Objective A Growth and Feeding Clinic (GFC) focused on early intervention around feeding routines in patients with cleft lip and/or palate (CL/P) was implemented. Design This study assessed the effect of preoperative feeding interventions provided by the GFC. Setting Tertiary academic center. Methods This study evaluated patients with CL/P who were cared for by the GFC and a control group of patients with CL/P. Weight-for-age (WFA) Z-score of less than −2.00 was used as a cutoff to classify patients who were underweight during the preoperative period. Main Outcome Measure The number of underweight patients who were able to reach normal weight by the time of their cleft lip repair was used as the primary outcome measure. Results Within both the GFC and control groups, 25% of patients with CL/P were underweight as determined by WFA Z-score. GFC patients who were underweight received more clinic visits ( P < .001) and GFC interventions ( P < .001) compared to GFC patients who were normal weight. At the time of cleft lip surgery, 64.1% of GFC underweight patients were normal weight compared to 31.8% of control group underweight patients ( P = .0187). Conclusion This study showed that multidisciplinary care provided by the GFC was able to target preoperative nutritional interventions to the highest-risk patients, resulting in double the percentage of patients who were of normal weight at the time of their cleft lip repair. These results provide objective proof supporting the assertion that multidisciplinary team care of the infant with cleft leads to measurable improvement in outcomes.