Dysregulation of redox- sensitive signaling plays an important role in develompment of hypertension. PPAR gamma belongs to nuclear receptors and is a potent nutritional sensor and redox regulator. In our study we focused on the role of PPAR gamma activation of RAS/ROS regulation, and antioxidant response in spontaneously hypertensive rats (SHR). Treatment was performed by gavage with PPAR gamma agonist pioglitazone (PIO - 10 mg/kg/day, 10 days). Treatment with PPAR gamma agonist PIO in influenced blood pressure, redox- sensitive responses, lipid profile and homocystein level in age- dependent manner. The improvement parameters in hypertension and redox regulation have been observed in young animals, but not in adult SHR rats. PIO treatment influenced redox regulation (gene expression of Nrf2 and SOD isoforms) correlated with SOD a CAT activity and NO bioavailibility. PPAR gamma activation has been corelated with downregulation of and AT1R - RAS axis and „up-regulation“ of AT2R and Mas receptor. This most sensitive tissue responses in RAS/ROS signaling and NO level have been found primary in kidney of young hypertensive rats.