Preeclampsia Mothers Research Articles

Pengaruh Preeklamsia dan Hipertensi Kronis terhadap Kejadian Bayi Kecil Masa Kehamilan (KMK)

Background: Preeclampsia and chronic hypertension are associated with a large number of cases of small infants during pregnancy (SIP) and perinatal deaths. There are conflicting inconsistencies between research on the effect of preeclampsia and chronic hypertension on KMK. The data showed that preeclampsia had a very significant effect on the occurrence of KMK, but in reality not all infants of preeclampsia mothers gave birth to babies with KMK. This raises the assumption that there are other factors that inhibit the influence of preeclampsia and chronic hypertension on birth weight.Objective: to determine the effect of preeclampsia and chronic hypertension on KMK in Dr. Sardjito Yogyakarta.Method: Retrospective cohort. Data of maternity patients with preeclampsia, maternity patients with chronic hypertension, and weight data of babies born at RSUP Dr. Sardjito were recorded. Also noted parity, maternal age, employment and education. Data were taken from medical records and classified into normotension, preeclampsia, and chronic hypertension using consecutive sampling methods.Result and Discussion: There were 81 samples for each normotension group, preeclampsia, and chronic hypertension. Preeclampsia is significantly at risk of experiencing SIP 7,43 times (95% IK 3,13-17,66). Chronic hypertension is significantly at risk of experiencing 5,15 times SIP% IK 2,15-12,36). Multigravida subjects were at risk of experiencing SIP 1,92 times (IK 95% 1,04-3,55) There was no significant difference in the proportion of SIP in subjects based on age, occupation, and education.Conclusion: Preeclampsia, chronic hypertension, and multigravida parity significantly provide a higher risk of the incidence of SIP. If the three factors work together, they will reinforce the effect on increasing the risk of SIP.Keywords: Small gestational period; preeclampsia; chronic hypertension

393. InterPregGen: The discovery and validation of genetic variants associated with pre-eclampsia in mothers and babies

30 years of molecular genetic studies of common disorders have demonstrated the need for large, well-powered studies to detect genetic variants with individually small effects on disease susceptibility; pre-eclampsia is no exception. InterPregGen is a collaboration between research groups from Europe and Central Asia seeking to identify DNA sequence variants predisposing to pre-eclampsia. The primary approach is meta-analysis of genome-wide association screening (GWAS) data from over 9000 affected mothers, 6500 offspring, and 370,000 control subjects. Variants with evidence of association with pre-eclampsia are followed-up by targeted genotyping in independent sample collections. In offspring affected by pre-eclampsia there is a highly significant association with a common variant located close to the FLT1 gene, which encodes Fms-like tyrosine kinase 1 and its soluble isoform sFlt-1 (P = 5.38 × 10 - 11 ) . The strongest association was in pregnancies with onset of pre-eclampsia after 34 weeks gestation. Investigation of the maternal genome in pre-eclampsia has highlighted associations with multiple DNA variants which also have confirmed associations with essential hypertension in non-pregnant individuals. In a further 2800 women with non-proteinuric gestational hypertension there is a similar profile of susceptibility variants shared with essential hypertension and pre-eclampsia. Typical of many common complex disorders, there is no single ‘pre-eclampsia gene’. Current parental or fetal genotype data do not enable prediction of preeclampsia in individual pregnancies. However, the results highlight specific biological pathways responsible for pre-eclampsia’s aetiology. Larger studies are essential to identify additional variants and other pathways affecting pre-eclampsia. The genetic findings justify targeted investigation of FLT1 regulation in the placenta, and indicate that raised sFlt-1 has a causal role in pre-eclampsia, and is not just a consequence of the disease. Maternal genotyping results confirm a pathophysiological overlap between essential hypertension, gestational hypertension and pre-eclampsia, and emphasise the imperative for long-term cardiovascular monitoring of women with a history of hypertension in pregnancy.

349. Association between body mass index and preeclamspia

Lipotoxicity is a consequence from low grade inflammation caused by obesity. Women presenting body mass index (BMI) above 35 kg/m[b] have four times higher risk of preeclampsia development (Bianco, 1998). To characterize the association of BMI and maternal and perinatal variables between puerperas with and withoutpreeclampsia. transversal study, Hospital Guilherme Álvaro-Santos/Brazil, (January/2015-March/2016). Antropometric data was collected from 160 women (immediate postpartum), 75 patients without preeclampsia (control group) and 85 with preeclampsia (case group). Variables: blood pressure (hospital admission), gestational age at childbirth and immediate perinatal outcome. Average mother age and BMI were 25 years and 26 kg/m[b] for the control group, in the group case: 29 years and 35 kg/m[b]. Patients with pre-eclampsia showed higher blood pressure: medium level of 136 mmHg (sistolyc) and 85 mmHg (diastolic). 84% of the deliveries in the case group were cesarean sections and the majority of these women had gestation resolution above 37 weeks. Newborns out of pre-eclampsia mothers weighed among 2685 g and five-minute Apgar score was 8,7. Those neonates presented higher admission rates in a ICU (36.5%) and 12% were small for gestational age. Cesarean in 84% of births in the case group and 40% case of births occurred in prematurity. Newborns of mothers with preeclampsia weighed on average 2685 g, average 5’ Apgar score of 8,7, higher rates of admission to ICU (36.5%) and 12% were small for gestational age. Was observed in women with preeclampsia higher average BMI and blood pressure values and their newborns showed smaller weight and 5’ Apgar score, need frequent admission to ICU and prematurity. Reproductive counseling appears to be relevant to the obese women to warn about potential complications, it’s important to adopt strategies for assistance to this population to qualify the attendance, particularly in actions preventive and possible reduction in the rate of cesarean section that could magnify risks.

Hypertensive Disorders during Pregnancy and Risk of Bronchopulmonary Dysplasia in Very Preterm Infants.

It is not yet fully known whether hypertensive disorders (HTD) during pregnancy impose an increased risk of development of bronchopulmonary dysplasia (BPD) in preterm newborn infants. To test the hypothesis that preeclampsia and other HTD are associated with the development of BPD in preterm infants. Data on mothers and preterm infants with gestational age 24 to 30 weeks were prospectively analyzed in 11 Portuguese level III centers. Statistical analysis was performed using IBM SPSS statistics 23. A total of 494 preterm infants from 410 mothers were enrolled, and 119 (28%) of the 425 babies, still alive at 36 weeks, developed BPD. The association between chronic arterial hypertension, chronic arterial hypertension with superimposed preeclampsia, and gestational hypertension in mothers and BPD in preterm infants was not significant (p = 0.115; p = 0.248; p = 0.060, respectively). The association between preeclampsia-eclampsia and BPD was significant (p = 0.007). The multivariate analysis revealed an association between preeclampsia-eclampsia and BPD (odds ratio [OR] = 4.6; 95% confidence interval [CI] 1.529-13.819; p = 0.007) and a protective effect for BPD when preeclampsia occurred superimposed on chronic arterial hypertension in mothers (OR = 0.077; 95%CI 0.009-0.632; p = 0.017). The results of this study support the association of preeclampsia in mothers with BPD in preterm babies and suggest that chronic hypertension may be protective for preterm babies.

Characteristic of Referral Patients With Severe Preeclampsia In Surabaya

Introductions: Pre-eclampsia is a hypertensive disorder of a pregnancy that remains major maternal mortality in developing country. Severe pre-eclampsia needed an advanced medical treatment since it could cause life treathening condition for both mother and fetus. The purpose of this research was to understand and got the picture of the age, parity, complication, delivery method, referral pathway, age of pregnancy, birth weight, and Apgar score of baby from pre-eclamptic mother in dr. Soetomo General Hospital during 2011.Methods: This research is a retrospective-descriptive research which observed the age, parity, complication, delivery method, referral pathway, age of pregnancy, birth weight, and Apgar score of baby from pre-eclampsia mother This research used medical record then the data was recorded and analyzed descriptively.Result: The number of patients who met the inclusion criteria were 239 patients. Patient’s age were distributed unimodally with a peak at productive age. Most of patients had previous history of pregnancy. Pulmonary edema was the most common cause of maternal complication and intra uterine fetal death was the most common cause of fetal complication. Most delivery were performed in Sectio Caesaria method. Almost all cases was direct refferal cases from other medical services. Then most of cases was reaching aterm periode. Most of babies were born with body weight ≥ 2500 gram. And based on Apgar score the babies were well adapted.Conclusions: Most of the patients with severe preeclampsia referrals were referred from a health care setting, only a small percentage of women were referred to relay. Most of severe preeclampsia occured in women with their gestational age has reached 37 weeks.

Preeclampsia predicts higher incidence of bronchopulmonary dysplasia.

It is not known whether very preterm infants born to preeclamptic women have worse outcomes than those delivered preterm for other causes. We assessed the association between preeclampsia (PE) and the neonatal morbidity and mortality of very preterm infants. Over 2015 and 2016, 11 collaborating Portuguese level III NICUs prospectively enrolled a cohort of mothers with or without PE who delivered liveborn premature infants between 24 and 30 completed weeks of gestation. Data on neonatal morbidities were collected and their association to PE was assessed. The final cohort consisted of 410 mothers who delivered 494 preterm infants. Infants from PE mothers weighed less than those of non-PE mothers (819 ± 207 g vs. 989 ± 256 g, p < 0.0001). Incidences of respiratory distress syndrome, patent ductus arteriosus, early and nosocomial sepsis, necrotizing enterocolitis, pneumonia, meningitis, retinopathy of prematurity, intraventricular hemorrhage, periventricular infarction, periventricular leukomalacia, and mortality did not differ significantly between infants of PE or non-PE mothers. Incidence of bronchopulmonary dysplasia (BPD-defined as oxygen dependency at 36 weeks) was higher in PE infants compared with non-PE infants by both univariate and multivariate logistic regression (p = 0.007). We conclude that, when controlling for gestational age, maternal PE results in higher incidence of only BPD among preterm Portuguese infants.

Increased incidence of preeclampsia in mothers of advanced age conceiving by oocyte donation.

The aim of this study was to evaluate the risk of preeclampsia in women of advanced age who conceived through donated oocytes as compared with natural conceptions. A historical prospective study of singleton live births of parturients≥45years of age at four university hospitals was conducted. For the purpose of the study, the population was divided by the mode of conception into two groups: oocyte donation and natural conception. The main outcome variable in this study was preeclampsia. Secondary outcomes included pregnancy-induced hypertension and Small for Gestational Age. Two hundred and seventy pregnancies were achieved naturally and 135 women conceived by oocyte donation. Mean age at delivery for the natural conception and oocyte donation groups was 45.7 and 47.8, respectively. Preeclampsia complicated 3 out of 270 (1.1%) natural conception pregnancies and 17 out of 135 (12.6%) oocyte donation conceptions. After adjusting for confounders, oocyte donation pregnancies were found to be associated with a 12-fold increased risk for preeclampsia (P=0.001). Among oocyte donation pregnancies, the risk of preeclampsia was not affected by parity or age. A substantially increased risk for preeclampsia was found in oocyte donation pregnancies, suggesting that the foreign oocyte may play a specific biologic role in the development of preeclampsia after the age of 45.

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia.

Preeclampsia is a vascular pregnancy disorder that often involves impaired placental development. HO-1 (heme oxygenase 1, encoded by HMOX1) is a stress response enzyme crucial for endothelial and placental function. Long version of the guanine-thymine (GTn) microsatellite in the HMOX1 promoter decreases HO-1 expression, and the long maternal repeat is associated with late-onset preeclampsia. Our aim was to study whether the length of fetal repeat is associated with mother's preeclampsia, whether the length of fetal and maternal repeats affect HO-1 levels in placenta and maternal serum, and whether HO-1 levels are altered in preeclampsia. We genotyped the repeat in the cord blood of 609 preeclamptic and 745 nonpreeclamptic neonates. HO-1 levels were measured in 36 placental samples, and in the first (222 cases/243 controls) and third (176 cases/53 controls) pregnancy trimester serum samples using enzyme-linked immunosorbent assay. The long fetal GTn repeat was associated with preeclampsia and its severe and early-onset subtypes. Interaction analysis suggested the maternal and fetal effects to be independent. Placental or serum HO-1 levels were not altered in preeclamptics, possibly reflecting heterogeneity of preeclampsia. Carriers of the long fetal and maternal repeats had lower placental and serum HO-1 levels, respectively, providing functional evidence for the association. We conclude that the long fetal GTn repeat may increase mother's risk for especially severe and early-onset preeclampsia. The fetal and maternal risk alleles likely predispose to different disease subtypes.

OP 12 Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancy

Introduction Obesity is a recognised risk factor for preeclampsia and adipose tissue inflammation may contribute to its pathology. Objectives To compare adipose tissue macrophage infiltration and release of pro-inflammatory adipokines in pre-eclampsia and healthy pregnancy. Patients and methods Subcutaneous and visceral adipose tissue biopsies were collected from healthy ( n = 13) and preeclampsia ( n = 13) mothers. Basal and lipopolysaccharide-stimulated adipocyte TNF α , IL-6, CCL-2, CRP and sflt-1 release was measured. Adipose tissue cell densities of activated (cfms+) and total (CD68+) macrophages and gene expression of adipokines were determined. Results In pre-eclampsia only, visceral adipose tissue TNF α release was increased after lipopolysaccharide stimulation (mean [SD] 57 [76] vs 81 [97] pg/mL/ug DNA, p = 0.030). Basal TNF α release was negatively correlated with insulin sensitivity of visceral adipocytes ( r = −0.61, p = 0.030) in pre-eclampsia. Visceral adipocyte IL-6 release was increased after lipopolysaccharide stimulation in pre-eclampsia only (566 [696] vs 852 [914] pg/mL/μgDNA, p = 0.019). Visceral adipocyte CCL-2 basal (67 [61] vs 187 [219] pg/mL/ugDNA, p = 0.049) and stimulated (46 [46] vs 224 [271] pg/mL/μgDNA, p = 0.003) release was higher than in subcutaneous adipocytes in pre-eclampsia only. In pre-eclampsia, median TNF mRNA expression in visceral adipose tissue was higher than controls (median [interquartile range] 1.94 [1.13–4.14] vs 0.8 [0.00–1.27] TNF / PPIA ratio, p = 0.006). In visceral adipose tissue, CSF1R (a marker of activated macrophages) mRNA expression (24.8 [11.0] vs 51.0 [29.9] CSF1R/PPIA ratio, p = 0.011) and activated (cfms+) macrophage count (6.7 [2.6] vs 15.2 [8.8] % cfms+/adipocyte, p = 0.031) were higher in pre-eclampsia than in controls. Conclusion This study demonstrates dysregulation of inflammatory pathways predominantly in visceral adipose tissue in pre-eclampsia. Inflammation of visceral adipose tissue may mediate many of the adverse metabolic effects associated with pre-eclampsia.

Comparison of Abdominal Aorta Intima-Media Thickness, Serum Level of Leptin, and Lipid Profile between Maternal Preeclampsia and Neonatal Outcomes

Background Pre-eclampsia is one of the main causes of morbidity and mortality among pregnant women. This study was done with the objective of measuring abdominal aorta intima-media thickness, serum level of leptin, and lipid profile in neonates of pre-eclampsia mothers and comparing them with neonates of mothers without pre-eclampsia (control group). Materials and Methods Ninety neonates of pregnant mothers, who delivered their babies at Imam Reza Hospital of Kermanshah University of Medical Sciences, were included. They were divided into mild pre-eclampsia (15 neonates), severe pre-eclampsia (15 neonates), and control group (60 neonates). Their blood samples were delivered to the laboratory to assay leptin and lipid profile. Also, echocardiography was done to determine the thickness of intima-media of the abdominal aorta. The data were analyzed by SPSS software using Pearson correlation test and analysis of variance (for variables with normal distribution) and Spearman coefficient test and Kruskal-Wallis tests for variables with non-normal distribution. Results The minimum and maximum ages of mothers in all groups were 20 and 35 years, respectively. There was no significant difference between the mild pre-eclampsia, severe pre-eclampsia, and those without pre-eclampsia regarding serum leptin level and lipid profile (P> 0.05). However, there was significant difference between the groups regarding intima-media thickness (P< 0.05). Mean (± standard deviation) intima-media thickness was the highest in severe pre-eclampsia group (0.629±0.034) and the lowest in control group (0.472±0.058). Conclusion Neonates of mothers with pre-eclampsia had higher measurements of abdominal aorta intima-media thickness compared to control group.

Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancys.

Obesity increases pre-eclampsia (PE) risk. Adipose tissue inflammation may contribute to the clinical syndrome of PE. We compared adipose tissue macrophage infiltration and release of pro-inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from healthy (n=13) and PE (n=13) mothers. Basal and lipopolysaccharide (LPS) stimulated adipocyte TNFα, IL-6, CCL-2, and CRP release was measured. Adipose tissue cell densities of activated (cfms+) and total (CD68+) macrophages were determined. In PE only, visceral adipose tissue TNFα release was increased after LPS stimulation (57 [76] versus 81 [97] pg/ml/µg DNA, P=0.030). Basal TNFα release was negatively correlated insulin sensitivity of visceral adipocytes (r = −0.61, P=0.030) in PE. Visceral adipocyte IL-6 release was increased after LPS stimulation in PE only (566 [696] versus 852 [914] pg/ml/µg DNA, P=0.019). Visceral adipocyte CCL-2 basal (67 [61] versus 187 [219] pg/ml/µgDNA, P=0.049) and stimulated (46 [46] versus 224 [271] pg/ml/µg DNA, P=0.003) release was greater than in subcutaneous adipocytes in PE only. In PE, median TNF mRNA expression in visceral adipose tissue was higher than controls (1.94 [1.13–4.14] versus 0.8 [0.00–1.27] TNF/PPIA ratio, P=0.006). In visceral adipose tissue, CSF1R (a marker of activated macrophages) mRNA expression (24.8[11.0] versus 51.0[29.9] CSF1R/PPIA ratio, P=0.011) and activated (cfms+) macrophage count (6.7[2.6] versus 15.2[8.8] % cfms+/adipocyte, P=0.031) were higher in PE than in controls. In conclusion, our study demonstrates dysregulation of inflammatory pathways predominantly in visceral adipose tissue in PE. Inflammation of visceral adipose tissue may mediate many of the adverse metabolic effects associated with PE.

Immune cell subsets, cytokine and cortisol levels during the first week of life in neonates born to pre-eclamptic mothers.

To address the hypothesis that pre-eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre-term newborns of PE mothers. Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre-term infants affected by PE and 14 non-PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry. The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates. Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.

Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity

Objective: To evaluate neonatal outcomes of pregnancies complicated by early-onset preeclampsia (PE) and compare these outcomes to those of gestational age matched neonates born to mothers whose pregnancy was not complicated by early-onset PE.Methods: We analyzed the outcome in 97 neonates born to mothers with early-onset PE (24–32 weeks amenorrhea at diagnosis) and compared it to that of 680 gestational age-matched neonates born between 25–36 weeks due to other etiologies and admitted to the Neonatal Intensive Care Unit (NICU) of a tertiary referral hospital in the Netherlands. We used Chi-square test, Wilcoxon test, and logistic regression analyses.Results: Neonates born to PE mothers had a higher perinatal mortality (13% vs. 7%, p = 0.03) and infant mortality (16% vs. 9%, p= 0.03), a 20% lower birth weight (1150 vs. 1430 g, p<0.001), were more often SGA (22% vs. 9%, p < 0.001) and had more neonatal complications as compared to neonates born to mothers without PE.Conclusions: Overall adverse perinatal outcome is significantly worse in neonates born to mothers with early-onset PE. The effect of early-onset PE on perinatal mortality seems partially due to SGA. Whether these differences are due to uteroplacental factors or intrinsic neonatal factors remains to be elucidated.

Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure.

Preeclampsia (PE) is pregnancy-induced hypertension with proteinuria that typically develops after 20 wk of gestation. Antihypertensives currently used for PE reduce blood pressure of PE mothers but do not prevent preterm delivery and do not alleviate fetal growth restriction (FGR) associated with PE. We have recently shown that the activation of the endothelin (ET) system exacerbates PE. However, ET receptor antagonists are teratogenic and not suitable for pregnant women. The vitamin B3 nicotinamide (Nam) inhibits vasoconstriction by ET and is generally considered safe and harmless to babies. Nam also alleviates oxidative stress, which exacerbates PE and FGR. The aim of the present study was to evaluate therapeutic effects of Nam on the PE-like phenotype using a reduced uterine perfusion pressure (RUPP) model in mice that we have recently developed. We bilaterally ligated uterine vessels of pregnant mice and administered Nam or water daily by gavage. Nam improved maternal hypertension, proteinuria, and glomerular endotheliosis in RUPP mice. Moreover, Nam prolonged pregnancies and improved survival and growth of the embryos in RUPP PE mice. In conclusion, Nam alleviates the PE-like phenotype and FGR in the murine RUPP model. Nam could help treat maternal hypertension and FGR in human PE.

Prospective assessment of neurodevelopment in children following a pregnancy complicated by severe pre-eclampsia

ObjectiveTo prospectively examine whether children of women with a pregnancy affected by severe pre-eclampsia (PE), compared to children of women without a PE-affected pregnancy, have differences in neurodevelopmental performance up...

Morphological changes of newborns coronary vessels in preeclampsia in mothers

Morphological changes of newborns coronary vessels in preeclampsia in mothers

“A Study To Assess the Effectiveness of Self Instructional Module on Knowledge Regarding The Selected Care of Pre-Eclampsia Patient Among Nurses in Selected Hospitals of Vidarbha Region.”

title: Effectiveness of Self Instructional Module on knowledge regarding the selected care of pre- eclampsia patient among nurses. Background: Pre-eclampsia mothers are more dependent on nurses to meet their basic needs than other Antenatal mothers. It is syndrome of hypertension and proteinuria, is a major cause of maternal and perinatal morbidity and mortality. To minimize mortality and morbidity, it is important to identify cases of pre-eclampsia, to provide efficent and effecticve nursing care to them. Aim: To assess the effectiveness of self instructional module on knowledge regarding preeclampsia among nurses. Methods: One group pre testpost test design was used for the study. 60(Nurses working in obstetric ward and OP, usingnon probability convenient samplingsampling technique were selected for the study. Knowledge of nurses was assessed by using structured questionnaire before distributing self-learning module (SIM) and after 7 days of distributing SIM endpoint data was collected. Findings: The SIM was useful in improving the knowledge of nursesInpretest 12% samples has average knowledge and 80% samples had good knowledge where as in post test 100% samples had excellent knowledge. Conclusion and implications for clinical nursing: The self instructional module significantly improved the

Learning about human nature and analytic technique from mothers and babies

In this paper, observational material is presented from a mother–infant pair observed from pregnancy up to the baby's third birthday. Two observers accompanied the mismatched steps of Tânia and Julie, who had to be born ahead of her time because of her mother's pre-eclampsia. This provoked a huge challenge to their sense of continuity and of connection, a basic pre-condition for human development. This observation underlines the importance of the mother's flexibility in adapting to changes and interruptions. The observation provides a fascinating glimpse into the mother–baby couple's creative recovery within a tailor-made protective, caring space of mutual growth. The authors see this longitudinal study, which extends the standard Bick method to include pregnancy and delivery, as a great opportunity to learn more about human nature. It also enables further development of knowledge and understanding of the basic principles of therapeutic and preventative work in the early years, with the principal goal of facilitating the natural pull towards integration and growth, in the mother–infant couple who illuminate its care-cure aspect.

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Serum levels of suppressor of cytokine signaling 3, tumor necrosis factor-alpha and interleukin-10 in preeclampsia mothers and their clinical values

To explore the serum levels of suppressor of cytokine signaling 3 (SOCS3), tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) in preeclampsia mothers and determine their clinical values. A total of 40 preeclampsia mothers at International Peace Maternity and Child Health Hospital of China Welfare Institute Affiliated to Shanghai Jiaotong University from March 2011 to August 2013 were enrolled into observation group. Another 40 cases of mothers without pregnancy complications were selected as control group. Then the serum contents of SOCS3, TNF-α and IL-10 were detected and their correlations analyzed. (1) The mRNA levels of SOCS3 of observation and control groups were 38 ± 6and 100 ± 16while the mRNA levels of TNF-α 226 ± 40 and 100 ± 19 respectively; (2)the proteins levels of SOCS3 of observation group were lower than those of control group (P < 0.05) while the proteins levels of TNF-α of observation group were higher than those of control group (P < 0.05); (3)the mRNA and protein contents of SOCS3 were negatively correlated with mRNA and protein contents of TNF-α and positively correlated with IL-10. The serum content of SOCS3 decreases significantly in preeclampsia so that there is a down-regulation of Th1 type cytokine TNF-α and an up-regulation of Th2 type cytokine IL-10. And it may play an important role in the occurrence of disease.