Climate variables mainly greenhouse gas (GHG) emissions, temperature, precipitation, and rainfall are affecting crop production across the world. Nepal as a vulnerable country in terms of climate change, has raised the attention of researchers and policymakers in recent years. In this scenario, this study has attempted to find the impact of GHG emissions, temperature, and precipitation on rice production in Nepal. The study is based on time serried data from 1990 to 2019. The findings show that GHG emission has a significant positive impact on rice production. However, the annual average mean temperature has a significant negative impact on rice production. Besides having a negative coefficient, precipitation did not affect rice production significantly. The study recommends concrete climate change adaptation practices in the major rice production areas of Nepal, mainly in the Terai and Hilly belts.