Practical Use Research Articles

Neuropathologic Validation and Diagnostic Accuracy of Presynaptic Dopaminergic Imaging in the Diagnosis of Parkinsonism.

Degeneration of the presynaptic nigrostriatal dopaminergic system is one of the main biological features of Parkinson disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), which can be measured using single-photon emission CT imaging for diagnostic purposes. Despite its widespread use in clinical practice and research, the diagnostic properties of presynaptic nigrostriatal dopaminergic (DAT) imaging in parkinsonism have never been evaluated against the diagnostic gold standard of neuropathology. The aim of this study was to evaluate the diagnostic parameters of DAT imaging compared with pathologic diagnosis in patients with parkinsonism. Retrospective cohort study of patients with DAT imaging for the investigation of a clinically uncertain parkinsonism with brain donation between 2010 and 2021 to the Queen Square Brain Bank (London). Patients with DAT imaging for investigation of pure ataxia or dementia syndromes without parkinsonism were excluded. Those with a pathologic diagnosis of PD, MSA, PSP, or CBD were considered presynaptic dopaminergic parkinsonism, and other pathologies were considered postsynaptic for the analysis. DAT imaging was performed in routine clinical practice and visually classified by hospital nuclear medicine specialists as normal or abnormal. The results were correlated with neuropathologic diagnosis to calculate diagnostic accuracy parameters for the diagnosis of presynaptic dopaminergic parkinsonism. All of 47 patients with PD, 41 of 42 with MSA, 68 of 73 with PSP, and 6 of 10 with CBD (sensitivity 100%, 97.6%, 93.2%, and 60%, respectively) had abnormal presynaptic dopaminergic imaging. Eight of 17 patients with presumed postsynaptic parkinsonism had abnormal scans (specificity 52.9%). DAT imaging has very high sensitivity and negative predictive value for the diagnosis of presynaptic dopaminergic parkinsonism, particularly for PD. However, patients with CBD, and to a lesser extent PSP (of various phenotypes) and MSA (with predominant ataxia), can show normal DAT imaging. A range of other neurodegenerative disorders may have abnormal DAT scans with low specificity in the differential diagnosis of parkinsonism. DAT imaging is a useful diagnostic tool in the differential diagnosis of parkinsonism, although clinicians should be aware of its diagnostic properties and limitations. This study provides Class II evidence that DAT imaging does not accurately distinguish between presynaptic dopaminergic parkinsonism and non-presynaptic dopaminergic parkinsonism.

Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds

Chronic skin wounds are a serious complication of diabetes with a high incidence rate, which can lead to disability or even death. Previous studies have shown that mesenchymal stem cells derived extracellular vesicles (EVs) have beneficial effects on wound healing. However, the human foreskin mesenchymal stem cell (FSMSCs)-derived extracellular vesicle (FM-EV) has not yet been isolated and characterized. Furthermore, the limited supply and short lifespan of EVs also hinder their practical use. In this study, we developed an injectable dual-physical cross-linking hydrogel (PSiW) with self-healing, adhesive, and antibacterial properties, using polyvinylpyrrolidone and silicotungstic acid to load FM-EV. The EVs were evenly distributed in the hydrogel and continuously released. In vivo and vitro tests demonstrated that the synergistic effect of EVs and hydrogel could significantly promote the repair of diabetic wounds by regulating macrophage polarization, promoting angiogenesis, and improving the microenvironment. Overall, the obtained EVs-loaded hydrogels developed in this work exhibited promising applicability for the repair of chronic skin wounds in diabetes patients.

An environmentally friendly and scalable manufacturing route to the high performance composite polymer electrolytes for lithium-metal batteries

Environmentally friendly manufacturing of flexible all-solid-state electrolytes in large-scale and low cost is important for market entering of lithium metal batteries. Herein, a simple and practical solvent-free route to the high performance composite polymer electrolyte is proposed by infiltrating the hot-molten polyether polymer (F127)/Li-salt (LiTFSI) slurry into a thin cellulose fibrous membrane. The good compatibility between the slurry and cellulose membrane allows the formation of a highly dense F127/LiTFSI/cellulose composite electrolyte with a thin thickness of 28 μm. The solvent-free feature without side-reaction as well as the good mechanical stability of such electrolyte makes great significance to ensure the safety and stability of the batteries. Therefore, its Li symmetric cell can stably operate with an ultralong lifespan of more than 3600 h without dendritic growth of metal lithium, and the LiFePO4//Li cell can also deliver an excellent cycling stability with an initial capacity of 130.1 mAh g−1 and a capacity retention of 84.11 % after more than 260 cycles at 0.5C and 60 °C. Additionally, the performance of high-loading cathode full cell and the flexible pouch cell further confirm its excellent stability and safety for practical use.

Optimizing loss functions for improved energy demand prediction in smart power grids

In this paper, our aim is to improve the accuracy and effectiveness of energy demand forecasting, particularly within modern electricity transmission systems and smart grid technology. To achieve this, we developed a hybrid approach that combines machine learning, representation learning, and other deep learning techniques. This approach is based on extracting essential features, including time-based attributes, identifiable trends, and optimal lags. The outcome of our investigation is the observation that triplet losses demonstrate remarkable accuracy, particularly when employed with a larger margin size and for longer prediction lengths. This finding signifies a substantial improvement in the precision and reliability of energy demand forecasting within modern electricity transmission systems. Our research not only improves predictive modeling in the power grid but also demonstrates the practical use of advanced analytics in addressing renewable energy integration challenges, refining energy demand forecasting for efficient management, system operation, and market analysis.

Is the Calgary-Cambridge Model of consultation a suitable communication tool for students and newly qualified paramedics? A qualitative study

Introduction: The Calgary-Cambridge Model (C-CM), developed by Kurtz and Silverman in 1996, is a communication tool developed for doctors. Since its publication, it has been adopted by various healthcare professionals; however, no previous research has been identified that evaluates its use in paramedic practice. This study aims to explore the experience of students and newly qualified paramedics (NQPs) applying the C-CM in practice, and establish their experiences and perceptions of its suitability as a communication tool in the pre-hospital environment.Methods: This MSc research project, conducted in April‐May 2021, applied qualitative methods with thematic analysis to written reflections and semi-structured interview transcripts discussing the implementation of C-CM in paramedic practice. A convenience-quota sample of 11 participants, consisting of third-year paramedic students and recent NQPs, were recruited. This research is reported using Consolidated Criteria for Reporting Qualitative Research (COREQ) reporting guidelines.Results: Eleven participants were recruited in total; nine consented to reflective writing analysis and interviews, two consented to writing analysis only. Analysis of the writing samples allowed for a deductive approach to the interview plan. Participants consisted of seven males and four females. All eleven participants (ten British and one Indian) spoke English as a first language. Ages ranged from 18 to 59 years. Career status was 46.2% third-year students and 53.8% NQPs. Four major themes were identified: barriers to implementation of the C-CM in practice; impact of C-CM on paramedic practice; C-CM as a teaching and learning tool in paramedic practice; and adaptation of C-CM for paramedic practice.Conclusions: Participants suggested that implementation of C-CM leads to improved structure and shared decision-making; however, adaptions to make it more paramedic-focused would be welcomed. The diversity of patients and their preferences can make its implementation challenging, and the negative feedback received from experienced ambulance staff was a significant concern to participants.

Development and validation of a novel Barrett's oesophagus patient reported outcome measure (B-PROM)

Patients with Barrett's oesophagus (BO) carry significant cancer worry, burden of symptoms, and lack disease-specific knowledge. Currently there is no validated BO patient reported outcome measure (PROM) to measure these factors for use in clinical practice and research, hence the aim of this study was to devise a novel, validated BO-specific tool, B-PROM. Literature review, quantitative and qualitative research informed the initial item generation. The item bank was refined through a modified Delphi process between May and August 2021. The PROM was then tested through cognitive interviews and validated via multicentre testing between September 2021 and February 2023 with the aim to create a succinct tool which addresses the key important factors to BO patients and has strong psychometric properties. B-PROM covers key themes of disease-specific knowledge, trust in clinicians, burden of symptoms, cancer worry and burden of surveillance. Validation results from 387 participants (response rate 40.8%) showed 93.3% of participants completed >95% of B-PROM. All individual items scored a completion rate of >95%. Mean completion time was 5mins 34s for a sample group. Nineteen items showed a ceiling effect, 3 items showed a floor effect. Internal consistency overall demonstrated a Cronbach Alpha of 0.846, while predetermined subsections showed Cronbach alphas of 0.335, 0.718, 0.736, and 0.896. Inter-item analysis found 2 pairs of items with strong correlation, with only 6 items correlating weakly. Item-total correlation showed 19 items correlated well. Exploratory Factor analysis (EFA) with principal component analysis produced 5 components with Eigenvalues >1 of which 4/5 had satisfactory Cronbach alphas. Test-retest reliability showed no significant differences across single and average measures (p ≤ 0.001). B-PROM is the first BO-specific PROM to be systematically evaluated. Validation findings show strong internal consistency, short completion time, low missingness and excellent test-retest reliability. Medtronic Limited ISR-2016-1077.

Ten questions about cardiopulmonary exercise testing: all that the cardiologist dares or dares not to ask

In patients with cardiovascular, pulmonary, muscular and neurological diseases, cardiopulmonary exercise testing (CPET) is a valuable tool providing clinically-relevant diagnostic and prognostic information by evaluation of exercise response. CPET requires to be performed in dedicated centers able to correctly carry out the examination and to carefully evaluate the results. CPET analyzes functional capacity revealing both symptomatic and asymptomatic intolerance to exercise. One of the most important advantages for clinicians derived by the use of CPET, beyond standard exercise electrocardiography testing, is the capability not only to grade the severity of the disease, but also to distinguish between different causes of dyspnea and exercise impairment. Indications for CPET use in clinical practice are increasing in the last decades, evolving beyond the routine use as a training tool in athletes. In fact, CPET represents an important step in the management of patients with heart failure or pulmonary hypertension, as suggested by international guidelines. CPET role in helping for the selection of patients candidate to heart transplantation is also well known. Beyond its clinical usefulness, scientific interest in CPET is constantly expanding, mainly due to the safety of the exam and to the huge size of the pathophysiological information that it offers. The aim of this paper is to simply explain everyday applications and potential further purposes of CPET in clinical practice. Our review is intended both for physicians approaching CPET for the first time and for clinicians with an interest in expanding their knowledge in this field.

AI for Sustainable Farming

Abstract: Technology like the AI and IoT have been employed in farming for some time now, along with other forms of cutting-edge computer science. There has been a shift in recent years towards thinking about how to put this new technology to use. Agriculture has provided a large portion of humanity’s sustenance for thousands of years, with its most notable contribution being the widespread use of effective agricultural practices for several crop types. The advent of cutting edge IoT know-hows with the ability for monitoring agricultural ecosystems and guarantee high-quality production is underway. Smart Sustainable Agriculture continues to face formidable hurdles due to the widespread dispersion of agricultural procedures, such as the deployment4/ and administration of IoT and AI devices, sharing of data and administration, interoperability, and analysis and storage of enormous data quantities. The project aims to address pressing global challenges by promoting sustainable agriculture practices. Sustainable agriculture is characterized by its long-term viabilityand ecological compatibility, prioritizing the well-being of both humans and natural resources. It encompasses various techniques and methods that protect soil quality, conserve water resources, enhance biodiversity, and reduce greenhouse gas emissions.

Сравнение трибологических свойств алмазоподобного покрытия в паре со сталью / керамикой при сухом трении и граничной смазке

. Studies conducted in the last decade having proven experience of many years of practical use in friction units of various mechanisms and machines used in the national economy, have shown that the effective way to ensure their longevity, reliability and energy conservation is to apply DLC coatings on the friction surfaces of contacting parts in these friction nodes. It has now been established that the effectiveness of the use of these coatings is determined to a large extent by the conditions of their operation and the materials of the contacting parts. In the presented article, friction pairs are compared in terms of anti-friction properties, in which the studied steel samples with an amorphous DLC coating applied to steel through an intermediate layer of titanium aluminitride wear out under conditions of dry friction and film lubrication. Standard balls made of bearing chromium alloyed steel and ceramics based on silicon nitride are used as a wearing coupled element. Tribological experiments are carried out on the well-known laboratory installation KT-2 with an upgraded friction unit, which allows for the contact of a wearing ball with three horizontally positioned rollers, on the cylindrical surfaces of which the coating under study is applied. The article provides an analysis of the results of these experiments. In addition to DLC coating tests, data on tests of uncoated and coated samples with only a layer of titanium aluminitride are provided for comparison. A harder coupled element material can significantly affect the tribological properties, destroying coatings, thereby reducing the positive effects of the antifriction properties of coatings, and even lead to increased wear due to the formed abrasive particles in the friction zone.

Literature study: Comparative analysis of lead content in blood between spot workers, Caroseries industry workers, and metal smelting industry workers

Introduction: This study aims to analyze the comparison of lead content in blood between gas station attendants, bodywork industry workers, and metal smelting industry workers. Lead (Pb) is a heavy metal that can have dangerous effects on human health. Lead exposure can occur through various sources, including the work environment. Method: The research used is a literature study by collecting articles published between 2013-2023. After selection, there were 18 articles that were relevant to the research topic. Results and Discussion: The average lead content in the blood of gas station attendants ranges from 2.75 μg/dL to 35,317 μg/dL, bodywork industry workers range from 14.4 μg/dL to 35 μg/dL, and metal smelting industry workers range from 14.4 μg/dL. dL up to 50.83 μg/dL. Differences in levels of lead exposure between these three professions can be caused by differences in type of work, activities and work environment. Conclusion: Based on the results of this research, it can be concluded that gas station officers, bodywork industry workers, and metal smelting industry workers have different levels of exposure to lead. Therefore, appropriate health protection, such as the use of PPE and safe work practices, needs to be implemented to reduce the risk of lead exposure.

Broadband spin and angle co-multiplexed waveguide-based metasurface for six-channel crosstalk-free holographic projection

Metasurface-based holograms, or metaholograms, offer unique advantages including enhanced imaging quality, expanded field of view, compact system size, and broad operational bandwidth. Multi-channel metaholograms, capable of switching between multiple projected images based on the properties of illuminating light such as state of polarization and angle of incidence, have emerged as a promising solution for realizing switchable and dynamic holographic displays. Yet, existing designs typically grapple with challenges such as limited multiplexing channels and unwanted crosstalk, which severely constrain their practical use. Here, we present a new type of waveguide-based multi-channel metaholograms, which support six independent and fully crosstalk-free holographic display channels, simultaneously multiplexed by the spin and angle of guided incident light within the glass waveguide. We employ a k-space translation strategy that allows each of the six distinct target images to be selectively translated from evanescent-wave region to the center of propagation-wave region and projected into free space without crosstalk, when the metahologram is under illumination of a guided light with specific spin and azimuthal angle. In addition, by tailoring the encoded target images, we implement a three-channel polarization-independent metahologram and a two-channel full-color (RGB) metahologram. Moreover, the number of multiplexing channels can be further increased by expanding the k-space’s central-period region or combing the k-space translation strategy with other multiplexing techniques such as orbital angular momentum multiplexing. Our work provides a novel approach towards realization of high-performance and compact holographic optical elements with substantial information capacity, opening avenues for applications in AR/VR displays, image encryption, and information storage.

Inclusive Teaching Online: Lessons Learned

ABSTRACT This study aimed to understand how students with disabilities were included in online classrooms as teachers reimagined learning during COVID-19 school shutdowns. Through a mixed-methods approach, researchers investigated the implications of COVID-19 restrictions for private school teachers in Dubai, UAE. Dubai private schools provide many different curriculums but present a uniquely homogenous socio-economic school population to study, in addition to ongoing mandates for inclusion during the shift to at-home learning. The study addressed the adaptations made by teachers that could continue to influence practices in the return to in-person learning. Researchers utilised an explanatory-sequential mixed methods approach to data collection. Initial surveys explored the training and experience of teachers, while interview data brought forth the challenges and successes experienced. Quantitative data was analysed using SPSS software and included a factor analysis. The hypothesis tests for seven independent variables revealed several factors that could potentially lead to more successful outcomes. Qualitative results revealed a lack of adequate training and support for the use of inclusive practices and a need for teachers to reflect on pandemic teaching practices. Teachers reported many innovations and inclusive teaching methods; however, many of these new innovative, inclusive practices risk being lost if teachers do not engage in critical reflection.

Reinforcing Institutional Power: The Discourse of Normalcy in European Union Governance

Abstract This paper examines the notion of normalcy within the discourse of the European Union (EU), with a focus on its response to transformative dynamics and challenges, especially post-2008. I analyse how the EU, facing diminishing ideological supremacy, has reinforced its institutional power through the framework of normalcy. By emphasizing constitutionalisation and integration through legal means, bodies such as the European Court of Justice (ECJ) have expanded their roles, promoting "integration through law" to counter alternative political projects invariably labelled as populist, thereby giving rise to anti-populism as a discursive tool. Drawing on crisis discourse and diagnostic practice, this paper explores how normalcy legitimises and perpetuates existing power structures within EU governance, subtly coercing member states and citizens into accepting its norms and values, thus shaping perceptions of normalcy and also inevitability. At the core of this framework lies the rule of law (RoL), which establishes legal boundaries in the first place, but in the same move shapes political contexts.My paper argues that the exclusive focus on legalistic interpretations obscures the underlying structural factors perpetuating power dynamics and economic disparities among member states, constraining adaptive responses. I examine the narrative of "growing up to democracy" and its impact on the European project discourse, particularly in Central and Eastern European (CEE) countries. I then scrutinise the roles of experts and the “juristocracy” in reinforcing this narrative while simultaneously masking underlying inequalities and power differentials. Furthermore, the paper explores the strategic deployment of language and discourse by EU institutions during crises, highlighting their implications for public understanding, political action, and outcomes. Finally, it investigates the EU's strategic use of crisis discourse and diagnostic practices, focusing particularly on the ascendancy of the judiciary, but also highlighting how this trajectory may also have negative influence of legislative and executive bodies as their role diminishes in the process.

Practices to Improve the Sustainability of Australian Cold Storage Facilities

With the ever-increasing threat of climate change and global warming, ways to make energy intensive buildings, such as cold storage warehouses essential for food preservation, more sustainable need to be found. Some refrigerated warehouse owners may be unaware or unsure of the benefits obtainable from implementing sustainable practices and technologies. To search for innovations that could inform the owners and managers of cold storage warehouses about how to enhance their sustainability, convergent interviewing of subject matter experts was conducted. The resulting practices and processes were organized into a hierarchy that ranged from essential to best practices that can be implemented to improve the sustainability of refrigerated warehouses. Examples of these practices and technologies include ideal refrigeration systems, racking methods, and insulation types. To encourage the use of sustainable practices and technologies, more reporting on successful or unsuccessful applications of practices and technologies needs to be communicated. Applying change diagnostic tools such as convergent interviewing enables a practical and industry focused set of outcomes to be determined that can help drive change towards more sustainable cold storage warehouses in Australia.

Acceptability of corporal punishment and use of different parenting practices across high‐income countries

AbstractWorldwide, many children experience corporal punishment. Most research on corporal punishment has focused on parents' attitudes and use of corporal punishment; however, other relevant parenting factors and practices have rarely been examined. This study explored differences among countries with various levels of progress toward a total legal ban of corporal punishment in parents' acceptability of corporal punishment, perception of parenting as a private concern, relationship with their child and parenting practices: consistency, coercive parenting, use of smacking and positive encouragement. Parents (N = 6760) of 2‐ to 12‐year‐old children from Australia, Belgium, Canada, Germany, Hong Kong, Spain, Switzerland and the United Kingdom completed the International Parenting Survey, an online cross‐sectional survey. One‐way ANOVAs, and MANCOVAs (after controlling for parent age, gender and educational level), indicated significant country differences. Overall, there was no clear link between corporal punishment bans and positive parenting beliefs, practices and behaviours. The two countries where corporal punishment is banned showed different patterns. Parents in Germany showed less acceptability and use of smacking; however, parents in Spain reported the highest use of coercive parenting. Country differences suggest that beyond a legal ban, attention is needed on how to support parents to raise their children in a positive, nurturing environment.

Usability and feasibility of the Test of Adherence to Inhalers (TAI) Toolkit in daily clinical practice: The BANANA study

The Test of Adherence to Inhalers (TAI) Toolkit links an adherence measurement instrument (the TAI) to proven effective interventions for different causes of non-adherence to inhaled medication. This study aimed to assess the usability and feasibility of the TAI Toolkit in clinical practice. The TAI Toolkit was piloted in eight primary and secondary care settings. Each study site included 10 patients with asthma and/or COPD and suspected non-adherence. Healthcare professionals (HCPs) recorded clinical data and TAI Toolkit outcomes. Data on usability and feasibility were collected in semi-structured interviews and with the System Usability Score (SUS). Of the included patients, 81% were non-adherent, and sporadic non-adherence was the most common (69%). The TAI Toolkit was valued with a mean SUS-score of 85.9 by the HCPs. They found the toolkit to ‘be visually attractive’, ‘easy-to-use’ and ‘give insight into patients’ adherence’, thereby offering good potential for its use in clinical practice.

Nurse-sensitive quality and benchmarking in hospitals striving for Magnet® or Pathway® designation: A qualitative study.

To examine if and how selected German hospitals use nurse-sensitive clinical indicators and perspectives on national/international benchmarking. Qualitative study. In 2020, 18 expert interviews were conducted with key informants from five purposively selected hospitals, being the first in Germany implementing Magnet® or Pathway®. Interviews were analyzed using content analysis with deductive-inductive coding. The study followed the COREQ guideline. Three major themes emerged: first, limited pre-existence of and necessity for nurse-sensitive data. Although most interviewees reported data collection for hospital-acquired pressure ulcers and falls with injuries, implementation varied and interviewees highlighted the necessity to develop additional nurse-sensitive indicators for the German context. Second, the theme creating an enabling data environment comprised building clinicians' acceptance, establishing a data culture, and reducing workload by using electronic health records. Third, challenges and opportunities in establishing benchmarking were identified but most interviewees called for a national or European benchmarking system. The need for further development of nurse-sensitive clinical indicators and its implementation in practice was highlighted. Several actions were suggested at hospital level to establish an enabling data environment in clinical care, including a nationwide or European benchmarking system. Involving nurses in data collection, comparison and benchmarking of nurse-sensitive indicators and their use in practice can improve quality of patient care. Nurse-sensitive indicators were rarely collected, and a need for action was identified. The study results show research needs on nurse-sensitive indicators for Germany and Europe. Measures were identified to create an enabling data environment in hospitals. An initiative was started in Germany to establish a nurse-sensitive benchmarking capacity. Clinical practitioners and nurse/clinical managers were interviewed.

Probiotics for Aquaculture: Hope, Truth, and Reality.

The use of microorganisms as beneficial crops for human and animal health has been studied for decades, and these microorganisms have been in practical use for quite some time. Nowadays, in addition to well-known examples of beneficial properties of lactic acid bacteria, bifidobacteria, selected Bacillus spp., and yeasts, there are several other bacteria considered next-generation probiotics that have been proposed to improve host health. Aquaculture is a rapidly growing area that provides sustainable proteins for consumption by humans and other animals. Thus, there is a need to develop new technologies for the production practices associated with cleaner and environment-friendly approaches. It is a well-known fact that proper selection of the optimal probiotics for use in aquaculture is an essential step to ensure effectiveness and safety. In this critical review, we discuss the evaluation of host-specific probiotics in aquaculture, challenges in using probiotics in aquaculture, methods to improve the survival of probiotics under different environmental conditions, technological approach to improving storage, and delivery along with possible negative consequences of using probiotics in aquaculture. A critical analysis of the identified challenges for the use of beneficial microbes in aquaculture will help in sustainable aquafarming, leading to improved agricultural practices with a clear aim to increase protein production.

Grower assessment of profitability impact from Brown Marmorated Stink Bug, Halyomorpha halys (Stål), the value of management information sources, and use of potential management practices

AbstractAn online survey was conducted from June 2018 to March 2021 to elicit information from commercial farmers and growers on the economic impact of the Brown Marmorated Stink Bug (BMSB) (Halyomorpha halys (Stål)) on agriculture and their attitudes towards adopting various alternative management practices, including use of Trissolcus japonicus as a biocontrol agent. Most respondents reported that BMSB reduced the profitability of their operation, with the largest impacts coming from reduced quality and increased spray cost. Improved monitoring techniques and natural enemies have the greatest probability to be used to manage BMSB, while tactics like attract and kill, border sprays, repellents, trap crops and netting were less likely to be adopted. Further analysis using ordered logistic and tobit regression models shows that the factors that influence potential adoption vary significantly for each management practice. This suggests that adoption efforts for alternate management practices should focus on the attributes of specific commodity groups and targeted educational programmes may be required to overcome the resistance of growers using conventional growing practices. Several variables have a consistent impact on the respondent's willingness to pay for a T. japonicus‐based biocontrol including being a commercial producer (positive impact), use of conventional growing practices (negative) and increased concern about the impact of BMSB (positive).

ChatGPT and the German board examination for ophthalmology: an evaluation

In recent years artificial intelligence (AI), as anew segment of computer science, has also become increasingly more important in medicine. The aim of this project was to investigate whether the current version of ChatGPT (ChatGPT4.0) is able to answer open questions that could be asked in the context of aGerman board examination in ophthalmology. After excluding image-based questions, 10questions from 15different chapters/topics were selected from the textbook 1000 questions in ophthalmology (1000 Fragen Augenheilkunde 2ndedition, 2014). ChatGPT was instructed by means of aso-called prompt to assume the role of a board certified ophthalmologist and to concentrate on the essentials when answering. Ahuman expert with considerable expertise in the respective topic, evaluated the answers regarding their correctness, relevance and internal coherence. Additionally, the overall performance was rated by school grades and assessed whether the answers would have been sufficient to pass the ophthalmology board examination. The ChatGPT would have passed the board examination in 12out of 15topics. The overall performance, however, was limited with only 53.3% completely correct answers. While the correctness of the results in the different topics was highly variable (uveitis and lens/cataract 100%; optics and refraction 20%), the answers always had ahigh thematic fit (70%) and internal coherence (71%). The fact that ChatGPT4.0 would have passed the specialist examination in 12out of 15topics is remarkable considering the fact that this AI was not specifically trained for medical questions; however, there is aconsiderable performance variability between the topics, with some serious shortcomings that currently rule out its safe use in clinical practice.