The electric power industry is an important chain in the energy revolution and one of the most important basic industries. At the same time, it is also facing the technology collision and industry innovation brought by various emerging technologies, which constantly promotes the development of the electric power industry in the direction of safety, intelligence and cleanness. Power grid enterprises have a great demand for scientific research and innovation, and the average annual investment in scientific research has exceeded 100 million yuan. With the increasing investment in scientific research and development of power enterprises year by year, the demand for systematic, scientific and efficient management system for scientific and technological projects is becoming increasingly urgent. In view of the shortcomings of the traditional project management mode, this study establishes the corresponding management and evaluation mechanism by combining with the whole life cycle management method of modern project management, realizes the transformation of power enterprise science and technology project management to high efficiency, high quality, specialization and scientization, and promotes the innovation and integration development of traditional technology and emerging technology. The all life-cycle management mode has been widely applied in major power grid projects. By integrating superior resources, breaking through major engineering technology research and development, giving full play to the innovation of projects and avoiding research and development risks, it explores the development direction of science and technology project management in energy industry and improves the industry management level.