Potential Triggers Research Articles

A case report of Hennessey-induced urticaria in a healthcare centre in suburban Africa

This case report explores the unprecedented manifestation of generalised urticaria consistently affecting specific body surfaces in a 25-year-old female patient following Hennessy consumption. The patient's medical history aligns with existing literature implicating alcohol as a potential trigger for urticarial symptoms. While the pathogenesis of mast cell activation due to alcohol remains elusive, presented findings contribute to the growing body of knowledge. The case underscores the importance of recognising alcohol as a potential aetiological factor for urticaria. This unique presentation of generalised urticaria prompts clinicians to consider alcohol-induced urticaria in their differential diagnosis. This case report contributes to the evolving understanding of urticaria pathogenesis, urging continued exploration into the complex relationship between alcohol consumption and urticarial pathogenesis.

Seasonal Variation in Sudden Cardiac Death: Insights from a Large United Kingdom Registry

BackgroundSudden cardiac death (SCD) is relatively common and may occur in apparently healthy individuals. The role of seasonal variation as a risk factor for SCD is poorly understood. The aim of this study was to investigate whether SCD exhibits a predilection for specific seasons. MethodsWe reviewed a database of 4751 cases of SCD (mean age 38 ± 17 years) referred to our Center for Cardiac Pathology at St George’s University of London between 2000 and 2018. Clinical information was obtained from referring coroners who were asked to complete a detailed questionnaire. All cases underwent macroscopic and histological evaluation of the heart, by expert cardiac pathologists. ResultsSCD was more common during winter (26%) and rarer during summer (24%), p = 0.161. Significant seasonal variation was not observed among cases of sudden arrhythmic death syndrome (SADS, 2910 cases) in which the heart is structurally normal. In contrast, a significant difference in seasonal distribution among decedents exhibiting cardiac structural abnormalities at the post-mortem examination (n = 1841) was observed. In this subgroup, SCDs occurred more frequently during winter (27 %) compared to summer (22%) (p = 0.007). In cases diagnosed with a myocardial disease (n = 1399), SCD was most common during the winter (27%) and least common during the summer (22%) (p = 0.027). ConclusionsWhile SADS occurs throughout the year with no seasonal variation, SCD due to structural heart disease appears to be more common during the winter. Bio-meteorological factors may be potential triggers of SCD in individuals with an underlying structural cardiac abnormality.

Індикативні особливості тканинної та мікробної сенсибілізації в патогенезі генералізованого пародонтиту, афілійованого з ревматоїдним артритом

Relevance. A lot of research has been devoted to the pathogenesis of generalised periodontitis, but very often researchers do not take into account the fact that generalised periodontitis often occurs against the background of internal diseases of the body, which cause not only special manifestations of the course of generalised periodontitis, but also can affect the results of its prevention and treatment. In this sense, rheumatoid arthritis, which is accompanied by chronic systemic connective tissue damage, is noteworthy. Purpose: to determine the place and integrative features of tissue and microbial sensitisation in the pathogenesis of generalised periodontitis associated with rheumatoid arthritis. Material and methods of the study. Immunological studies were performed in 335 patients divided into 3 groups: Group 1 - the main group - consisted of 136 patients with GP in the setting of RA. Group 2 - control group - 71 patients with GP diseases without signs of RA. Group 3 - comparative - 128 people without GP disease, who had musculoskeletal diseases not related to RA and practically healthy people. The periodontal condition of patients was assessed in two groups using the following parameters: Silness-Loe index (PI), bleeding index (BOP), probing pocket depth (PPD), recession level (REC), clinical attachment level (CAL) and tooth loss. To determine microbial and tissue sensitisation, the leukocyte migration inhibition reaction was used with microbial antigens of streptococci and staphylococci, and tissue antigens (bone and synovial). All the data obtained were processed by the mathematical method of variation statistics. Results of the study. In the majority of patients with GP affiliated with RA, a pronounced sensitisation to streptococcal antigen was detected, which in the chronic course of GP was 70.3±4.3%. The acute course in this group was accompanied by a high level of sensitisation in a slightly lower percentage of patients in this group and amounted to 62.5±7.0%. In the control group, the frequency of sensitised individuals to streptococcal antigen was significantly lower and amounted to 37.5±8.9 in the chronic course and 44.0±6.1 in the acute course. In practically healthy people without pathology of internal organs, musculoskeletal system and without GP disease, this indicator was only 26.0±8.0. Conclusion. The presence of microbial and tissue sensitisation in patients with GP and RA indicates that similar and cross antigens of streptococcus and staphylococcus microorganisms with connective tissue are a potential trigger for the development of both GP and RA, which is the reason to consider GP and RA as comorbid diseases with similar pathogenetic mechanisms of development. Key words: generalised periodontitis, periodontal condition, rheumatoid arthritis, sensitisation, antigen.

Management of hereditary angioedema attacks by patients on long-term prophylaxis versus on-demand therapy only.

Despite the use of long-term prophylaxis (LTP) for hereditary angioedema (HAE), the risk of having an attack remains and patients with HAE and on LTP may still experience attacks that can be life threatening. However, the behavioralpatterns and perspectives surrounding HAE attack management by patients on LTP are not fully understood. This survey aimed to better understand and compare the behavioral patterns and perspectives, including attitudesand perceptions associated with on-demand treatment among patients on LTP versus those using on-demand therapy only. People living with HAE were recruited by the US Hereditary Angioedema Association to complete a 20-minute online survey between September 6 and October 19, 2022. Participants were stratified by treatment (50% using LTP [+ondemand therapy], 50% on-demand therapy only). Respondents included 107 patients with HAE (mean age, 41 years [range, 16-83 years]). Patients using LTP reported treating a mean +/- standard deviation 84.8% +/- 23.8% of their HAE attacks compared with a mean +/- standard deviation75.6% +/- 27.5% for patients with on-demand only treatment. Similar percentages of patients on LTP versus patients on-demand only reported always carrying on-demand treatment when away from home (35% versus 38%) and modifying their daily lives to minimize the occurrence of HAE attacks, which included avoiding potential triggers (42.9% versus 45.5%). Although patients on LTP treat a higher percentage of their attacks compared with patients with on-demand only treatment, both groups reported similar behaviors in terms of carrying on-demand treatment when away from home and modifying their daily lives to minimize the occurrence of HAE attacks. These findings highlight the importance of understanding patient perspectives and behaviors in the management of HAE.

Understanding the nature and impact of cognitive fluctuations and sleep disturbances in dementia with Lewy bodies: A qualitative caregiver study.

Dementia with Lewy bodies is characterised by rapid fluctuations in attention, which are known as "cognitive fluctuations." Despite the fact that cognitive fluctuations are considered to be a core dementia with Lewy bodies symptom, they are very difficult to define and measure using existing quantitative subjective measurement tools, which are typically completed by caregivers. Cognitive fluctuations are also likely to be influenced by various aspects of sleep, but this is as yet unexplored. The primary aim of this qualitative study was to investigate the phenomenology of cognitive fluctuations in dementia with Lewy bodies by understanding caregiver experiences. Seven caregivers of people with dementia with Lewy bodies completed one-to-one semistructured interviews, which were conducted by telephone. Caregivers were asked to describe the nature, frequency, duration and potential triggers of cognitive fluctuations that were experienced by the individual with dementia with Lewy bodies. Caregivers were also asked about the subjective sleep experience of the individual with dementia with Lewy bodies, and about their own sleep experiences. Interviews were audio recorded, transcribed verbatim and analysed using Thematic Analysis. Caregivers reported that there was a great deal of individual variation in the frequency, duration and severity of cognitive fluctuations. Patient sleep disturbances, including excessive daytime sleepiness, nocturnal awakenings, restless legs and sleep apnoea, were common. However, the impact of sleep alterations or experiences upon the fluctuations was reported to be less clear. Caregivers also reported that their own sleep was negatively affected, potentially due to actively listening for overnight events and behaviours. Qualitatively, caregivers report that dementia with Lewy bodies cognitive fluctuations show large individual variations in terms of their frequency, duration and severity, but that subjectively, sleep may not consistently influence this symptom. Specific, caregiver-focussed interventions are likely to be necessary to maintain good sleep health in dementia with Lewy bodies caregivers.

Stress and the domestic cat: have humans accidentally created an animal mimic of neurodegeneration?

Many neurodegenerative diseases (NDD) appear to share commonality of origin, chronic ER stress. The endoplasmic reticulum (ER) is a dynamic organelle, functioning as a major site of protein synthesis and protein posttranslational modifications, required for proper folding. ER stress can occur because of external stimuli, such as oxidative stress or neuroinflammatory cytokines, creating the ER luminal environment permissive for the accumulation of aggregated and misfolded proteins. Unresolvable ER stress upregulates a highly conserved pathway, the unfolded protein response (UPR). Maladaptive chronic activation of UPR components leads to apoptotic neuronal death. In addition to other factors, physiological responses to stressors are emerging as a significant risk factor in the etiology and pathogenesis of NDD. Owned cats share a common environment with people, being exposed to many of the same stressors as people and additional pressures due to their "quasi" domesticated status. Feline Cognitive Dysfunction Syndrome (fCDS) presents many of the same disease hallmarks as human NDD. The prevalence of fCDS is rapidly increasing as more people welcome cats as companions. Barely recognized 20 years ago, veterinarians and scientists are in infancy stages in understanding what is a very complex disease. This review will describe how cats may represent an unexplored animal mimetic phenotype for human NDD with stressors as potential triggering mechanisms. We will consider how multiple variations of stressful events over the short-life span of a cat could affect neuronal loss or glial dysfunction and ultimately tip the balance towards dementia.

Gradient myopic defocus causes scleral tissue reinforcement and structural scleral remodelling

Aims/Purpose: To determine histological effects of lens induced refractive change on scleral remodelling in chicks.Methods: 18 Ross‐Ross chicks were raised for 14 days on a 14 hr light/10 hr dark cycle. 6 chicks were allowed to develop normally. 6 chicks wore conventional ‐10D lenses for the full 14 days. 6 chicks wore conventional ‐10D lenses for the first 7 days and myopia progression control (MPC) lenses or the next 7 days. MPC lenses had a central power of ‐10D and a gradient power rise at pupil edge (+ 2.75D). Birds were euthanized after 14 days and eyes were routinely processed for histopathological evaluation. Whole mount H&E‐stained tissue sections were microscopically analysed using bright field microscopy.Results: All lens treated birds developed significant myopia as expected Total scleral thickness was significantly reduced in the group wearing conventional ‐10 lenses (p < 0.05), but remained comparable to the normal control group for the MPC lenses treated birds. New appositional growth of the cartilaginous sclera was observed in all MPC lenses treated eyes and only in those eyes. The thickness of the cartilaginous component of the sclera was 135 ± 6, 153 ± 5, 125 ± 8 μm for conventional myopic, MPC lenses treated, and control birds respectively. There was a significant increase in the cartilaginous scleral thickness in the MPC lenses treated birds compared to the other two groups (p < 0.03), but not between the conventional ‐10D lens treated and control birds (p > 0.05).Conclusions: It is possible to induce appositional growth in hyaline cartilage in the chick sclera. In our study, this has only been achieved by using MPC lenses to reverse previously induced experimental myopia with conventional minus lenses. Our finding suggests that gradient decrease in peripheral lens power and the resulting differential level of defocus it causes could be a potential trigger of scleral reinforcement through stimulation of cartilage growth in the chick sclera.

Extended ArchiMate Metamodel with a context-awareness layer for a dynamic Enterprise architecture model

Nowadays, in a turbulent environment, enterprise must be proactive and even predictive to survive in front of the plenty natures of dynamics. Achieving the desired proactivity and predictability, supposes that the enterprise works in advance on its internal transformation plans, but also develops an awareness to its context, to intercept, analyze and simulate any potential trigger of change that could affect its stability or more precisely its state of equilibrium. In this work, the concept of enterprise architecture is considered as a tool for establishing alignment between business, strategy, and IT. This paper is a continuation to previous works seeking for a dynamic model of enterprise architecture, able to respond in an autonomic manner to the turbulent environment. The self-adaptiveness was highlighted basically using the well-known loop, monitor, analyze, plan, execute and Knowledge. The use of Case-Based Reasoning was suggested to store a collection of problems and their resolutions, then using algorithms of similarity and adaptation to suggest the problem’s best fit solution. To make the reasoning mechanism and similarity process as reliable as possible, it was important to maximize experiences and expand the knowledge base. For thus, the proposition was to share knowledge bases. In this paper, the context awareness is considered as second source to enrich the knowledge base and to stay vigilant and sensitive to triggers of change.

Tracheostomies for respiratory failure are associated with a high inpatient mortality: a potential trigger to reconsider goals of care

IntroductionAcute care surgeons are frequently consulted for tracheostomy placement in the intensive care unit (ICU). Tracheostomy may facilitate ventilator weaning and improve physical comfort. Short-term outcomes after tracheostomy are not...

Challenges Encountered during Anaesthetic Management of a Patient with Congenital Methaemoglobinemia Posted for Laproscopic Inguinal Hernia Repair: A Case Report

Methaemoglobinemia is a rarely encountered haematological condition that can be congenital or acquired. Methaemoglobin is an abnormal type of haemoglobin that is oxidised and incapable of delivering oxygen to tissues. This can lead to cyanosis, hypoxia, acidosis, arrhythmias, and more, depending on the methaemoglobin concentration, and can be fatal. A thorough understanding of the disease process is essential to develop a suitable anaesthesia plan and prevent complications. Ensuring adequate tissue oxygenation, assessing oxygenation using appropriate monitoring tools, and avoiding trigger agents are the cornerstones of anaesthetic management. A co-oximeter is the gold standard for monitoring, as it detects and quantifies methaemoglobin levels. Methylene blue acts as an antidote, functioning as an oxidising agent that converts itself to leukomethylene blue, which reduces methaemoglobin back to haemoglobin. In the present case of a 60-year-old male, the authors present the anaesthetic management and challenges in a diagnosed case of congenital methaemoglobinemia undergoing laparoscopic inguinal hernia repair surgery. Methylene blue was administered prophylactically preoperatively. An arterial line was established before anaesthesia induction for close haemodynamic monitoring and quick blood gas and oxyhaemoglobin sampling, as a co-oximeter was not available. Adequate oxygenation during induction and emergence was ensured to prevent hypoxia, given the lower amount of normal haemoglobin in these patients. All potential trigger agents, such as nitrous oxide, local anaesthetics, nitrates, and metoclopramide, were avoided. The patient had an uneventful intraoperative and postoperative course and was discharged after one day.

Source area morphometry and high depletion rate of landslides may indicate their coseismic origin

Ancient coseismic landslides indicate prehistoric earthquakes and may also be a measure of their intensity. Their identification in the landscape remains, however, challenging. We used field geologic observations of source areas of recent rainfall-induced and earthquake-induced landslides to define a morphometric index that can distinguish between these two types of triggers. Morphometries of 129 landslides from tropical, subtropical and temperate zones developed in a variety of bedrock types were described by using the following parameters: i) depletion index (Id), i.e. the ratio between the length of the depleted part and the length of the source area; ii) relative slope height (Hrel) and iii) source area angle (φS), i.e. the angle between the top of the line connecting the scarp top with the toe of the source area and the horizontal plane. They were obtained using globally available digital elevation models and satellite images. Their combination into an Index of Potential Trigger (IPT) successfully distinguished between the two types of landslide triggers with an overall accuracy of 87%. The rainfall-induced landslides had a significantly lower average IPT value of 0.01 as compared with 0.37 for the coseismic landslides. The index of potential trigger may be a useful and readily implemented morphometric tool for preliminary identification of prehistoric coseismic landslides recorded in the current topography.

Legal Protection of Marks in the Perspective of Property Rights Law

The brand is the manufacturer's public persona, a barometer of the company's public standing, and a watershed moment in the company's overall business strategy. There's no getting around the fact that a product's brand serves as its identity; after all, it's what sets one firm apart from another. The protection of registered marks, however, is sometimes the source of intricate legal challenges that obscure the mark's true significance. The purpose of this research is to evaluate and analyze the legal protection of registered trademarks and to determine the reason of the termination of its protection using a normative juridical approach. The research uncovered a number of potential triggers for a brand's registration to be revoked, such as the end of the brand's validity period, a request for revocation by the brand's owner, ministerial initiative based on the recommendation of the brand appeal Commission, or a lawsuit filed by a third party. Once the trademark is registered, it is protected for a certain length of time that may be extended. Legal action, criminal prosecution, and administrative measures like trademark cancellation or registration rejection all serve as deterrents. Defending corporate identities through trademarks is crucial in today's period of intense global competition. This study delves deeply into the value of brands to manufacturers and the legal hurdles that must be overcome to ensure a brand's long-term viability in a competitive market. With this knowledge in hand, company stakeholders may take the necessary initiatives to establish a brand that will endure. Protecting your name and your ideas are essential.

A fox on the hunt: red fox (Vulpes vulpes) was able to subdue and kill an adult coypu (Myocastor coypus) in a protected site in south-eastern Bulgaria

In the present study, we report on a rare predatory behaviour in the red fox (Vulpes vulpes Linnaeus, 1758). In the early evening of 03.03.2023 we detected a red fox attacking and killing a coypu (Myocastor coypus Molina, 1782). We were able to document the event by the use of camera with tele-lens. The red fox was known to feed on smaller prey like insects, smaller rodents, lagomorphs, birds and others. Data on attacks on large and potentially dangerous prey are rather scarce and we discuss on the potential trigger for that predatory behaviour.

Artificial Intelligence and evolving issues under US copyright and patent law

The proliferation of AI tools in the arts, commercial design industries, and other endeavours has raised core questions regarding who or what actually supplied the alleged creative or inventive elements, if any, to the AI system’s output. In both US copyright and patent law the question focuses on a case-by-case analysis as to how much of the final product evidences human ‘authorship’ or invention. Also, creativity as well as infringement, can be located in various phases of the AI system’s creation, ingestion of training materials, management, and operation – including its output, whether affected prior to the output or after it. Issues such as liability for selecting ingestion materials or target data, as well as the potential inadvertent triggering of patent law’s bar date through use of specific AI systems, have also come to the forefront of AI’s potential to secure, forfeit, or impact claimed proprietary rights in AI-assisted creative and inventive activities. Several alternative intellectual property and unfair competition approaches that can supplement or supplant copyright and patent law principles also come into play as users of AI seek to protect the products of their efforts.

More than meat? Livestock farmers’ views on opportunities to produce for plant-based diets

Promoting plant-based diets as a response to climate crisis has clear implications for producers of animal derived foods, but surprisingly little research considers their perspectives on this. Our exploration focused on farming strongly associated with meat production in Wales, UK. Mindful of polarised debates around plant-based diets, we considered dietary transition as an opportunity to produce for new markets. The first aim was to identify whether transition towards plant-based diets might trigger transformation of livestock agriculture. Findings indicate a potential trigger event once livestock farmers are certain that consumer trends and climate mitigation require change. Livestock farmers who regard their meat as climate-friendly might resist transitions felt to unfairly disadvantage them. We then considered livestock farmers’ likely capacity to produce plant crops, and how this transformational capacity might be enhanced. Participants highlighted forms of financial and environmental inflexibility, plus social norms regarding “good” Welsh farmers, combining to make transformation risky. Transformational capacity might be enhanced through levering occupational and place attachments by portraying plant crops as a revival of historic practices from traditional farming landscapes. Improved linking capacity will also be beneficial, as producing for new markets requires connections to new supply chains, and learning across divisions within rural communities. We present these preliminary insights to livestock farmers’ attitudes and transformational capacity to inform future research with them to advance just agricultural transitions. Our study indicates potential to avoid confrontational discussion of dietary transition and we hope that others will pursue its focus on opportunities for farmers.

Successful caudal vena cava and pulmonary vein isolation in healthy horses using 3D electro-anatomical mapping and a contact force-guided ablation system.

Recently, treatment of equine atrial tachycardia by three-dimensional electro-anatomical mapping (3D EAM) and radiofrequency catheter ablation (RFCA) has been described. Myocardial sleeves in the caudal vena cava and pulmonary veins are a potential trigger for initiation and perpetuation of atrial tachycardia and atrial fibrillation in the horse. Isolation of these myocardial sleeves by RFCA may be an effective treatment for these arrhythmias. To describe the feasibility of 3D EAM and RFCA to isolate caudal vena cava and pulmonary veins in adult horses using 3D mapping and a contact force (CF)-guided ablation system. In vivo experiments. 3D EAM and RFCA was performed in five horses without cardiovascular disease under general anaesthesia, using the CF-guided system CARTO®3. Point-by-point RFCA aimed for isolation of caudal vena cava and pulmonary veins. Radiofrequency energy was delivered in power-controlled mode with a target power of 45 W, CF between 10 and 15 g and 30 mL/min irrigation rate, until an ablation-index of 450-500 was reached. In the right atrium, myocardial sleeves of the caudal vena cava were isolated (n = 5). In the left atrium, isolation of ostium II (n = 3), ostium III (n = 1) and ostium I, II and III en bloc (n = 1) was performed. Successful isolation was confirmed by entrance and exit block. Horses were euthanised at the end of the procedure, so long term effects such as potential reconnection of isolated veins could not be studied. This is the first description of 3D EAM and RFCA with CARTO®3 in horses, thereby showing the technical feasibility and successful caudal vena cava and pulmonary vein isolation. CF measurement allowed monitoring of catheter-tissue contact, resulting in efficient acute lesion creation as confirmed by entrance and exit block. This is a promising treatment for cardiac arrhythmias in horses.

Assessment of Novel Proteins Triggering Celiac Disease via Docking-Based Approach.

Human leukocyte antigens (HLAs) are pivotal in antigen processing, presenting to CD4+ T cells, and are linked to autoimmune disease susceptibility. In celiac disease, HLA-DQ2.5 and HLA-DQ8.1 bind gluten peptides on APCs, some recognized by CD4+ T cells, prompting inflammation and tissue damage. While extensively studied experimentally, these alleles lack comprehensive in silico analysis. To explore peptide-HLA preferences, we used molecular docking on peptide libraries, deriving quantitative matrices (QMs) for evaluating amino acids at nine-residue peptide binding cores. Our findings tie specific residue preferences to peptide backbone conformations. Validating QMs on known binders and non-binders showed strong predictive power (89-94% accuracy). These QMs excel in screening protein libraries, even whole proteomes, notably reducing time and costs for celiac disease risk assessment in novel proteins. This computational approach aligns with European Food Safety Authority guidance, promising efficient screening for potential celiac disease triggers.

Reported food-related symptoms and food allergen sensitization in a selected adult population in Hyderabad, India: A hospital-based survey

BackgroundResearch on reported food-related triggers of atopic disease in South Asian adults is lacking despite the region's large population, despite the global significance of allergic diseases. ObjectivesThe study aimed to identify prevalent local food items and assess allergic sensitization rates to potential trigger foods for atopic diseases via skin prick tests (SPT) and specific IgE (sIgE) testing. MethodsThe study began with a pilot survey (N=100; recruited from four hospitals in Hyderabad, focusing on foods perceived to relate to asthma, allergic rhinitis, atopic dermatitis, urticaria, and gastrointestinal allergic symptoms. Subsequently, a main study evaluated 2010 participants, of which 1754 individuals diagnosed with an aforementioned atopic disease reported allergic symptoms related to any of 77 foods identified in the pilot study. Ultimately, 1622 patients who consented to SPT and sIgE testing and reported at least one food item triggering allergic diseases were included in the final analysis. ResultsAmong 1622 patients (average age: 42.6±12.9 years; 55.5% male), asthma was the most common diagnosed atopic disease (26.4%), with itching and rashes as the frequently reported symptoms (22.7%). Notably, 94.9% of patients had total serum IgE >144 kU/L. Chickpea, cabbage, eggplant, walnut, cumin, and betel leaf were the most commonly reported trigger foods. ConclusionIn this sample of South Indian adults diagnosed with allergic disease, reported food triggers were most commonly local dietary staples, while reported reactions to priority allergens like peanut and sesame were conspicuously absent. Observed concordance between patient-reported food triggers and sensitization to reported food triggers was low, highlighting the need for improved clinical evaluation of suspected triggers.

Evaluation of Dermatological and Neurological Aspects of the Relationship between Rosacea and Headaches.

This study aimed to investigate the relationship between rosacea and headaches, focusing on different subtypes, as well as the associated clinical features and triggering factors. In this prospective study, 300 patients diagnosed with rosacea and 320 control subjects without rosacea or any connected mast cell activation illness were included. Patients with rosacea were assessed by a dermatologist according to the 2019 updated rosacea classification (ROSCO panel). Accordingly, patients were classified based on their predominant rosacea subtype as follows: erythematotelangiectatic (ETR), papulopustular (PPR), or phymatous (RhR). Patients experiencing headaches were assessed using the International Headache Classification. Headaches were categorized as migraine, tension-type headaches (TTHs), secondary types (STHs), and cluster-type headaches (CTHs). The ratio of headache was 30.3% in the rosacea group, which did not show a significant difference compared to the control group (30.3% vs. 25.0%, p = 0.138). In 81.3% of rosacea patients with headaches, headache onset occurred after the diagnosis of rosacea. The rate of patients with headaches was higher in the ETR group compared to the PPR and RhR groups (35.2% vs. 16.2% vs. 23.1%, p = 0.007, respectively). In terms of headache subtypes, the rates of patients with migraine and STHs were higher in the ETR group compared to the PPR and RhR groups, while the rate of patients with TTHs was higher in the RhR group. A positive correlation was found between rosacea severity and migraine severity (r = 0.284, p < 0.05). Among the triggering factors for rosacea, only sunlight was found to be associated with headaches. Lower age, female gender, and moderate to severe rosacea severity were identified as independent factors increasing the likelihood of headaches. A significant portion of rosacea patients experience headaches. Particularly, different subtypes of rosacea may be associated with various types of headaches. This study, highlighting the connection between migraine and ETR, is a pioneering work that demonstrates common pathogenic mechanisms and potential triggers.

A landslide dating framework using a combination of Sentinel-1 SAR and -2 optical imagery

Landslides are mass movements of rock or soil down a slope, which may cause economic loss, damage to natural resources and frequent fatalities. To support risk management, landslide dating methods can provide useful knowledge about the date of the landslide and the frequency of occurrences, and thus potential triggers. Remote sensing techniques provide opportunities for landslide dating and are especially valuable in remote areas. However, the use of optical remote sensing is frequently hampered by cloud cover, decreasing the success rate and accuracy of dating. Here, we propose a landslide dating framework that combines the advantages of optical and SAR remote sensing satellites, because optical monitoring provides spectral changes on the ground and microwave observations provide information on surface changes due to loss of coherence. Our method combines Sentinel-1 and -2 satellite data, and is designed for cases wherein the landslide causes vegetation decrease and terrain deformation resulting in changing Normalized Difference Vegetation Index (NDVI) and SAR backscatter values. This landslide dating framework was tested and evaluated against 60 published landslides across the world. We show that the mean accuracy of landslide dating reaches 23 days when using combined Sentinel-1 and -2 imagery, which is a pronounced improvement compared to using only optical Sentinel-2 images resulting in an accuracy of 51 days. This study highlights that a combination of optical and SAR remote sensing monitoring is a promising technique for dating landslides, especially in remote areas where monitoring equipment is limited or which are frequently covered by clouds. Our method contributes to identifying failure mechanism by providing reliable date ranges of landslide occurrence, assessing landslide hazard and constructing landslide early warning systems.