For those of a certain generation there was a time before routine HbA1c measurement, when the adequacy of diabetes control was assessed simply from serial urine tests supplemented by the occasional random blood glucose estimation. Seemingly sufficient at the time, we now know this means of monitoring was clearly inadequate, and the consequence of such inevitable poor control was associated with a prevalence of serious long-term diabetic complications substantially higher than those seen today. Along with blood glucose self-monitoring, the introduction of HbA1c measurement in the early 1980s heralded an exceptional milestone in diabetes care, coincident with developing awareness that good diabetes control was important if risk of complications was to be minimised. The principle of having an extended time-linked indicator of diabetes control was an entirely new concept in clinical care and its implications were immediately apparent to both patient and doctor alike (no specialist nurses on the scene at this stage!). Initially restricted to specialist hospital-based diabetic clinics, where in fact the majority of people with diabetes were then seen, HbA1c testing gradually became an established part of good clinical practice in diabetes care and an essential component of the annual review process. Indeed, its importance is recognised by priority inclusion within current ‘Quality Framework’ targets. All now involved in delivering diabetes care will be fully familiar with the fundamental knowledge gained from HbA1c measurement as an indicator of overall glycaemic control and that, derived from studies such as DCCT and UKPDS, the results can be extrapolated to provide an evidenced-based signal of long-term risk for the development of diabetic complications. Health care professionals now depend on the ready availability of quality-assured, reliable HbA1c measurement and the latest result will always be a main focus of discussion in a clinical consultation. Much will pivot on that outcome. However, its interpretation has not always been that straightforward. The similarity of unit expression between blood glucose concentration and HbA1c as a percentage of total haemoglobin often gives rise to the impression that both are one and the same. Yet, they are clearly not so and with the HbA1c% tracking significantly below the average glucose, a false interpretation of control may be made. In addition, despite laboratory efforts to reference to the DCCT specific standard, a need for a better global standardisation has been identified. For these and other reasons from 1 June 2009 the unit of measurement of HbA1c will change to mmol/mol and the figures will look very different. For example, present HbA1c levels of 6.5% and 7.5% will be reported as 48 mmol/mol and 59 mmol/mol, respectively (Table 1). For two years the old units will still be provided in parallel. The principle of measurement remains the same and some limitations as previously in respect of certain confounding haematological disorders remain. Yet it will require a focused educational exercise to ensure that the new reporting of HbA1c is understood and implemented safely into routine clinical diabetes care. With this purpose in mind two information sheets, one for clinical health care professionals and one for people with diabetes, have been produced from the Association for Clinical Biochemistry, NHS Diabetes and Diabetes UK. Copies can be downloaded from the latter's website: www.diabetes.nhs.uk. The changeover is imminent but it will be an interesting transitional time.