Considering theory-focused and relatively dull content of Theory of Missile Guidance and Control, and the low learning motivation and weak practical skills of the students, this paper describes the practice and experience of blended teaching reform in the course. A comprehensive analysis was done on real demands of students’ ability, the nature of the course and characteristics of content. The teaching idea of building a solid foundation, emphasizing on the operation of the of equipment, actual combat, and the development of equipment was applied. In order to improve the students’ abilities and their understanding of the subjects, a new blended teaching mode for the theoretical course of equipment was explored, so as to form an evolving cycle of “theoretical study, hands-on practical, and forming new abilities,” spark the students’ interest in learning, and cultivate new thoughts in autonomous learning and innovative practice. This teaching mode has been practiced for a few years and is shown to be effective in improving the ability of students and the quality of training for personnel of military technology. Therefore, it can be used as a reference for curriculum reform of courses involving equipment.