Potential Role Research Articles

Soluble adhesion molecules in serum and peritoneal fluid areassociated with pelvic pain in endometriosis.

To investigate the association between soluble adhesion molecules (sE-cadherin, sE-selectin, sICAM-1, sVCAM-1) in serum and peritoneal fluid and pelvic pain in infertile women with endometriosis. This observational study included 86 infertile women undergoing diagnostic laparoscopy, 43 of whom were diagnosed with endometriosis. Pain intensity was evaluated using the visual analog scale (VAS). Levels of soluble adhesion molecules in serum and peritoneal fluid were quantified using ELISA. Statistical analysis included the Mann-Whitney U test for group comparisons, Spearman's rank correlation for associations with VAS scores, and receiver operating characteristic (ROC) curve analysis for diagnostic performance. Serum sE-selectin levels were significantly higher in women with pelvic pain (P = 0.022) and correlated with VAS scores (r = 0.271, P = 0.012). Peritoneal sE-selectin and sICAM-1 levels were elevated in women with pelvic pain (P = 0.044 and P = 0.029, respectively) and showed positive correlations with VAS scores (r = 0.246, P = 0.022 and r = 0.310, P = 0.004, respectively). Comparing endometriosis and control groups, peritoneal sE-selectin and sICAM-1 levels were significantly higher in endometriosis cases with pelvic pain (P = 0.003 and P < 0.001, respectively). ROC analysis revealed the potential diagnostic value of serum sE-selectin (AUC = 0.698, P = 0.002), serum sICAM-1 (AUC = 0.721, P < 0.001), and serum sVCAM-1 (AUC = 0.750, P < 0.001) in distinguishing endometriosis from non-endometriosis cases. Elevated levels of sE-selectin and sICAM-1 in serum and peritoneal fluid are associated with pelvic pain in women with endometriosis, suggesting their role in pain pathogenesis and potential as biomarkers for pain severity and disease diagnosis. Further research is warranted to explore the underlying mechanisms and validate these findings in larger cohorts.

The hex1 gene of Trichoderma simmonsii is involved in stress responses, biocontrol potential and wheat plant growth

Woronin bodies are unique organelles in Pezizomycotina fungi that allow hyphae compartmentalization and prevent cytoplasmatic bleeding after mechanical injury. Several studies have related the peroxisomal protein HEX1, the major component of Woronin bodies with other biological processes such as hyphal growth, osmotic stress tolerance and pathogenicity. Trichoderma spp. are plant-beneficial multipurpose biological control agents, and proteomic and transcriptomic studies have shown that HEX1 and its corresponding gene are overrepresented when grown in the presence of fungal cell walls and plant polymers. To further investigate the involvement of hex1 in Trichoderma biology, we generated hex1 deletion transformants using the wheat endophytic strain T. simmonsii T137 as host. Results confirmed that hex1 gene is involved in the prevention of cytoplasmatic bleeding, and also has a role in fungal growth and biocontrol potential against phytopathogenic fungi and oomycetes. The involvement of hex1 in the fungal response to osmotic and oxidative stresses is conditioned by the type of stress and by the nutrient richness of the culture medium. The hex1 deletion also affected the interaction with wheat, but did not affect the plant protective effect of T137 against water stress. Overall, this study shows the implication of HEX1 in a wide range of biological processes necessary for T. simmonsii to deploy its abilities to be used as an agriculturally beneficial fungus.

Modifying functional groups of straw-based hydrogel provide soil N2O mitigation potential by complete denitrification

Farmed soil is considered to contribute more than 60% anthropogenic N2O emission which plays critical role in global warming potential. Straw-based hydrogels with abundant functional groups are commonly used in environmental and agronomic applications primarily as adsorbents. Those functional groups could mediate electron transfer in the process of adsorbates and might also regulate N2O emission. However, it was still unclear whether and how these functional groups affect the process. To address this knowledge gap, we employed spectral analysis and a robotized incubation system to determine mechanisms of different functional groups in influencing soil N2O. The results indicated that the straw-based hydrogel was capable of significantly reducing the emission of N2O in denitrification, and the electrochemical properties of the hydrogel had promoting effect of the microbial genetic potential for N2O reduction. Specifically, carboxymethyl (R-COO) and primary amine groups (R-NH2) promoted complete denitrification through electron supply. Furthermore, R-NH2 had a significant negative correlation with N2O emissions. To further verify the role of specific structures and functional groups in denitrification, we conducted an experiment using pure lignin as a template. This experiment resulted in an increase in R-NH2 content to 13.2% and a decrease in N2O emissions by 49.1% compared with straw hydrogel. These results prove the feasibility of straw-based hydrogel as a redox system to accelerate complete denitrification, and the electron-donating functional groups were significantly related to the reduction rate of N2O. Finally, based on these mechanisms, functional group targeted grafting technology was proposed to improve its ability to mitigate N2O emission reduction.

Inclusive Exploration of Harmonizing and Alternative Treatments for Hypothyroidism

: A clinical syndrome known as hypothyroidism occurs due to a shortage of thyroid hormone as a result of decreased production, abnormal distribution, or no action of thyroid hormones. The most typical clinical symptoms included are dry skin, hair loss, weight gain, painful-prolonged periods, infertility, balance problems, slow speech, bradycardia, hypothermia, fatigue, anxiety &amp; depression, joint pain, and indigestion. Basically, age, gender, the severity of the ailment, and a few other factors affect the various signs and symptoms of hypothyroidism. The limitations of allopathic modalities necessitate the investigation of alternative treatment options. Future healthcare initiatives for the poor world will increasingly depend on CAM approaches to these concerns because lifestyle, diet, obesity, lack of exercise, and stress are significant contributing factors to the development of hypothyroidism. This review's objective is to provide information on herbs as well as complementary and alternative medications which are grouped into five major domains: Biologically Based therapies, Manipulative body-based therapies, Mind body-based therapies, and the whole Medical system. These have traditionally been used to treat thyroid dysfunction. The distribution of diseases in emerging nations is altering as a result of globalization. Hence the existing and potential roles of CAM techniques in the general practice of medicine are illustrated in these approaches. Scientists are being compelled to consider traditional herbal medical treatments and CAM therapy in order to combat adverse medication occurrences, high treatment costs, and compliance problems thus described in this review paper.

Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions.

Dementia in neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB) is a progressive neurological condition affecting millions worldwide. The amphiphilic molecule GM2 gangliosides are abundant in the human brain and play important roles in neuronal development, intercellular recognition, myelin stabilization, and signal transduction. GM2 ganglioside's degradation requires hexosaminidase A (HexA), a heterodimer composed of an α subunit encoded by HEXA and a β subunit encoded by HEXB. The hydrolysis of GM2 also requires a non-enzymatic protein, the GM2 activator protein (GM2-AP), encoded by GM2A. Pathogenic mutations of HEXA, HEXB, and GM2A are responsible for autosomal recessive diseases known as GM2 gangliosidosis, caused by the excessive intralysosomal accumulation of GM2 gangliosides. In AD, PD and DLB, GM2 ganglioside accumulation is reported to facilitate Aβ and α-synuclein aggregation into toxic oligomers and plaques through activation of downstream signaling pathways, such as protein kinase C (PKC) and oxidative stress factors. This review explored the potential role of GM2 ganglioside alteration in toxic protein aggregations and its related signaling pathways leading to neurodegenerative diseases. Further review explored potential therapeutic approaches, which include synthetic and phytomolecules targeting GM2 ganglioside accumulation in the brain, holding a promise for providing new and effective management for dementia.

Premenstrual Syndrome: An Overview of the Review Analysis, and Potential Role of Herbal and Dietary Supplements

: A premenstrual syndrome is a group of regular physiological, mental, emotional, and behavioral symptoms that appear periodically in the luteal phase of the menstrual cycle, and they vanish quickly with the beginning of menstruation or a few days afterward. Thus, severe premenstrual syndrome (PMS) affects 5–8% of women; the majority of these individuals also match the factors for premenstrual dysphoric disorder (PMDD). Premenstrual syndrome typically includes physical problems like headache, tiredness, indigestion, insomnia, nausea, and breast tenderness as well as symptoms associated with emotions (mood swings, anxiousness, and aggressiveness). Although the true mechanism of PMS is unknown, a number of theories point to increased sensitivity to typical hormonal changes and imbalances in neurotransmitters. A multidisciplinary team using an integrative holistic approach in the direction of an individualized strategy gradually manages PMS. The first phase entails educating women about PMS, self-screening, herbs like St John’s Wort, chaste berry, saffron; ginkgo biloba; chamomile, evening primrose, turmeric and so on, various nutrition supplements as Vitamin B6; calcium; magnesium and lifestyle adjustments like dietary modifications; exercise; yoga; sleep hygiene. The second step involves implementing various relaxation therapies, cognitive behavioral therapy (CBT), stress reduction techniques, and acupuncture. The available treatment as various drugs like SSRIs; serotonergic antidepressants; anxiolytics and hormonal therapy that are used currently to treat PMS, exhibits unwanted side effects. Therefore, this issue and other similar gynecological conditions have been discussed and managed with herbal medicines and other natural solutions in this comprehensive piece of work.

When thinking about pain contributes to suffering: the example of pain catastrophizing

Abstract The extensive literature on the potent role negative thoughts about pain have on the experience of pain and pain-related suffering has documented associations with important neurobiological processes involved in amplifying nociceptive signals. We focus this review on pain catastrophizing (pCAT)— appraisals of pain as threatening, overwhelming, and unmanageable— and review the evidence that these thoughts are learned in childhood through experience and observation of others, particularly caretakers and parents. For children who have learned pCAT, repeated exposures to pain over time activate pCAT and likely contribute to further amplification of pain through changes in the neurobiological pain regulatory systems, which overlap with those regulating the stress response. We propose that repeated pain and stress exposures throughout childhood, adolescence, and into adulthood alter the neurobiology of pain via a repetitive positive feedback loop that increases risk for heightened pain sensitivity over time with repeated exposures. At some point, often precipitated by an acute episode of pain and possibly influenced by allostatic load, pCAT contributes to persistence of episodic or acute pain and exacerbates pain-related suffering. This developmental trajectory is not inevitable, as the impact of pCAT on pain and pain-related suffering can be influenced by various factors. We also present future directions for work in this area.

Alkaloids - An Important Aspect of Medicinal Plants in Pharmaceutical World: An Overview

Alkaloids are major important constituent among different chemical constituents. Alkaloids have obtained in lots of plants in different location of world. These constituents have been used for different types of medicinal purposes as well as for the treatment of different diseases. These materials have potent role in also maintaining the plant profile. Lots of major chemical groups fall under this category. Many plants like Ephedra, Pilocarpus, Belladonna, Vasaka, Datura, Vinca, Cinchona, Kurchi, Ashwagandha, etc are belonging to this constituent. Among those Cinchona, Vasaka, Vinca, Belladonna and so many plants are showing significant role for treating different health issues from ancient days to till now. The article objects that the important, classification, constituents as well as the distribution of alkaloids into large amount of plant profiles.

Do digitalization and green innovation limit carbon emissions? Evidences from BRICS economies

Rapidly evolving innovation and digitalization have captured the focus of policymakers and scholars regarding their potent role in influencing environmental quality. The present research analyzes the impact of these variables on the carbon emissions of Brazil, Russia, India, China, and South Africa economies from 1990 to 2021. This research also explores the impact of economic growth, quadratic green innovation, and green energy on carbon emissions. Using several panel diagnostic tests, this research validates heterogeneous slopes, the presence of cross-sectional dependence, and significant cointegration. Due to the mixed integration order, this research uses a cross-sectional augmented autoregressive distributed lag model, and the results show that economic expansion and green innovation are significant drivers of emissions in both the short and long run. However, digitalization, quadratic green innovation, environmental policy stringency, and green energy are significant in improving environmental quality and sustainability. The long-term results are tested by employing a series of parametric and nonparametric regressions. This research recommends further investment in environmental research and development, digital technologies, green innovation, and the strengthening of environmental policies to attain sustainable development.

Reassessing Early Childhood Literature for Quality Education and Gender Equality in the Context Of SDGs

Objective: The objective is to study the gender stereotypes learnt knowingly or unknowingly by children through nursery rhymes and to highlight the problematic areas to revamp for providing quality education which focuses on a more gender equal society considering the Sustainable Development Goals. Theoratical Framework: We engage in the theory of social construction by Butler and the developmental theory of Vygotsky to propose that if the literature taught in childhood is rich and diverse the chances of developing gender sterotypes by individuals reduces to a great extent. Method: The focus of the study is the nursery rhymes taught at pre-schools and primary schools. Data was collected through interviews and questionnaire with teachers at various schools in Ahmedabad (a city in the state of Gujarat, India). The method of critical discourse analysis is used to analyse the rhymes and bring forth the implicit gender hegemony. Results &amp; Discussion: The analysis underscores the subtle yet potent role of language, especially nursery rhymes, in reinforcing traditional gender norms and expectations, thus influencing children's understanding of appropriate behaviours based on gender. The study highlights gender stereotypes, particularly about the interaction of one gender with the other, focusing on the depiction of dependency and power dynamics in relationships. It depicts women as dependent and men as dominant reflecting societal gender inequalities. Research implications: This study calls for a reassessment of nursery rhymes to promote diversity and positive values through quality education, urging educators to update content to align with modern views on gender equality. Originality/ Value: There has not been sufficient research done on nursery rhymes taught in schools with the aim of reducing/removing gender stereotypes aiming for quality education with the goal of achieving a gender fair society in the context of Sustainable Development Goals.

Long noncoding RNA DDX11-AS1 represses sorafenib-induced ferroptosis in hepatocellular carcinoma cells via Nrf2-Keap1 pathway

Sorafenib, a first-line therapeutic option for advanced hepatocellular carcinoma (HCC), faces a formidable challenge in the form of emerging resistance. Recently, the oncogene DDX11 antisense RNA 1 (DDX11-AS1) has been implicated in various cancers, including HCC. However, its role in sorafenib resistance remains unknown. Our findings reveal that DDX11-AS1 is upregulated in sorafenib-resistant HCC cells, contributing to their resistance by suppressing ferroptosis. Further investigation elucidated the mechanism by which DDX11-AS1 activates the antioxidant Nrf2-Keap1 pathway. By interacting with Nrf2 and hindering its association with Keap1, DDX11-AS1 enhances the stability and nuclear translocation of Nrf2. In summary, our study unveils the potent role of DDX11-AS1 as an enhancer of sorafenib resistance, inhibiting sorafenib-induced ferroptosis through the activation of the Nrf2-Keap1 pathway in HCC. These findings offer a promising therapeutic strategy to overcome resistance and effectively treat HCC.

Multiomics identification of ALDH9A1 as a crucial immunoregulatory molecule involved in calcific aortic valve disease

Mitochondrial dysfunction and immune cell infiltration play crucial yet incompletely understood roles in the pathogenesis of calcific aortic valve disease (CAVD). This study aimed to identify immune-related mitochondrial genes critical to the pathological process of CAVD using multiomics approaches. The CIBERSORT algorithm was employed to evaluate immune cell infiltration characteristics in CAVD patients. An integrative analysis combining weighted gene coexpression network analysis (WGCNA), machine learning, and summary data-based Mendelian randomization (SMR) was performed to identify key mitochondrial genes implicated in CAVD. Spearman’s rank correlation analysis was also performed to assess the relationships between key mitochondrial genes and infiltrating immune cells. Compared with those in normal aortic valve tissue, an increased proportion of M0 macrophages and resting memory CD4 T cells, along with a decreased proportion of plasma cells and activated dendritic cells, were observed in CAVD patients. Additionally, eight key mitochondrial genes associated with CAVD, including PDK4, LDHB, SLC25A36, ALDH9A1, ECHDC2, AUH, ALDH2, and BNIP3, were identified through the integration of WGCNA and machine learning methods. Subsequent SMR analysis, incorporating multiomics data, such as expression quantitative trait loci (eQTLs) and methylation quantitative trait loci (mQTLs), revealed a significant causal relationship between ALDH9A1 expression and a reduced risk of CAVD. Moreover, ALDH9A1 expression was inversely correlated with M0 macrophages and positively correlated with M2 macrophages. These findings suggest that increased ALDH9A1 expression is significantly associated with a reduced risk of CAVD and that it may exert its protective effects by modulating mitochondrial function and immune cell infiltration. Specifically, ALDH9A1 may contribute to the shift from M0 macrophages to anti-inflammatory M2 macrophages, potentially mitigating the pathological progression of CAVD. In conclusion, ALDH9A1 represents a promising molecular target for the diagnosis and treatment of CAVD. However, further validation through in vivo and n vitro studies is necessary to confirm its role in CAVD pathogenesis and therapeutic potential.

Social Control and Health Behaviors Among Individuals Living with Parkinson's Disease: A Pilot Study.

Positive health behaviors (e.g., exercise, healthy eating habits, good sleep hygiene, treatment adherence) are important in ensuring optimal symptom management and health outcomes among individuals living with Parkinson's disease (PD). While multiple factors may influence engagement in health behaviors, little is known about the occurrence of social control, or relationship partners' attempts to influence and regulate another's behavior, and its potential role in the adoption of health behaviors among individuals with PD. To better understand the types of social control attempts employed and begin to explore the association between social control attempts and behavioral responses (e.g., engage in the targeted health behavior, hide the behavior) to those attempts, survey data were drawn from a cross-sectional, pilot study of married/partnered Veterans diagnosed with idiopathic PD (n = 25). Participants completed self-reported measures of sociodemographics, physical and mental well-being, relationship functioning, and both the frequency of and behavioral responses to positive and negative social control attempts. Although the majority of individuals reported their partners engaged in positive social control attempts, half also reported negative attempts. Bivariate analyses revealed more frequent positive social control attempts from one's partner were related to both positive and negative behavioral responses, and negative social control attempts were related to negative behavioral responses. However, when adjusting for covariates, positive social control attempts were related to positive behavioral responses, while negative social exchanges with one's partner (e.g., general conflict), rather than exposure to negative social control attempts, were related to negative behavioral responses. Findings lend preliminary evidence of the relationship between social control and exchanges and health behavior that may inform future, adequately powered observational and intervention studies that target interpersonal processes and health behaviors among individuals living with PD and their relationship partners.

Voltage Gated Ion Channels and Sleep.

Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or localization, can lead to irregular neuronal excitability and synaptic communication, which may manifest as various behavioral abnormalities, including disrupted rest-activity cycles. Research has highlighted the significant impact of voltage gated ion channels on sleep parameters, influencing sleep latency, duration and waveforms. Furthermore, these ion channels have been implicated in the vulnerability to, and the pathogenesis of, several neurological and psychiatric disorders, including epilepsy, autism, schizophrenia, and Alzheimer's disease (AD). In this comprehensive review, we aim to provide a summary of the regulatory role of three predominant types of voltage-gated ion channels-calcium (Ca2+), sodium (Na+), and potassium (K+)-in sleep across species, from flies to mammals. We will also discuss the association of sleep disorders with various human diseases that may arise from the dysfunction of these ion channels, thereby underscoring the potential therapeutic benefits of targeting specific ion channel subtypes for sleep disturbance treatment.

Potential Neuroprotective Role of Neurotrophin in Traumatic Brain Injury.

Traumatic brain injury (TBI) is a major global health issue that affects millions of people every year. It is caused by any form of external force, resulting in temporary or permanent impairments in the brain. The pathophysiological process following TBI usually involves excitotoxicity, mitochondrial dysfunction, oxidative stress, inflammation, ischemia, and apoptotic cell death. It is challenging to find treatment for TBI due to its heterogeneous nature, and no therapeutic interventions have been approved thus far. Neurotrophins may represent an alternative approach for TBI treatment because they influence various functional activities in the brain. The present review highlights recent studies on neurotrophins shown to possess neuroprotective roles in TBI. Neurotrophins, specifically brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) have demonstrated reduced neuronal death, alleviated neuroinflammatory responses and improved neurological functions following TBI via their immunomodulatory, anti-inflammatory and antioxidant properties. Further studies are required to ensure the efficacy and safety of neurotrophins to be used as TBI treatment in clinical settings.

Natural Flavonoids as an Intervention for Hepatic Encephalopathy: Preclinical Evidence-based Review

Abstract: Hepatic encephalopathy (HE) is a serious neuropsychiatric disorder caused in patients with both; acute and chronic liver diseases, which consists of various complications ranging from cognitive impairment, disorientation, confusion, and coma. The available therapies mainly focus on decreasing ammonia levels either through increasing its elimination or decreasing its production, some medications may subside the duration and limit the consequences of HE, but there is no complete available treatment for HE-like manifestation. Thus, there is a need to explore new pharmacotherapy for the treatment and management of HE. Flavonoids are polyphenolic compounds easily found in vegetables, fruits, flowers, beverages, and plants based foods. In modern research, flavonoids have gained attention due to their broad pharmacological properties, like anti-oxidant, antiviral, anti-inflammatory, cardioprotective, cytoprotective, and neuroprotective activity. Several preclinical studies suggest that various flavonoids have a potential therapeutic role in a variety of metabolic- related neurological disorders, including HE. This review focuses on all pre-clinical reports that highlight the neuroprotective potential of natural flavonoids for the management of HE. Based on numerous pre-clinical studies and taking into account the therapeutic effects of natural flavonoids, the present study illustrates the cellular and molecular mechanisms responsible for the potential role of natural flavonoids as pharmacotherapy for the management and treatment of HE.

Sex-specific divergences in the types and timing of infiltrating immune cells during the intervertebral disc acute injury response and their associations with degeneration

ObjectiveInadequate repair of the intervertebral disc (IVD) contributes to low back pain. Infiltrating immune cells into damaged tissues are critical mediators of repair, yet little is known about the identities, roles, and temporal regulation following IVD injury. By analyzing transcripts of immune cell markers, histopathologic analysis, immunofluorescence, and flow cytometry, we aimed to define the temporal cascade of infiltrating immune cells and their associations with IVD degeneration. MethodCaudal IVDs from 12-week old C57BL/6 mice were injured and monitored for 42-days post injury. Transcriptional markers identifying myeloid, B, and T immune cells, and angiogenic factors were measured in the IVDs every 2-3 days. Histopathologic degeneration of the IVD was measured throughout. Flow cytometry and immunofluorescence was used to identify and localize cells including the B, T, NKT, monocytes, neutrophils, macrophages, and dendritic cells. ResultsThe injured IVD revealed distinct phases of inflammation and proliferation. Robust temporal oscillation in the myeloid and T cell transcripts was observed in females. Cd3+ T cells were more abundant in females than in males. The Cd3+Cd4-Cd8- T cells that dominate the female cascade contain rare γδ T cells. Injury-mediated degeneration was prevalent in both sexes but more severe in males. ConclusionsThis study defines the coordinated infiltration of immune cells in the IVD following injury. We report the discovery of γδ T cells in the female IVD and this was associated with less severe degeneration. γδ T cells have potent anti-inflammatory roles and may suppress degeneration following IVD injury.

When news is entertainment: explaining the persistence of misinformation through the information environment

ABSTRACT Why does misinformation persist despite its corrections? To address this issue, we propose the ‘news as entertainment’ framework, explaining how commercial considerations of the media industry shape news consumption. Using a strategic case study, we examine India's information environment through this paradigm. Guided by industry metrics, we reveal the interplay of competing social and economic interests in a context marked by high choice and political polarization. Within this framework, we examine misinformation correction in practice, highlighting its contextual underpinnings and the potent role of mainstream media. Finally, we discursively analyze how audience responses underscore their ties to specific news environments. The ‘news as entertainment’ framework exposes the disjunction between contextually shaped misinformation and correction methods, emphasizing how media contexts influence audience receptivity to facts or falsehoods. This insight informs our understanding of misinformation mechanisms, correction, and persistence with implications for addressing these challenges.

Products of allelopathic plants for organic weed management: Environmentally approach

Allelopathic substances from different crops may have synergistic effects and can be applied in the mixture. In the previous research, several crop plants have been identified as phytotoxic against various weeds like sorghum, brassica, and sunflower. However, the effect of their tank mixture with each other was never studied in cotton before. Furthermore, it was not sure before this study whether the allele chemicals present in these crops viz. sorghum, sunflower and brassica can have synergistic or additive effects when applied in combination. Herbicides account for 42% of global pesticides’ use. Therefore, recent emphases have been on biological weed control measures so as to reduce dependence on synthetic herbicides and finding alternative strategies for weed control in agro ecosystems. Allelopathy is one of such strategies that can be explored for biological weed control of cropping systems. The mimosine that occurs in Leucaena has the potential to be used as a bio-herbicide in weed management. Mimosine is the main allelochemicals in Leucaena and is responsible for the strong allelopathic activity of the plant. The allelopathic effects of L. leucocephala towards several agricultural crops and forest trees have been reported. Plant seedlings of various crops possess allelopathic potential or weed-suppressing activity, including cucumber (Cucumber sativa L.), oat (Avena spp.) and rice (Oryza sativa L.). The main barley allelochemicals are the alkaloids gramine and hordenine which play a significant role in barley allelopathic potential and its defense against weeds, insects, or pathogens. In particular, barley allelopathic extracts have the ability to reduce emergence and growth of serious weeds like winter wild oat (Avena sterilis L.), hood canary grass (Phalaris paradoxa L.), black grass (Alopecurus myosuroides Huds.), great brome (Bromus diandrus Roth.), and wild mustard (Sinapis arvensis L.). This growth reduction has been mainly attributed to lipid peroxidation. Tamarindus contains allelochemicals on roots, leaves, seeds and bark , however, its allelopathic potential has not yet been compared to that of other allelopathic species such as Parthenium. Citharexylum (Citharexylum spinosum L) is equally a tree, a tropical plant with numerous usages but also know to have some allelopathic potential. Flower extracts have proved to be extremely potent to lettuce seed germination and seedlings growth and are very little known regarding its leaves phytotoxity. Consequently, the current experiment will provide additional information regarding Citharexylum leave allelopathic potential. Sunflower (Helianthus annuus L.). In Asteraceae members including sunflower, the main allelochemicals are sesquiterpenes, especially heliannuoles, sesquiterpene lactones and bisnorse squiterpenes, in addition to triterpenes and flavonoids Its allelopathic effects have been tested on both other crops and weeds, in field conditions and in vitro bioassays. In recent years, the allelopathic potential of Cynara cardunculus L., an herbaceous perennial species belonging to the Mediterranean basin, was assessed on seed germination and seedling growth of some weeds and target crops. Allelochemicals responsible for C. cardunculus allelopathy are the sesquiterpene lactones cynaropicrin, deacylcynaropicrin, 11, 13-dihydro-deacylcynaropicrin, aguerin B, grosheimin, 11,13-dihydroxy-8-deoxygrosheimin and cy-naratriol, as well as polyphenols such as caffeoylquinic and dicaffeoylquinic acids, luteolin and apigenin derivatives. Around 800 species of plants produce biologically active substances, but only a few of them are used in agricultural practice. However, in recent years, there has been an increase in interest in allelopathy due to the effective use of allelochemicals in plant protection, such as bioherbicides, bio insecticides, biofungicides and growth regulators.

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs).

Macrophages are essential immune cells present in all tissues, and are vital for maintaining tissue homeostasis, immune surveillance, and immune responses. Considerable efforts have identified shared and tissue-specific gene programs for macrophages across organs during homeostasis. This information has dramatically enhanced our understanding of tissue-restricted macrophage programming and function. However, few studies have addressed the overlapping and tissue-specific responses of macrophage subsets following inflammatory responses. One subset of macrophages that has been observed across several studies, lipid-associated macrophages (LAMs), have gained interest due to their unique role in lipid metabolism and potential as a therapeutic target. LAMs have been associated with regulating disease outcomes in metabolically related disorders including atherosclerosis, obesity, and nonalcoholic fatty liver disease (NAFLD). In this study, we utilized single-cell RNA sequencing (scRNAseq) data to profile LAMs across multiple tissues and sterile inflammatory conditions in mice and humans. Integration of data from various disease models revealed that LAMs share a set of conserved transcriptional profiles, including Trem2 and Lpl, but also identified key sets of tissue-specific LAM gene programs. Importantly, the shared LAM markers were highly conserved with human LAM populations that also emerge in chronic inflammatory settings. Overall, this analysis provides a detailed transcriptional landscape of tissue-restricted and shared LAM gene programs and offers insights into their roles in metabolic and chronic inflammatory diseases. These data may help instruct appropriate targets for broad or tissue-restricted therapeutic interventions to modulate LAM populations in disease.