Insecticides applied with a power sprayer to replicated field plots of flue-cured tobacco in 1968–72 were evaluated vs. artificial infestations of Heliothis virescens (F.) of similar insecticidal susceptibility. Significantly less control of budworm larvae and damage was obtained with methomyl in early 1970 than in 1968–69, 1971–72, and late 1970. In early 1970, methomyl provided 35 and 25% control of larvae and damage, respectively. In the other seasons, control of larvae and damage with methomyl averaged 82 and 72%, respectively. When tested in early 1970, carbaryl, endosulfan, monocrotophos, Supracide® (O,O-dimethyl phosphorodithioate, S-ester with 4-[mercaptomethyl]-2-methoxy-Δ2-1,3,4-thiadiazolin-5-one), TDE, and Thuricide HP® ( Bacillus thuringiensis Berliner) also performed poorly vs. the tobacco budworm. The abnormally low insecticidal control obtained in early 1970 appeared to be related to low rainfall and low relative humidity. Observations suggest that the effects of low moisture on tobacco plants and budworm larvae reduced the effectiveness of insecticides.