BackgroundPrevious studies have identified an increased risk of suicidal behaviors among individuals with asthma. ObjectiveWe evaluated the long-term risk and factors related to suicide in the adult population with asthma. MethodsThis study used the Korean National Health Insurance Service data. We investigated the risk of suicide concerning the presence or absence of asthma and potential risk factors for suicide among 3,914,041 adults ≥ 20 years of age. ResultsDuring a median follow-up of 12.3 years (interquartile range, 12.1–12.6 years), 1,383 (0.48%) individuals with asthma died by suicide. Individuals with asthma had an increased risk of suicide compared to controls (adjusted hazard ratio [aHR] = 1.26, 95% confidence interval [CI] = 1.19–1.33). Suicide risk was especially high in individuals with asthma phenotypes: hospitalization-prone (aHR = 1.61, 95% CI = 1.40–1.84), non-obese (aHR = 1.37, 95% CI = 1.27–1.64), and asthma-chronic obstructive pulmonary disease overlap (ACO) (aHR = 1.47, 95% CI = 1.22–1.76). Coexisting underweight status (aHR = 2.54, 95% CI = 2.05–3.16), mental health disorders (schizophrenia [aHR = 3.38, 95% CI = 2.28–5.02], depression [aHR = 3.24, 95% CI = 2.85–3.68], and anxiety disorder [aHR = 2.47, 95% CI = 2.00–3.05]), and cancers (aHR = 2.22, 95% CI = 1.73–2.84) further increased the suicide risk. ConclusionAsthma was associated with an increased risk of suicide, particularly in hospitalization-prone, non-obese, and ACO phenotypes. The risk was further increased when asthma coexisted with underweight status, mental health disorders, or cancers.
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