ABSTRACT Introduction: The oxygen uptake ( V ˙ O2) vs power output relationship from ramp incremental exercise is used to prescribe aerobic exercise. As power output increases, there is a delay in V ˙ O2 that contributes to a misalignment of V ˙ O2 from power output; the mean response time (MRT). If the MRT is not considered in exercise prescription, ramp incremental-identified power outputs will elicit V ˙ O2 values that are higher than intended. We compared three methods of determining MRT (exponential modeling (MRTEXP), linear modeling (MRTLIN), and the steady-state method (MRTSS)) and evaluated their accuracy at predicting the V ˙ O2 associated with power outputs approximating 75% and 85% of gas exchange threshold and 15% of the difference between gas exchange threshold and maximal V ˙ O2 (Δ15). Methods: Ten males performed a 30-W∙min−1 ramp incremental and three 30-min constant power output cycle ergometer trials with intensities at 75% gas exchange threshold, 85% gas exchange threshold, and ∆15. At each intensity, the measured steady-state V ˙ O2 during each 30-min test was compared to the V ˙ O2 predicted after adjustment by each of the three MRTs. Results: For all three MRT methods, predicted V ˙ O2 was not different (p = 1.000) from the measured V ˙ O2 at 75%GET (MRTEXP, 31 mL, MRTLIN, −35 mL, MRTSS 11 mL), 85%gas exchange threshold (MRTEXP −14 mL, MRTLIN −80 mL, MRTSS −32 mL). At Δ15, predicted V ˙ O2 based on MRTEXP was not different (p = .767) from the measured V ˙ O2, but was different for MRTLIN (p < .001) and MRTSS (p = .03). Conclusion: Given that the intensity is below gas exchange threshold, all model predictions implemented from the current study matched the exercise prescription.