AbstractDMEK is a surgical technique that is now known by many surgeons and is gradually replacing other surgical techniques in the management of corneal endothelial pathologies. There are currently several different preparation techniques, the most famous and most widely used being the initial technique described by Guerrit Melles. During this procedure, the Descemet membrane is detached using one or two forceps from the periphery. The isolated graft rolls spontaneously with the endothelium outside. It is then aspirated into a glass cartridge before being injected into the anterior chamber. Another preparation technique we have described is to detach the Descemet membrane by hydrodissection after inverting the corneal curvature. It is then possible to roll the graft with the endothelium inside, and mark it easily before inserting it into an injection cartridge. The main advantages are the easier unfolding of the graft and the assurance of positioning it in the right position. A third technique consists in detaching the Descemet membrane by performing a Big Bubble technique but it is not always possible to isolate a graft larger than 7 mm. Whatever the technique, the most important thing for each surgeon is to train regularly in order to choose the procedure that best suits him. There does not seem to be any difference in terms of endothelial cell loss depending on each technique. It should also be kept in mind that the performance of a DMEK is accompanied by a greater number of post‐operative graft detachment and that other endothelial graft techniques should be proposed in case of specific surgical conditions. In addition, the precut techniques proposed by corneal banks are now making the surgical procedure even easier and faster.