin metabolites and the risk of asthma and infections. Bilirubin metabolism in early life may play a role in childhood respiratory health, particularly in children with specific UGT1A genotypes. The Lundbeck Foundation (Grant no R16-A1694), The Ministry of Health (Grant no 903516), Danish Council for Strategic Research (Grant no 0603-00280B), and The Capital Region Research Foundation have provided core support to the COPSAC research center. This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No. 946228). The Vitamin D Antenatal Asthma Reduction Trial (VDDART, ClinicalTrials.gov identifier: NCT00920621) was supported by grant U01HL091528 from NHLBI, U54TR001012 from the National Centers for Advancing Translational Sciences (NCATS). Metabolomics work by VDAART was supported by the National Heart, Lung, and Blood Institute (NHLBI) grant R01HL123915 and R01HL141826. S.T.W. was supported by R01HL091528 from the NHLBI, UG3OD023268 from Office of The Director, National Institute of Health, and P01HL132825 from the NHLBI.

Structural Equality and Support Index in Early Childhood Education

Whether early childhood education is associated with a wide range of adult outcomes above and beyond individual- and family-level outcomes is unknown. As a consequence of improving educational and career success, it is postulated that participation in high quality, comprehensive programs can promote residence in more supportive community contexts in adulthood. To investigate whether participation in high-quality early childhood programs (ECP) in high-poverty neighborhoods is associated with neighborhood-level social determinants of health (SDH) at midlife. This cohort study analyzed data from the Chicago Longitudinal Study, a prospective cohort investigation following-up 989 children aged 3 to 4 years attending the Child-Parent Center (CPC) preschool program between 1983 and 1985 and a comparison group of 550 children using a nonrandomized trial design. Participants from the original sample who completed a telephone interview on health and well-being between ages 32 and 37 years were included in this analysis. Data analysis was conducted from April to June 2024. Participation in a CPC program, which includes preschool (ages 3 to 4 years) and school-age (kindergarten through third grade), vs usual early education programs. The study used a new SDH measure (Index of Structural Equality and Support [I-SES]) based on the Healthy People 2030 framework. This 9-item index score included neighborhood-level assessment, measurement of the quality of education and health services, and assessment of racial discrimination in social and community contexts. Years of education by age 34 years was assessed as the key mediator of influence. A total of 1124 individuals (mean [SD] age at survey completion, 34.9 [1.4] years; 614 women [54.6%]; 1054 non-Hispanic Black [93.8%]; 69 Hispanic [6.2%]; 1 non-Hispanic White [<0.1%]) were included in the study, of whom 740 were in the CPC cohort and 384 were in the comparison cohort. After adjustment for baseline attributes and attrition, compared with no CPC preschool, CPC preschool was associated with significantly higher mean (SD) I-SES scores (5.93 vs 5.53; mean difference, 0.40; 95% CI, 0.16-0.65; standardized mean difference = 0.22). Compared with CPC participation for 0 to 3 years, CPC participation for 4 to 6 years showed a similar pattern of positive associations (adjusted mean I-SES score, 5.97 vs 5.69; mean difference, 0.28; 95% CI, 0.06-0.50; P = .01; SMD = 0.15). CPC participation had a larger-magnitude association with I-SES in married vs single-parent households. Years of education partially mediated the association of CPC with I-SES (up to 41%), especially among those growing up in the highest-poverty neighborhoods. This cohort study found that early childhood programming is associated with SDH in adulthood. These findings reinforce the importance of early childhood education in addressing health disparities and contributing to healthier, more equitable communities and suggest that educational attainment is a key mechanism for health promotion.

СЦЕНАТА КАТО МЯСТО ЗА СЪТРУДНИЧЕСТВО И УСВОЯВАНЕ НА УМЕНИЯ ЗА ЖИВОТА

The report examines an experimental experience of cooperation between the ‘Bratya Grimm’ kindergarten and students from NBU, Theater Department during the ‘Bratya Grimm’ International Fairy Tale Festival in Shumen in April 2024. Literary sources show the importance of theater for children of preschool age, the possibilities for emotional, mental and physical development. The role of art as a means and method of learning is also described. Aspects of cooperation and interaction that develop the skills of both participating parties – students and children – are presented, as well as factors infl uencing this cooperation. The benefits and questions left after the experiment from the perspective of teachers, students and children are listed. opportunities for development in this direction of interaction in theatrical forms between adults and children on stage have been identified.

Hubungan Pola Asuh Orang Tua dengan Perkembangan Sosial Emosional Anak Pra Sekolah di PAUD Surya Ceria Aisyiyah Kabupaten Karanganyar

The preschool period is an important period in a child's development, because not all children can go through a period of optimal growth and development. World Health Organization (WHO) 2019, reported that 5-25% of preschool age children experience emotional development disorders with a child population of 23,979,000. Parental parenting patterns really help children achieve normal growth and development according to their age level. The aim of this research is to determine the relationship between parental parenting patterns and the social emotional development of preschool children at PAUD Surya Ceria Aisyiyah Karanganyar. This research method is correlational analytical with a cross sectional approach. The population of this study was 60 people with sampling using the total sampling technique. The results showed that the majority of mothers implemented democratic parenting as many as 48 (80.0%) and the majority of preschool children had very good social emotional development as many as 44 (73.3%). ) preschool children. The data was processed using the chis square test with a value of r value = 0.00 so it can be interpreted that there is a relationship between parenting patterns and the social emotional development of preschool children. Conclusion: Each parent has a different parenting style and each parenting pattern can shape the child's social emotional development differently.

Private Tutoring as a Relief or Burden? Changes in Parental Beliefs About Young Children's English Learning in China

AbstractThe increasing trend of early English education has promoted the rapid growth of English private tutoring (EPT) for children, which garners attention in research as a global educational phenomenon. In China, EPT for children experienced a fervent expansion under neoliberalism. However, a recent policy (Double‐Reduction Policy) has banned EPT for preschoolers (age 3–6), creating a unique context where state‐led neoliberalism prevails. This study employs narrative inquiry to investigate the changes in beliefs about young children's English learning among three Chinese parents who enrolled their children in EPT. Data were gleaned through interviews, observations, informal conversations, and collection of parent‐recorded videos and artifacts over a year of fieldwork. The findings reveal that parents hold contradictory beliefs at different times, and the belief changes were interacted inextricably with the tensions experienced by these parents, including pressure from EPT and challenges from the policy. EPT was initially perceived as relief but eventually became burdensome. This study sheds light on the dynamic and intricate nature of parental beliefs, as well as the tensions arising from the interplay between neoliberalism and policy shifts in China. The findings have implications for parents, TESOL practitioners, and policymakers who involved in English education decisions for young children.

Specifics of transformative education for children of preschool and primary school age within the framework of continuity of educational programs

Specifics of transformative education for children of preschool and primary school age within the framework of continuity of educational programs

Penerapan Terapi Bermain Boneka Tangan terhadap Tingkat Kecemasan Hospitalisasi pada Anak Usia Prasekolah di RSUD Ir. Soekarno Kabupaten Sukoharjo

Hospitalization anxiety experienced by preschool children causes an increase in anxiety due to actions that cause trauma, children's hand puppets can explore the feelings they are experiencing. Objective: To determine the results of the implementation of hand puppet play therapy on the level of hospitalization anxiety in preschool children at the Ir. Soekarno Sukoharjo Regional Hospital. Method: This study used 2 respondents according to the inclusion and exclusion criteria, the method used pre-test and post-test, by providing hand puppet play therapy for 2 days carried out once a day for 30 minutes. Results: Results of the implementation of hand puppet play on hospitalization anxiety in preschool age children on day 1 of An. A got a score of 37 in the heavy category and An. B got a score of 28 in the heavy category. On the 2nd day on An. A got a score of 25 in the medium category and An. B got a score of 15 in the light category. Where the two patients before application were at a severe anxiety score and experienced a decrease in anxiety scores to moderate and mild. Conclusion: Hand puppet play therapy can reduce anxiety levels in children with hospitality.

The predictive value of peripheral blood cell mitochondrial gene expression in identifying the prognosis in pediatric sepsis at preschool age.

Sepsis represents a severe manifestation of infection often accompanied by metabolic disorders and mitochondrial dysfunction. Notably, mitochondrial DNA copy number (mtDNA-CN) and the expression of specific mitochondrial genes have emerged as sensitive indicators of mitochondrial function. To investigate the utility of mitochondrial gene expression in peripheral blood cells for distinguishing severe infections and predicting associated outcomes, we conducted a prospective cohort study. We established a prospective cohort comprising 74 patients with non-sepsis pneumonia and 67 cases of sepsis induced by respiratory infections, aging from 2 to 6 years old. We documented corresponding clinical data and laboratory information and collected blood samples upon initial hospital admission. Peripheral blood cells were promptly isolated, and both total DNA and RNA were extracted. We utilized absolute quantification PCR to assess mtDNA-CN, as well as the expression levels of mt-CO1, mt-ND1, and mt-ATP6. Subsequently, we extended these comparisons to include survivors and non-survivors among patients with sepsis using univariate and multivariate analyses. Receiver operating characteristic (ROC) curves were constructed to assess the diagnostic potential. The mtDNA-CN in peripheral blood cells was significantly lower in the sepsis group. Univariate analysis revealed a significant reduction in the expression of mt-CO1, mt-ND1, and mt-ATP6 in patients with sepsis. However, multivariate analysis did not support the use of mitochondrial function in peripheral blood cells for sepsis diagnosis. In the comparison between pediatric sepsis survivors and non-survivors, univariate analysis indicated a substantial reduction in the expression of mt-CO1, mt-ND1, and mt-ATP6 among non-survivors. Notably, total bilirubin (TB), mt-CO1, mt-ND1, and mt-ATP6 levels were identified as independent risk factors for sepsis-induced mortality. ROC curves were then established for these independent risk factors, revealing areas under the curve (AUCs) of 0.753 for TB (95% CI 0.596-0.910), 0.870 for mt-CO1 (95% CI 0.775-0.965), 0.987 for mt-ND1 (95% CI 0.964-1.000), and 0.877 for mt-ATP6 (95% CI 0.793-0.962). MtDNA-CN and mitochondrial gene expression are closely linked to the severity and clinical outcomes of infectious diseases. Severe infections lead to impaired mitochondrial function in peripheral blood cells. Notably, when compared to other laboratory parameters, the expression levels of mt-CO1, mt-ND1, and mt-ATP6 demonstrate promising potential for assessing the prognosis of pediatric sepsis.

A comparative study of early childhood education and care national documents between China and Finland

Early childhood education and care (ECEC) serves as a crucial foundation for children’s holistic growth and lifelong learning. Despite its significance, comparative analyses of leading ECEC documents across cultures remain limited. To address this gap, our study conducts a comparative analysis to identify key aspects and examine similarities and differences in national ECEC documents from China and Finland. Methodologically, we used a triangle of researchers from China and Finland. We employed qualitative content analysis to systematically identify, examine, and compare the key aspects in these two countries from the leading ECEC documents, i.e., the Chinese national ECEC guidelines and the Finnish ECEC national core curriculum. The findings reveal numerous similarities alongside notable differences. Both countries place a high value on ECEC, emphasizing principles that shape the learning environment and use diverse pedagogical methods. However, nuanced variations exist in the approaches. The Chinese documents feature more specific guidelines tailored to different age groups, accompanied by detailed pedagogical suggestions, while the Finnish national core curriculum offers general guidelines for all preschool age groups, complemented by the unique feature of individual development plans for each child. The findings have significant implications for policymakers, ECEC educators, and practitioners in international contexts. Future studies are needed to further explore the specific pedagogies in ECEC between these two nations and to analyze how the curriculum and educational guidelines are implemented in pedagogical practices.

Имплицитное понимание неверных мнений: современное состояние исследований

&lt;p style="text-align: justify;"&gt;The article presents a review of a number of modern foreign studies of implicit false beliefs in young children with typical development, hearing impairments, autism spectrum disorders, and primates. The results of studies performed using different methodological paradigms for assessing early development of mental models: violation of expectations and anticipatory looking are analyzed. The results of research on the search for the biological basis of the origins of social cognition using functional near-infrared spectroscopy are presented, as well as the results of research on the relationship between possible predictors of theory of mind (understanding the purpose of another's actions, joint attention, implicit false beliefs) and the success of social cognition in preschool age under typical development. Theoretical conceptualizations of two theory of mind systems are described: the minimal one and the theory of mind. Immediate prospects for future research to resolve existing replication crises and prevent new ones are outlined.&lt;/p&gt;

The Development of Gesture Skills in Chinese Autistic Children: The Predictive Roles of Age and Language Ability.

Gesture delay in autistic infants and toddlers has been widely reported. The developmental trajectory of gesture production during early childhood is understudied. Thus, little is known about the possible changes of gesture production over time. The present study aimed to document the development of gesture production in autistic children and examine whether child-based factors (chronological age and initial language skills) predicted gesture development. A total of 33 Chinese-speaking autistic children (Mage = 56.39 months, SD = 8.54 months) played with their parents at four time points over a 9-month period. Their speech was transcribed, and their gestures were coded from parent-child interaction. Multilevel modeling analysis was used to investigate the development of gesture and its associated factors. The total number of gestures produced by autistic children decreased over time. Among different factors, children's initial age significantly and negatively predicted children's gesture production, while initial language positively predicted children's gesture production. Gesture delay persists in preschool age. The decline in gesture production was associated with children's age and initial language ability. These findings shed light on the difficulties surrounding gesture use in autistic children.

Bibliometric analysis of publication trends of bullying interventions in preschool age children

Bibliometric analysis of publication trends of bullying interventions in preschool age children

Связь показателей памяти и внимания с использованием настольных и цифровых игр дошкольниками (на примере игры «Dobble»)

&lt;p&gt;The article presents the results of the project &amp;laquo;The Impact of Digital Activity on the Development of Cognitive Functions in Preschool Age&amp;raquo;. The study was conducted from February to May 2023 at the Center for Interdisciplinary Research of Contemporary Childhood at MSUPE, involving 76 children from preparatory groups of kindergartens in Moscow. The following methods were used: the &amp;laquo;Learning 10 Words&amp;raquo; Method (A.R. Luria), D. Weksler's Subtest (the &amp;laquo;Coding Method&amp;raquo;), 3. &amp;nbsp; &amp;nbsp;&amp;laquo;Test of Intertwined Lines&amp;raquo; (A. Rey's Test Modification), and the &amp;laquo;Mark the Signs&amp;raquo; Method (Pieron-Ruser Test). According to the obtained data, the digital version of the game &amp;laquo;Dobble&amp;raquo; has the greatest effect on the development of the studied parameters of memory and attention in preschool children. The obtained empirical data are consistent with the results of similar studies and are of interest to psychologists, educators, and parents in planning and conducting educational and play activities.&lt;/p&gt;

Early relational origins of Theory of Mind: A two-study replication.

Research implies early relational factors - parental appropriate mind-mindedness (MM) and mutually responsive orientation (MRO) - as antecedents of children's Theory of Mind (ToM), yet the longitudinal path is unclear. Furthermore, little is known about the process in father-child relationships. In two studies of community families in a Midwestern state in United States, we tested a path from parental appropriate MM in infancy to parent-child MRO in toddlerhood to children's ToM at preschool age in mother- and father-child relationships, using comparable observational measures at parallel ages. In Children and Parents Study (CAPS) of children born in 2017 and 2018, we collected data at 8 months (N = 200, 96 girls), 38 months, age 3 (N = 175, 86 girls), and 52 months, age 4.5 (N = 177, 86 girls). In Family Study (FS) of children born mostly in 2001, we collected data at 7 months (N = 102, 51 girls), 38 months, age 3 (N = 100, 50 girls), and 52 months, age 4.5 (N = 99, 49 girls). Parental MM (verbal comments aligned with the infant's psychological state) was observed in infancy, MRO (parent and child responsiveness to each other and shared positive affect) at age 3, and ToM (false belief tasks) at age 4.5. The findings supported the proposed indirect effects of parents' MM on children's ToM, mediated by MRO, for fathers and children in both studies, and for mothers and children, in CAPS. In FS, mothers' MM predicted MRO and ToM, but there was no mediation. This investigation, testing a path from MM to MRO to ToM in both mother- and father-child relationships in two longitudinal studies, adds to the literature that has described relations among those constructs but rarely integrated those in one model.

The longitudinal relationship between prenatal maternal cortisol and preschool internalising problems

IntroPrenatal exposure to synthetic glucocorticoids may increase the risk of emotional symptoms in childhood partly by reducing fetal growth. We explored if physiological levels of prenatal maternal cortisol were associated with internalising problems in boys and girls and if this was mediated by birth weight. MethodsMother-child dyads from the prospective Odense Child Cohort (n=1162) were included if maternal serum cortisol (3rd trimester), offspring birth weight, and Child Behaviour Checklist (CBCL) assessments in preschool age were available. Crude and adjusted associations between cortisol and internalising problems were determined in linear mixed models stratified by offspring sex. Covariates included parental psychiatric history, parity, maternal age, education, smoking during pregnancy, and gestational age at birth. In the presence of significant associations, we evaluated the potential mediating role of birth weight. ResultsThe study sample included 601 boys and 561 girls and internalising problems were assessed at mean ages 2.3 (±0.4) and 5 (±0.5) years. In the crude analysis, cortisol was positively associated with internalising problems in boys (p-value 0.017) and in girls (p-value < 0.0001). In the adjusted analyses, there was no statistically significant association between cortisol and offspring internalising problems in boys or girls (all p-values > 0.15). There was no mediation by birth weight. DiscussionMaternal serum cortisol was positively associated with offspring internalising problems in boys and girls, but there was no association following adjustment for potential confounders and no mediation through birth weight. Maternal third-trimester cortisol levels do not predict preschool offspring internalising problems in our study.

Russian Children and Their Relatives: What Can a Free Word Order Language Reveal About the Subject/Object Asymmetry?

ABSTRACT The present study revisits the well-attested phenomenon of Subject/Object Asymmetry in relative clause comprehension by monolingual Russian pre-school children. Additionally, it examines the NP-V and the V-NP word order types when the embedded NP precedes or follows the verb. Both the word orders are grammatical for Russian subject and object relative clauses alike. Object relative clause comprehension difficulty was evidenced across all the age groups. Word order alternation (V-NP vs NP-V) did not significantly affect the accuracy rates. Besides the efficacy of the agent-first strategy, growing morphological knowledge compels children to update their ongoing structural analysis, which results in embedded NP errors. Yet, even at 6 years of age, children do not display word order preferences to go with a particular relative clause type that are found in Russian-speaking adults. Restricted exposure to written texts at pre-school age as well as low validity of word order as a cue to thematic role assignment are discussed as possible reasons for children’s insensitivity to word order manipulation in Russian relative clauses.

ACTUAL PROBLEMS OF PRESCHOOL PEDAGOGY

Preschool pedagogy has a rich history of development: in the 20 th century, a large number of fundamental and applied problems were studied and investigated. Numerous theoretical, experimental and applied researches have made it possible to form the theoretical foundations of preschool pedagogy, to justify the methods and technologies of studying the education and development of children in the preschool age. However, there are still a number of current problems and promising directions for research. The main reasons for their emergence are mainly changes in the political, economic and other spheres of social life. The transition to new socio-economic conditions significantly changes the new view of the pre-school education system, the characteristics of childhood and the child's position in the system of social relations. The development of preschool pedagogy requires the need to further develop new technologies for training and education of children, concepts that are acceptable for modern life conditions and can enrich the experience of preschool education.

Magnitude of emergence agitation, its interventions and associated factors among paediatric surgical patients

BackgroundEmergence agitation is a transient confusional state of a child associated with consciousness from general anaesthesia, commonly occurs in the postoperative setting which delays their recovery and exposes them to traumas. The main objective of the current study was to investigate the magnitude of emergence agitation, its interventions and associated factors among paediatric surgical patients at Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia.MethodsHospital based cross-sectional study with prospective follow-up framework was conducted on a paediatric surgical patients aged 2-14 years who underwent surgery under general anaesthesia between June 1 - October 30 2022. Stratified sampling method followed by simple random sampling technique was employed to reach study participants. Magnitude of emergence agitation and its interventions done at post-anaesthetic care units were recorded. Data analysis was carried out using a descriptive statistics method and the results were summarized using tables and diagrams. Bivariate analysis was done to identify causal relationship and multivariable analysis to assess the confounding effects of factors associated with emergence agitation. A p-value of less than 0.05 was considered statistically significant factor.ResultsA total of 150 participants were included in the current study, where 107 (71.3%) were male and 97 (64.7%) were preschool aged. About 81 (54%) of care givers were female and majority of them have completed primary school. The mean (standard deviation) age of the participants was 6.4 (3.57) years. Around 42.7% of them developed emergence agitation with an average duration of 8.39 ± 4.45 minutes. Factors such as propofol administration at the end of procedure (OR of 0.104 with 95% CI [0.035, 0305]), Ear, nose, throat surgery and oral maxillofacial surgery (OR of 2.341 with 95% CI [1.051, 5.211]) and arrival of patient to recovery awake (OR of 0.456 95% CI [0.209, 0.994]) showed statistically significant association with emergence agitation.ConclusionAlmost half of the study participants experienced emergence agitation which is high magnitude. Ear, nose, throat surgery and oral maxillofacial surgeries were predictive factors of emergence agitation while propofol administration at the end of procedure and arrival of patient to recovery awake significantly decreased risk of emergence agitation. Therefore, anaesthesia personnel should have essential skills and knowledge to effectively care for children perioperatively including to minimize and treat emergence agitation.

Detection of Bordetella spp. in children with pertussis-like illness from 2018 to 2024 in China

To evaluate the role of Bordetella pertussis (B. pertussis), B. parapertussis, B. holmesii, and B. bronchiseptica on pertussis resurgence in China, particularly the sharp rise since the latest winter. Nasopharyngeal swabs collected from children with pertussis-like illness from January 2018 to March 2024 were cultured to detect B. pertussis, B. parapertussis, B. holmesii, and B. bronchiseptica, and tested for all of these except for B. bronchiseptica using a pooled real-time polymerase chain reaction (PCR) kit targeting insertion sequences ptxS1, IS481, IS1001, and hIS1001. Out of the collected 7732 nasopharyngeal swabs, 1531 cases tested positive for B. pertussis (19.8%, 1531/7732), and 10 cases were positive for B. parapertussis (0.1%, 10/7732). B. holmesii and B.bronchiseptica were not detected. The number of specimens and the detection rate of B. pertussis were 1709 and 26.9% (459/1709) in 2018, 1936 and 20.7% (400/1936) in 2019, which sharply declined to 308 and 11.4% (35/308) in 2020, 306 and 4.2% (13/306) in 2021, and then notably increased to 754 and 17.6% (133/754) in 2022, 1842 and 16.0% (295/1842) in 2023, 877 and 22.3% (196/877) in the first quarter of 2024. The proportion of children aged 3 to less than 6 years (preschool age) and 6 to 16 years (school age) in pertussis cases increased significantly during the study period, especially the proportion of school-aged children increased from 2.0% (9/459) in 2018 to 40.8% (80/196) in 2024. B. pertussis was the predominant pathogen among children with pertussis-like illness in China, with sporadic detection of B. parapertussis and no detection of B. holmesii or B.bronchiseptica. The preschool and school-age children are increasingly prevalent in B. pertussis infection cases, which may be associated with the latest rapid escalation of pertussis outbreak.