With the introduction of the "carbon peak, carbon neutrality" action plan, it has become an inevitable trend to invest in promoting supply-side structural adjustment and demand-side response to achieve bilateral development. Therefore, the construction expansion and construction cost assessment of key areas of power grid in the future are the focus of power enterprises. In this paper, a comprehensive evaluation model of regional power grid construction cost suitable for various environments is proposed. The ANP-CRITIC method, which combines the analytic hierarchy process with the CRITIC objective evaluation method, is used to determine the subjective and objective weights of the indicators. The comprehensive evaluation results are obtained by calculating the combined weights based on Euclidean distance. In terms of model verification, based on PEST theory, this paper constructs a regional power grid construction cost index system from 4 levels: political environment, economic environment, social environment and technical environment. Through the evaluation and analysis of regional examples, the rationality of the model is verified, and the lowest expected construction cost area is selected to assist enterprise decision-making and ensure the effective realization of power grid construction benefits.