Potential Actions Research Articles

Brand Blunders and Race in Advertising: Issues, Implications, and Potential Actions from a Macromarketing Perspective

This pedagogic commentary introduces the concept of “brand blunders” to the macromarketing literature and considers the interaction between advertising, race, and society from a macromarketing perspective. We first analyze relevant literature on cultural stereotyping in advertising for both gender and race, and evaluate consumer responses to ideologies in advertisements. Three prominent recent racial controversies are selected to examine the nature of the advertising imagery, consumer interpretations of the advertisements in question, and the company responses to the public furor created by these campaigns. We then consider the issues, implications, and potential actions for macromarketing raised by these examples, and some key research questions that arise for future macromarketing scholarship. The commentary is intended to provide macromarketing educators with a summary of the key knowledge base on the relationship between advertising, race, and society, for use in courses in advertising, brand management, consumer research, innovation management, marketing communications, and marketing strategy.

Ponzi scheme like investment schemes in India – causes, impact and solution

PurposeNews items like “A whopping 2 lakh gullible investors were cheated…….” amply illustrate the extent of problems and hardships caused by financial frauds related to Ponzi schemes, collective investment schemes (CIS), unregulated deposit schemes, etc. In India, over the years, many Ponzi and unregulated investment schemes have taken place, causing huge economic and financial loss to Indian economy. This paper aims to examine why investment such schemes like Ponzi schemes and CIS become popular, how such schemes got operated in different periods and what could be done to safeguard the interests of investors.Design/methodology/approachThe analysis is done based on secondary data and research work of various researchers, organisation and institutions, which are available in the public domain.FindingsThis paper has tried to analyse various characteristics of such fraudulent schemes, like their modus operandi, promotional activity, background of promoters and legal process involved in recouping financial loss of millions of investors. This paper also examines the demand-side factors that are responsible for popularity of those schemes in India. Noting the regulatory changes and other initiative taken by regulatory authorities to control the supply of unregulated investment schemes, this paper indicates potential actions, which could be undertaken to make people aware about the risks and issues related with such fraudulent schemes.Originality/valueThis paper gives an overview about various aspects of unregulated investment schemes, which have duped numerous people at different point of time. To the best of the authors’ knowledge, this research work is original and has not been published in any other journal.

Literature review on maritime cybersecurity: state-of-the-art

AbstractMaritime cybersecurity has attracted increasing attention in industrial and academic scope, which may be relevant to the increasing cyber-incidents in the maritime shipping industry. This paper presents a critical review of publications related to cybersecurity in the maritime transportation industry, to explore the current research status and gaps, as wells as to guide new probe avenues by employing bibliometric approaches. With the advantage of bibliometric methods, the research focus and evolution are conformed and visualised. Representative papers are reviewed together to demonstrate maritime cyber-threats recognition and categories, as well as potential consequence assessment and risk mitigation actions recommendation. This paper also created a detailed database that is comprised of attack form, occurring time, targets, purpose, as well as potential results and cost, which has been included in the Appendix and is fully portable and extendible.

Meloxicam Targets COX-2/NOX1/NOX4/Nrf2 Axis to Ameliorate the Depression-like Neuropathology Induced by Chronic Restraint Stress in Rats.

Meloxicam has shown significant neuroprotection in experimental models of stroke, Alzheimer's disease, and Parkinson's disease. However, the potential of meloxicam to treat depression-like neuropathology in a chronic restraint stress (CRS) model and the associated molecular changes has been insufficiently explored. The current work aimed to explore the potential neuroprotective actions of meloxicam against CRS-evoked depression in rats. In the current experiments, animals received meloxicam (10 mg/kg/day; i.p.) for 21 days, and CRS was instigated by restraining the animals for 6 h/day during the same period. The sucrose preference test and the forced swimming test were used to explore the depression-linked anhedonia/despair, whereas the open-field test examined the animals' locomotor activity. The current findings revealed that CRS elicited typical depression behavioral anomalies in the animals, including anhedonia, despair, and diminished locomotor activity; these findings were reinforced with Z-normalization scores. These observations were corroborated by brain histopathological changes and increased damage scores. In CRS-exposed animals, serum corticosterone spiked, and the hippocampi revealed decreased monoamine neurotransmitter levels (norepinephrine, serotonin, and dopamine). Mechanistically, neuroinflammation was evident in stressed animals, as shown by elevated hippocampal TNF-α and IL-1β cytokines. Moreover, the hippocampal COX-2/PGE2 axis was activated in the rats, confirming the escalation of neuroinflammatory events. In tandem, the pro-oxidant milieu was augmented, as seen by increased hippocampal 8-hydroxy-2'-deoxyguanosine alongside increased protein expression of the pro-oxidants NOX1 and NOX4 in the hippocampi of stressed animals. In addition, the antioxidant/cytoprotective Nrf2/HO-1 cascade was dampened, as evidenced by the lowered hippocampal protein expression of Nrf2 and HO-1 signals. Interestingly, meloxicam administration mitigated depression manifestations and brain histopathological anomalies in the rats. These beneficial effects were elicited by meloxicam's ability to counteract the corticosterone spike and hippocampal neurotransmitter decrease while also inhibiting COX-2/NOX1/NOX4 axis and stimulating Nrf2/HO-1 antioxidant pathway. Together, the present findings prove the neuroprotective/antidepressant actions of meloxicam in CRS-induced depression by ameliorating hippocampal neuroinflammation and pro-oxidant changes, likely by modulating COX-2/NOX1/NOX4/Nrf2 axis.

Opportunities for Improving Herbicide Resistance Management Strategies across New Zealand’s Arable Sector

Herbicide resistance is increasingly recognised as a challenge for agricultural producers worldwide. International scholarship and practical experiences suggest that collective efforts by diverse agricultural stakeholders are crucial for effective resistance management. In New Zealand, such sector-wide initiatives and strategies remain fragmented, partly due to a lack of state coordination and national extension services. This article synthesises insights from three complementary social research methods involving actors across the country’s arable-crop-growing sector (focus groups, semi-structured interviews, and an industry workshop) to identify pathways to foster collaboration and more strategic resistance management. The presented findings detail challenges, opportunities, and potential actions across four domains: strengths and weaknesses of New Zealand’s farming context, better information and knowledge exchange, improved collaboration and coordination, and targeted education and training. Our analysis highlights that most opportunities described within these domains involve purposely strengthening existing, or forming new, social and institutional relationships as part of establishing resistance management as a shared sector responsibility. A portfolio of multipronged initiatives and programmes is then required for effective whole-industry strategies. We discuss potential next steps to collectively realise identified opportunities, from more immediately feasible steps to long-term activities. These insights conceptually contribute to the international scholarship on herbicide resistance by reinforcing the notion that industry leadership and meaningful farmer involvement are indispensable for more collaborative approaches aimed at strategically managing resistance.

When Independence Meets Reality: Symbolic and Pragmatic Politics in Taiwan

ABSTRACT In Taiwan, where relations with China define the major political cleavage, voters have distinct preferences on the issue of independence. Do Taiwanese favor a symbolic or pragmatic approach to the Taiwan independence issue? What are the factors that account for their political preferences? We identify two types of voters, symbolic and pragmatic, according to whether their preferences on independence are conditional or unconditional on China’s potential counter actions. Specifically, symbolic voters have unconditional preferences on independence, while pragmatic voters are more agreeable to independence under more favorable conditions. Using multiple wave data from the Taiwan National Security Surveys (TNSS 2002–2022), we investigate the individual- and macro-level factors and find that gender, age, education level, ethnicity, partisan strength, and economic growth rate shape the types of voters in Taiwan. This paper contributes to the study of political attitudes in Taiwan, and have important implications on the regional stability in East Asia.

A review on the edible mushroom as a source of special flavor: Flavor categories, influencing factors, and challenges

AbstractEdible mushrooms are highly valued for both their culinary and medicinal properties. Unlike traditional condiments, the complex flavor of mushrooms is not determined by a single component, but rather by the potential synergistic actions of several different components and chemical interactions. However, only a limited number of edible mushroom flavor compounds have been examined in detail, leading to an incomplete understanding of their overall flavor profile. To address this knowledge gap, it is necessary to conduct further scientific research on edible mushroom flavors to maximize their utilization. This review aims to provide a comprehensive overview of the flavor substances found in edible mushrooms, including both volatile and nonvolatile compounds, as well as the mechanisms by which various processing methods affect flavor. Additionally, we will explore the various factors that hinder the development of edible mushroom flavors and recommend strategies to further advance the technological and theoretical understanding of these unique and valuable food ingredients. In summary, by enhancing our understanding of the complex and unique flavor profile of edible mushrooms, we can better leverage their full potential as a valuable culinary and medicinal resource.

Estimating population viability of the northern Great Plains piping plover population considering updated population structure, climate change, and intensive management

One challenge in wildlife conservation is understanding how various threats and management actions may influence long-term population viability. This is particularly evident when there is considerable uncertainty regarding population structure and vital rates. Reassessment of current knowledge and population trends is necessary for listed species to improve management actions that benefit conservation. We present an updated population viability analysis for northern Great Plains piping plovers (Charadrius melodus circumcinctus) based on the latest scientific data on survival, fecundity, and connectivity. Further, we explore the consequences of potential management actions and the stochastic effects of global climate change on population viability through changes in survival and fecundity. Our results predict elevated risks of extinction after 50 years (0.088 – 0.373) compared to previous predictions (0.033) based on assumed conditions of low connectivity among four major breeding groups structured as a metapopulation. We explored eight scenarios based on empirically-derived, higher connectivity rates and found that the northern Great Plains population never had a mean predicted population growth rate greater than one (0.946 – 0.996). Two scenarios that simulated a reduction in adult survival showed higher extinction probabilities (0.267 – 0.373), whereas two other scenarios that simulated an increase in fecundity exhibited lower extinction probabilities (0.088 – 0.103). These results indicate that viability of the northern Great Plains population of piping plovers could be improved with management actions that increase fecundity as long as adult survival is not simultaneously reduced. Lastly, breeding groups appeared to function less independently when connectivity rates were higher, as the breeding population was divided evenly among breeding groups. This indicates that the presumed metapopulation structure of our study system may need to be re-evaluated, and that empirically-based estimates of connectivity are essential to assessing population viability of mobile species that exhibit a spatially structured distribution.

Microalgae, Seaweeds and Aquatic Bacteria, Archaea, and Yeasts: Sources of Carotenoids with Potential Antioxidant and Anti-Inflammatory Health-Promoting Actions in the Sustainability Era

Carotenoids are a large group of health-promoting compounds used in many industrial sectors, such as foods, feeds, pharmaceuticals, cosmetics, nutraceuticals, and colorants. Considering the global population growth and environmental challenges, it is essential to find new sustainable sources of carotenoids beyond those obtained from agriculture. This review focuses on the potential use of marine archaea, bacteria, algae, and yeast as biological factories of carotenoids. A wide variety of carotenoids, including novel ones, were identified in these organisms. The role of carotenoids in marine organisms and their potential health-promoting actions have also been discussed. Marine organisms have a great capacity to synthesize a wide variety of carotenoids, which can be obtained in a renewable manner without depleting natural resources. Thus, it is concluded that they represent a key sustainable source of carotenoids that could help Europe achieve its Green Deal and Recovery Plan. Additionally, the lack of standards, clinical studies, and toxicity analysis reduces the use of marine organisms as sources of traditional and novel carotenoids. Therefore, further research on the processing of marine organisms, the biosynthetic pathways, extraction procedures, and examination of their content is needed to increase carotenoid productivity, document their safety, and decrease costs for their industrial implementation.

Personalized precision combination therapies based on potential actionability and coalterations and therapeutic opportunities for CDK12-mutated prostate cancer.

e17068 Background: Translational studies have reported that CDK12 aberrations in metastatic castration-resistant prostate cancer (mCRPC) are related to homologous recombination (HR) deficiency and focal tandem duplications(FTDs), characterized by gene fusions and fusion-induced neoantigens (FINAs). In prostate cancer,CDK12 aberrations as a biomarker have been reported associated with poor prognosis, whether hormonal and taxane therapies as well as to PARP inhibitors. Herein, we aimed to molecularly, pathologically, and clinically characterize CDK12-aberrant mCRPC. Methods: Clinical data and molecular analyses are collected from the mCRPC patients treated in our center. Thirty-two patients with prostate cancer underwent soft tissue biopsy or sufficient ctDNA(Circulating Tumor DNA) for NGS and confirmed the CDK12 aberrations. Twenty-eight patients had advanced to the stage of mCRPC, and twenty-seven of them had exhausted standard treatment.All of the twenty-seven patients consented to the individualized therapiees based on NGS.PSA50 response rate and progression-free survival(PFS) are used to describe clinical features and outcomes to various individualized therapies, including sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) and PD-1/PD-L1 inhibitors monotherapy or combined with other off-label drugs. Results: Of the 32 patients with CDK12-aberrant prostate cancer, 19(59.4%) had detected biallelic CDK12 alterations. At diagnosis,17 (68%) patients' PSA≥100ng (only 26 patients retained the PSA data), 27 (93.1%) had Gleason grade group 4-5(only 29 patients retained the pathology),16(51.6%) had lymph node metastasis, 16(51.6%) had bone metastasis.13 patients received PARPi combine NHT(Novel hormone therapy) or not after NHT therapy resistance,only 1 patient PSA response reached PSA50.9 patients received PARPi combine temozolomide,2 reached PSA50,1 patient's liver metastases were significantly reduced ang reached PR.In that five patients,4 of 5 were monotherapied by PARPi.21 patients accepted PD-1/PD-L1 combined with PARPi or other off-label drugs based on the NGS or not.Four patients accepted immune monotherapy,only 1 reached PSA50. In the remaining 17 combined treatment patients, PSA50 responses were noted in 23.5%. What is noteworthy is that,4 of 16 happened HPD(hyperprogressive disease) with clinical manifestations such as rapid increase of PSA and significant decrease of ECOG score. Conclusions: CDK12-aberrant mCRPC is an aggressive subtype and have worse prognosis to PARPi. PARPi combine with temozolomide may be a effective therapeutic schedule. Along with NGS development,more therapeutic drugs are available to us to benefits for patients.But immunotherapy is questionable to CDK12-aberrant mCRPC because of the lower response rate and higher risk of HPD.

Real-time customized precision combination therapies based on potential actionability and coalterations to provide therapeutic opportunities for hyperprogressive disease after immune checkpoint inhibitor therapy.

e14688 Background: Patients with hyperprogressive disease (HPD) after immune checkpoint inhibitor therapies have few treatment options and short survival times. Genomic-based precision medicine within the frame of molecular tumor board might theoretically enable effective treatment identification for HPD. Detailed data on MTB guided treatments and outcome with a focus on HPD have not been reported yet. Methods: This is a single-institution retrospective, open-label, histology-agnostic analysis of the consecutively identified HPD patients that have received a real-time precision combination treatment approach which would rapidly integrate clinical grade targeted next-generation sequencing, NGS interpretation and with or without patient-derived xenografting to identify and prioritize effective customized targeted combination treatments within the frame of molecular tumor board at the Tianjin Medical University Second Hospital, a single large academic medical center, refractory cancer-foucused, between January 2018 and January 2022. Treatment was selected using on-label, off-label or investigational agents either in monotherapy or in combination. Clinicopathologic data, next-generation sequencing results, MTB recommendations, therapy received, outcomes, response assessment based on radiologic imaging and follow-up data were assessed through database searching. Results: A total of 41 HPD suspected patients were referred to the MTB, and 38 conformed HPD with one of the criteria of Russo or Kato. 27 patients were treated with MTB recommended targeted mono or combinational therapy, 4 in accordance with guidelines (on label) in clinical practice, and 23 off label within two ongoing real-time precision medicine programme for patients with exhausted standard care. Of 25 evaluable patients, 20 (80%) achieved either partial response (n = 13, 52%) or stable disease (n = 7, 28%) and with a median overall survival of 12.2 months (95% CI, 8.4 months to not reached). Furthermore, 14 (56%) of those patients showed improvement in progression-free survival of at least 30% while on MTB-recommended treatment compared with the progression-free survival of the previous treatment line. Conclusions: It represents a proof of-concept case series as it demonstrates the feasibility of real time precision approach in the clinical setting and guide individual patient treatment in the rare and high aggressive disease. Patients with MTB-recommended treatments seemed to benefit with respect to PFS ratio and OS.

A Survey on Active Simultaneous Localization and Mapping: State of the Art and New Frontiers

Active simultaneous localization and mapping (SLAM) is the problem of planning and controlling the motion of a robot to build the most accurate and complete model of the surrounding environment. Since the first foundational work in active perception appeared, more than three decades ago, this field has received increasing attention across different scientific communities. This has brought about many different approaches and formulations, and makes a review of the current trends necessary and extremely valuable for both new and experienced researchers. In this article, we survey the state of the art in active SLAM and take an in-depth look at the open challenges that still require attention to meet the needs of modern applications. After providing a historical perspective, we present a unified problem formulation and review the well-established modular solution scheme, which decouples the problem into three stages that identify, select, and execute potential navigation actions. We then analyze alternative approaches, including belief-space planning and deep reinforcement learning techniques, and review related work on multirobot coordination. This article concludes with a discussion of new research directions, addressing reproducible research, active spatial perception, and practical applications, among other topics.

Prioritizing urban nature-based solutions to support scaling-out strategies: A case study in Las Palmas de Gran Canaria

Nature-based solutions (NbS) can synergistically improve human well-being and biodiversity in urban areas by enhancing ecosystem functions and services. Scaling out NbS, understood as the widespread application of NbS in multiple contexts, is an important policy ambition to increase the number of people and regions benefiting from NbS. However, designing scaling-out strategies requires considering critical aspects of the nexus between NbS and ecosystem services (ES) supply to yield large-scale benefits effectively. The aim of the study is twofold: (i) to simulate the stepwise implementation of multiple NbS and (ii) to quantify their cumulative impacts on ES supply and beneficiaries. The NbS implementation was guided by a method that prioritizes different NbS types in multiple sites, by combining spatial information on ES demand and land suitability with a qualitative description of ES supply by NbS type. The cumulative impacts were computed stepwise using GIS modeling. The study was conducted in Las Palmas de Gran Canaria (Spain), focusing on five types of NbS (urban forests, urban parks, community gardens, infiltration ponds), and five ES (runoff mitigation, stormwater treatment, soil erosion control, recreation, and food supply). Overall, 179 NbS were simulated in 130 sites distributed in the city. The findings showed an improvement in all services, albeit significant increments occurred only for certain services. We observed a non-linear relationship between NbS and impacts, including constant, positive, and negative trends. We discussed several factors that were determinants of impacts, providing insights on how to design scaling-out strategies from the biophysical perspective. Moreover, we reflected on the role of multifunctionality, social preferences, and economic feasibility as prioritization criteria for NbS. Finally, we addressed the implementation of NbS scaling-out strategies from a broader perspective, deepening governance, economic and planning challenges, and potential actions for the case study.

Enabling technologies for circular economy in the construction sector

Enabling Technologies have the potential to transform both the physical flow of materials and resources (production and construction methods), and the intangible organisational and managerial relationships (exchange and monitoring of data and relationships along the entire chain of value). They should, therefore, be considered important in supporting change processes aimed at the circular use of resources. This paper presents some research and experiments, at European and Italian level, aimed at developing and applying Enabling Technologies for circular economy, and at aligning them with the needs and challenges of society, by directly involving actors of the building sector ecosystem in moments of discussion and co-creation to define potential strategies and operational actions for innovation in the sector.

Exploring the Impact of Cyanidin-3-Glucoside on Inflammatory Bowel Diseases: Investigating New Mechanisms for Emerging Interventions.

Cyanidin-3-O-glucoside (C3G), the most widely distributed anthocyanin (ACN) in edible fruits, has been proposed for several bioactivities, including anti-inflammatory, neuro-protective, antimicrobial, anti-viral, anti-thrombotic and epigenetic actions. However, habitual intake of ACNs and C3G may vary widely among populations, regions, and seasons, among individuals with different education and financial status. The main point of C3G absorption occurs in the small and large bowel. Therefore, it has been supposed that the treating properties of C3G might affect inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD). IBDs develop through complex inflammatory pathways and sometimes may be resistant to conventional treatment strategies. C3G presents antioxidative, anti-inflammatory, cytoprotective, and antimicrobial effects useful for IBD management. In particular, different studies have demonstrated that C3G inhibits NF-κB pathway activation. In addition, C3G activates the Nrf2 pathway. On the other hand, it modulates the expression of antioxidant enzymes and cytoprotective proteins, such as NAD(P)H, superoxide dismutase, heme-oxygenase (HO-1), thioredoxin, quinone reductase-oxide 1 (NQO1), catalase, glutathione S-transferase and glutathione peroxidase. Interferon I and II pathways are downregulated by C3G inhibiting interferon-mediating inflammatory cascades. Moreover, C3G reduces reactive species and pro-inflammatory cytokines, such as C reactive protein, interferon-γ, tumor necrosis factor-α, interleukin (IL)-5, IL-9, IL-10, IL-12p70, and IL-17A in UC and CD patients. Finally, C3G modulates gut microbiota by inducing an increase in beneficial gut bacteria and increasing microbial abundances, thus mitigating dysbiosis. Thus, C3G presents activities that may have potential therapeutic and protective actions against IBD. Still, in the future, clinical trials should be designed to investigate the bioavailability of C3G in IBD patients and the proper therapeutic doses through different sources, aiming to the standardization of the exact clinical outcome and efficacy of C3G.

Promising Insecticidal Properties of Essential Oils from Artemisia aragonensis Lam. and Artemisia negrei L. (Asteraceae) by Targeting Gamma-Aminobutyric Acid and Ryanodine Receptor Proteins: In Vitro and In Silico Approaches

Artemisia negrei (A. negrei) and Artemisia aragonensis (A. aragonensis) are in the family Asteraceae, which has been used in traditional medicine. The use of plant-derived insecticides has become a promising strategy to reduce the harmful effects of synthetic insecticides and overcome the bio-resistance of pest insects to insecticides. In this regard, the purpose of the current study was to determine the chemical composition and evaluate insecticidal effects of essential oils (EOs) extracted from A. negrei (EON) and A. aragonensis (EOA). Notably, all chemical constituents present in the EOs were identified through GC-MS analysis, whilst the insecticidal properties against Callosobruchus maculatus Fab. (C. maculatus) were investigated by use of in vitro an in silico approaches. The obtained results showed that both tested EOs present a significant insecticidal effect against C. maculatus, which increased significantly upon the dose used in both contact and inhalation tests. The lethal concentrations (LC50) for the inhalation test were found to be 2.1 and 2.97 μL/L, while in the contact test they were 2.08 and 2.74 μL/L of air for EON and EOA, respectively. At 5 μL/L of air, the spawn reduction rate was 88.53 % and 77.41%, while the emergence reduction rate was 94.86% and 81.22% by EON and EOA, respectively. With increasing doses of up to 20 μL/L of air, the reduction in individual emergence reached 100% by the two oils tested after 36 h of treatment. In addition, Molecular docking (MD) simulations supported the in vitro findings and indicated that certain identified components in EOA and EON exhibited stronger hydrogen bonding interactions with the target receptors. Interestingly, the prediction of ADMET properties indicates that the molecules investigated have great pharmacokinetic profiles with no side effects. Taken together, our findings suggest that EOA and EON may exert both potential contact and inhalation insecticidal actions and could be used as an alternative tool for the control of this major insect pest of stored products.

Valorizing staple Native American food plants as a food resilience resource

IntroductionIncreased risks from global climate change and sun-blocking global catastrophic risks (such as a nuclear winter), warrant the reevaluation of our food systems and their resilience to these climatic changes. Increasing native agrobiodiversity is a simple way of increasing food system resilience, and despite the vast amount of native genetic resources available in North America, the United States has shown little systematic effort to improve its agrobiodiversity.MethodsWe use a systematic literature review of staple Native American food plants (NAFPs) to determine the current state of research interest among them and suggest species of interest for domestication. The nutrient profiles and nutrient adequacy scores for the most researched staple NAFPs were also collected and calculated.ResultsA total of 174 Staple NAFPs were evaluated through systematic review, resulting in a total of 5302 peer-reviewed articles searched. Our findings show that most NAFPs are understudied and are more commonly seen by the agricultural community as weeds. However, there are a few that have current scientific interest in their value as a potential crop.DiscussionWe discuss the 24 most researched NAFPs and their nutritional content. We also discuss potential actions, protocols, and ethical issues regarding future steps in using NAFPs to increase agrobiodiversity and food resilience in the United States through more resilient agroforestry systems.

Making Sense of Change Through Simulation: Organizational Futures at Play

ABSTRACT Simulation can be a powerful vehicle for prospective sensemaking, especially in organizational change processes where actors’ ability to engage with possible futures is essential. Yet, the way that actors enact different potential futures together via simulation has not been fully explored nor investigated across different contexts. We report on a qualitative study of how healthcare staff in an emergency department (ED) made sense of a planned change process via a simulation tool to explore how moving into a new building might impact their work. We observed simulation sessions and interviewed managers and staff. Using sensemaking theory, we analyse how actors engaged in iterations of different forms of prospective sensemaking together, both in the simulated organizational change and of the organizational change process itself. We found that the way actors used their bodies and the simulation tool to experience potential changes in work environment and work processes elicited emotions such as worry and excitement and deliberations about consequences and potential actions. Our study highlights the interwoven embodied, material and emotional elements of prospective sensemaking: through simulation, we experience and feel the possible futures that can arise from change. MAD statement This article demonstrates how simulation tools can facilitate sensemaking of organizational change in and between individuals. It shows how simulations of work in future physical surroundings can elicit strong emotions such as worry and hope for the imagined futures. The findings shed light on how people, who are trying to explore what organizational change might mean for them and their work, relate to desired and undesired futures through their bodies and physical surroundings. Such prospective sensemaking is a significant driver of organizational change. Therefore, understanding the embodied, material and emotional aspects underpinning such processes is important for both scholarship and practice.

Insulin secretory actions of ethanolic extract of Acacia arabica bark in high fat-fed diet-induced obese Type 2 diabetic rats.

Acacia arabica commonly known as 'babul' has been widely used for the treatment of numerous diseases, including diabetes due to their potential pharmacological actions. The aim of the present study was to investigate the insulinotropic and antidiabetic properties of ethanol extract of Acacia arabica (EEAA) bark through in vitro and in vivo studies in high fat-fed (HFF) rats. EEAA at 40-5000 µg/ml significantly increased (P<0.05-0.001) insulin secretion with 5.6 and 16.7 mM glucose, respectively, from clonal pancreatic BRIN BD11 β-cells. Similarly, EEAA at 10-40 µg/ml demonstrated a substantial (P<0.05-0.001) insulin secretory effect with 16.7 mM glucose from isolated mouse islets, with a magnitude comparable to 1 µM glucagon-like peptide-1 (GLP-1). Diazoxide, verapamil, and calcium-free conditions decreased insulin secretion by 25-26%. The insulin secretory effect was further potentiated (P<0.05-0.01) with 200 µM isobutylmethylxanthine (IBMX; 1.5-fold), 200 µM tolbutamide (1.4-fold), and 30 mM KCl (1.4-fold). EEAA at 40 µg/ml, induced membrane depolarization and elevated intracellular Ca2+ as well as increased (P<0.05-0.001) glucose uptake in 3T3L1 cells and inhibited starch digestion, glucose diffusion, dipeptidyl peptidase-IV (DPP-IV) enzyme activity, and protein glycation by 15-38%, 11-29%, 15-64%, and 21-38% (P<0.05, 0.001), respectively. In HFF rats, EEAA (250 mg/5 ml/kg) improved glucose tolerance, plasma insulin, and GLP-1 levels, and lowered DPP-IV enzyme activity. Phytochemical screening of EEAA revealed the presence of flavonoids, tannins and anthraquinone. These naturally occurring phytoconstituents may contribute to the potential antidiabetic actions of EEAA. Thus, our finding suggests that EEAA, as a good source of antidiabetic constituents, would be beneficial for Type 2 diabetes patients.

Potential Role of Protein Kinase FAM20C on the Brain in Raine Syndrome, an In Silico Analysis.

FAM20C (family with sequence similarity 20, member C) is a serine/threonine-specific protein kinase that is ubiquitously expressed and mainly associated with biomineralization and phosphatemia regulation. It is mostly known due to pathogenic variants causing its deficiency, which results in Raine syndrome (RNS), a sclerosing bone dysplasia with hypophosphatemia. The phenotype is recognized by the skeletal features, which are related to hypophosphorylation of different FAM20C bone-target proteins. However, FAM20C has many targets, including brain proteins and the cerebrospinal fluid phosphoproteome. Individuals with RNS can have developmental delay, intellectual disability, seizures, and structural brain defects, but little is known about FAM20C brain-target-protein dysregulation or about a potential pathogenesis associated with neurologic features. In order to identify the potential FAM20C actions on the brain, an in silico analysis was conducted. Structural and functional defects reported in RNS were described; FAM20C targets and interactors were identified, including their brain expression. Gene ontology of molecular processes, function, and components was completed for these targets, as well as for potential involved signaling pathways and diseases. The BioGRID and Human Protein Atlas databases, the Gorilla tool, and the PANTHER and DisGeNET databases were used. Results show that genes with high expression in the brain are involved in cholesterol and lipoprotein processes, plus axo-dendritic transport and the neuron part. These results could highlight some proteins involved in the neurologic pathogenesis of RNS.