The purpose of this study is to identify factors influencing nursing practice for infections control in intensive care units (ICUs). Participants were 201 registered nurses who worked in ICUs of general hospitals. Data were collected using a self-administered questionnaire from September 10 to October 6, 2023. And were analyzed using the t-test, One-way ANOVA, Pearson correlation coefficients and multiple regression analysis with the SPSS 28.0 program. Through multiple regression analysis, the factors influencing nursing Practice in ICUs were awareness of infection control (β=.76, p<.001), working unit (NCU) (β=.10, p=.043). The explanation power of these variables was 65.0% (F=46.78, p<.001). Education to enhance awareness on infection control should be established. There is a need to organize and provide specialized education and training programs for each unit.