Tithonia biomass transfer was presented as a technology that would replenish infertile soils, enhance food security and eradicate poverty in Africa in the 1990s. Since then, a huge volume of research has been conducted and the agronomic effectiveness of tithonia unequivocally demonstrated. Its reported effects on soil properties have however been inconsistent. This has made it difficult to develop a predictive understanding of the effects of tithonia on soil properties. Socio-economically, tithonia failed to live up to the hype on its ability to increase the farmers’ incomes. Adoption rates have been dismal mainly because of high labor costs associated with its use. Two decades later, poverty and food insecurity are still widespread in Africa despite the enormous research and extension efforts that were devoted to popularizing the technology.