A field experiment on “Integrated Weed Management for preseasonal sugarcane” was conducted for three consecutive years at Central Sugarcane Research Station, Padegaon, Tal Phaltan District Satara, Maharashtra, India during 2015-16 to 2017-18 to find out tank mix optimum combination dose of post emergence herbicide for effective control in sugarcane. Dominant weeds observed in sugarcane crop were Brachiaria eruciformis, Cyperus rotundous, Alternanthera sessils, Parthenium hysterophorus L., Euphorbia geniculata Linn., Cardiosoermum lalicacabum, Ipomoea hederacea and Hylandis latiprosa. The result showed that mean total weed count and weed dry weight reduced with post emergence application of metribuzin @ 0.50 kg a.i.ha-1 + 2, 4-D @ 1.00 kg a.i. ha-1 at 25 DAP fb hoeing at 60 and 90 DAP and found at par with treatment post emergence application of metribuzin @ 1 kg a.i ha-1 + 2, 4-D @ 1 kg a.i. ha-1 at 25 DAP fb hoeing at 60 and 90 DAP. Among the herbicidal treatments, post emergence application of metribuzin @ 0.50 kg a.i ha-1 + 2, 4-D @ 1 kg a.i. ha-1 at 25 DAP fb hoeing at 60 and 90 DAP recorded significantly the highest germination per cent (66.73 %), number of internodes per cane (22) and average cane weight (1.93 kg) over all herbicidal treatments which was at par with pre emergence spray of metribuzin @1 kg a.i. ha-1 and post emergence spray of 2,4-D @1kg a.i. ha-1 at 60 DAP fb hoeing at 90 DAP for number of internodes per cane (21.90) and average cane weight (1.92 kg). Among the herbicidal treatments, maximum weed control efficiency of 60.59 %, 56.38 % and 75.99 % was found in treatment of post emergence application of metribuzin @ 0.50 kg a.i. ha-1+ 2,4-D @ 1.00 kg a.i. ha-1 at 25 DAP fb hoeing at 60 and 90 DAP to sugarcane crop at 30, 60 and 90 days after application, respectively followed by post emergence application of metribuzin @ 1 kg a.i ha-1 + 2, 4-D @ 1 kg a.i. ha-1 at 25 DAP with hoeing at 60 and 90 DAP. Similarly, the significantly highest cane yield (155.21 t ha-1) and CCS yield (21.38 t ha-1) was recorded by same treatment over all herbicidal treatments which was at par with treatment metribuzin @1 kg a.i. ha-1 as pre emergence, 2,4-D @1 kg a.i. ha-1 as post emergence application at 60 DAP fb hoeing at 90 DAP for CCS yield. The maximum net return (Rs. 278454) and benefit cost ratio (3.13) was also reported by same treatment followed by post emergence application of metribuzin @1.00 kg a.i. ha-1 + 2,4-D @ 0.50 kg a.i. ha-1 at 25 DAP fb hoeing at 60 and 90 DAP. The cane quality like commercial cane sugar %, sucrose %, brix (00) and purity % was not affected by hand weeding, mechanical weed control and application of any herbicide.