Potential Resilience Research Articles

Early life environmental enrichment yields resilience to selected behavioural and brain responses to 5-fluorouracil in mice.

Chemotherapy remains the primary treatment modality for multiple cancer types, but the cytotoxicity of chemotherapeutic drugs often leads to persistent psychological disturbances that undermine daily function. Minimizing such unwanted effects is challenging in the rehabilitation/prehabilitation of cancer survivors, hence the impetus to identify modifiable external factors capable of improving the recovery process. The importance of social stimulation has been demonstrated in a mouse model showing that grouped housing lowered the likelihood of developing mood disturbance following exposure to chemotherapeutic drugs compared with isolated housing. Social impoverishment thus constitutes a risk factor, and social enrichment may be protective. However, the potential benefits of conventional environmental enrichment that entails extensive sensory and physical stimulation have remained untested in mice. Using C57BL/6 mice, we investigated this research gap by introducing environmental enrichment from an early age (at weaning) to maximize its resilience potential and delaying exposure to the common chemotherapeutic drug, 5-fluorouracil (5-FU), until adulthood (10 weeks old), which comprised six cycles of injections at 40 mg/kg/day × 5 days per fortnight. Our results showed that enriched housing nullified the elevation in anxiety behaviour and proliferation of hippocampal microglial cells caused by chronic 5-FU exposure. Enriched housing also lowered hippocampal IL-17 expression, effectively buffered against the stimulated release of IL-17 by 5-FU. These data extended the potential benefits of social engagement and an active lifestyle in easing the burdens of chemotherapy. Notwithstanding, the negative impacts of 5-FU on hippocampal neurogenesis and musculoskeletal properties were only notable in the enriched mice, suggesting that while environmental enrichment can buffer against certain psychological side effects, the enhanced adaptive plasticity may also increase the susceptibility to specific antineoplastic effects of chemotherapy.

Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals.

Treatment options for viral infections are limited and viruses have proven adept at evolving resistance to many existing therapies, highlighting a significant vulnerability in our defenses. In response to this challenge, we explored the modulation of cellular RNA metabolic processes as an alternative paradigm to antiviral development. Previously, the small molecule 5342191 was identified as a potent inhibitor of HIV-1 replication by altering viral RNA accumulation at doses that minimally affect host gene expression. In this report, we document 5342191 as a potent inhibitor of adenovirus, coronavirus, and influenza replication. In each case, 5342191-mediated reduction in virus replication was associated with altered viral RNA accumulation and loss of viral structural protein expression. Interestingly, while resistant viruses were rapidly isolated for compounds targeting either virus-encoded proteases or polymerases, we have not yet isolated 5342191-resistant variants of coronavirus or influenza. As with HIV-1, 5342191's inhibition of coronaviruses and influenza is mediated through the activation of specific cell signaling networks, including GPCR and/or MAPK signaling pathways that ultimately affect SR kinase expression. Together, these studies highlight the therapeutic potential of compounds that target cellular processes essential for the replication of multiple viruses. Not only do these compounds hold promise as broad-spectrum antivirals, but they also offer the potential of greater resilience in combating viral infections.

Social Support as Resilience Factor in the Aftermath of October 7th Attack

A sharp increase in posttraumatic stress disorder (PTSD) symptoms has been detected in Israel following the terror attacks of October 7th 2023. To examine the role of potential resilience factors, we investigated the moderating effects of social support and coping strategies in the relationship between trauma exposure and severity of PTSD and emotional distress symptoms. Approximately 20 days following the terror attack, 415 Israeli adults were assessed for PTSD symptoms, general distress, extent of social support and coping strategies. The results indicated a significant moderating effect for perceived social support (B = −1.02, SE = 0.47, p = .031), indicating a significantly stronger association between trauma exposure and PTSD symptoms for individuals with low support (B = 5.22, SE = 0.91, p < .001), compared to for individuals with high support (B = 2.49, SE = 0.87, p = .004). This effect was significant for social support from a significant other and friends (B = −1.24, SE = 0.49, p = .011 and B = −0.86, SE = 0.42, p = .042, respectively), but not from family. Coping orientation to problems had no moderating effect on these associations. These findings underscore the importance of social support as a protective factor in the aftermath of collective trauma and sets the stage to consider this factor as a pivotal element in resilience-oriented interventions.

Longitudinal evaluation of the early auditory gamma-band response and its modulation by attention in first-episode psychosis.

Executive control over low-level information processing is impaired proximal to psychosis onset with evidence of recovery over the first year of illness. However, previous studies demonstrating diminished perceptual modulation via attention are complicated by simultaneously impaired perceptual responses. The present study examined the early auditory gamma-band response (EAGBR), a marker of early cortical processing that appears preserved in first-episode psychosis (FEP), and its modulation by attention in a longitudinal FEP sample. Magnetoencephalography was recorded from 25 FEP and 32 healthy controls (HC) during active and passive listening conditions in an auditory oddball task at baseline and follow-up (4-12 months) sessions. EAGBR inter-trial phase coherence (ITPC) and evoked power were measured from responses to standard tones. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). There was no group difference in EAGBR power or ITPC. While EAGBR ITPC increased with attention in HC, this modulation was impaired among FEP. Diminished EAGBR modulation in FEP persisted at longitudinal follow-up. However, among FEP, recovery of EAGBR modulation was associated with reduced PANSS negative scores. FEP exhibit impaired executive control over the flow of information at the earliest stages of sensory processing within auditory cortex. In contrast to previous work, this deficit was observed despite an intact measure of sensory processing, mitigating potential confounds. Recovery of sensory gain modulation over time was associated with reductions in negative symptoms, highlighting a source of potential resiliency against some of the most debilitating and treatment refractory symptoms in early psychosis.

Artificial Intelligence as a tool for enhancing Building Information Modeling (BIM)

Building Information Modeling (BIM) has revolutionized the Architecture, Engineering, and Construction (AEC) industry, transforming how building lifecycle data is managed and visualized. By consolidating physical and functional characteristics into a shared digital model, BIM facilitates collaboration, minimizes rework, and streamlines planning and execution. In sustainability, BIM supports "Green BIM" practices that reduce carbon footprints by enabling energy modeling and lifecycle analysis. However, despite these advances, BIM faces interoperability issues, largely due to proprietary software formats, leading to isolated data silos that impede efficient data exchange across platforms. The integration of Artificial Intelligence (AI) into BIM introduces groundbreaking solutions to these challenges. AI enhances BIM through automation of design validation, clash detection, and real-time data analysis, transforming BIM into an adaptive system capable of proactive decision-making. AI applications, including predictive maintenance, generative design, and real-time construction monitoring, promise higher safety standards, reduced errors, and improved lifecycle management. However, AI-enhanced BIM adoption is hampered by technical, ethical, and financial challenges, such as data quality, privacy concerns, and high implementation costs. Addressing these obstacles with standardized data protocols, workforce upskilling, and collaborative frameworks can maximize the potential of AI-driven BIM, advancing sustainability, efficiency, and resilience within the construction industry.

Venture Capital and Vulnerability: Navigating Natural Disasters and Investment Resilience

ABSTRACTThis study examines the impact of natural disasters on venture capital (VC) investment decisions. Using 47 catastrophic natural disasters occurred in the United States from 1990 to 2019, our empirical analysis reveals a significant reduction in VC investments in disaster zones. Additionally, natural disasters negatively influence VC exit strategies, reducing the likelihood and extending the time to successful exits via IPOs. However, we find that green VCs are more likely to invest in disaster‐affected areas, indicating potential resilience through green technological innovation. Our findings emphasize sustainability and disaster mitigation, and offer valuable insights for policymakers and investors amidst rising climate uncertainties.

Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.

Alzheimer's disease and related dementias (AD/ADRDs) pose a significant global public health challenge, underscored by the intricate interplay of genetic and environmental factors that differ across ancestries. To effectively implement equitable, personalized therapeutic interventions on a global scale, it is essential to identify disease-causing mutations and genetic risk and resilience factors across diverse ancestral backgrounds. Exploring genetic-phenotypic correlations across the globe enhances the generalizability of research findings, contributing to a more inclusive and universal understanding of disease. This study leveraged biobank-scale data to conduct the largest multi-ancestry whole-genome sequencing characterization of AD/ADRDs. We aimed to build a valuable catalog of potential disease-causing, genetic risk and resilience variants impacting the etiology of these conditions. We thoroughly characterized genetic variants from key genes associated with AD/ADRDs across 11 genetic ancestries, utilizing data from All of Us, UK Biobank, 100,000 Genomes Project, Alzheimer's Disease Sequencing Project, and the Accelerating Medicines Partnership in Parkinson's Disease, including a total of 25,001 cases and 93,542 controls. We prioritized 116 variants possibly linked to disease, including 18 known pathogenic and 98 novel variants. We detected previously described disease-causing variants among controls, leading us to question their pathogenicity. Notably, we showed a higher frequency of APOE ε4/ε4 carriers among individuals of African and African Admixed ancestry compared to other ancestries, confirming ancestry-driven modulation of APOE-associated AD/ADRDs. A thorough assessment of APOE revealed a disease-modifying effect conferred by the TOMM40:rs11556505, APOE:rs449647, 19q13.31:rs10423769, NOCT:rs13116075, CASS4:rs6024870, and LRRC37A:rs2732703 variants among APOE ε4 carriers across different ancestries. In summary, we compiled the most extensive catalog of established and novel genetic variants in known genes increasing risk or conferring resistance to AD/ADRDs across diverse ancestries, providing clinical insights into their genetic-phenotypic correlations. The findings from this investigation hold significant implications for potential clinical trials and therapeutic interventions on a global scale. Finally, we present an accessible and user-friendly platform for the AD/ADRDs research community to help inform and support basic, translational, and clinical research on these debilitating conditions (https://niacard.shinyapps.io/MAMBARD_browser/).

Resilience and hopelessness mediate the relationship between benevolent childhood experiences and life satisfaction: evidence from a cross-cultural study

BackgroundA growing body of literature focuses on the role of benevolent childhood experiences (BCEs) in predicting adulthood well-being, in addition to adverse childhood experiences (ACEs). However, cross-cultural differences are generally ignored in this endeavor. Hence, this study aimed to explore the role of BCEs in predicting life satisfaction, resilience, and hopelessness. We also examined the potential of resilience and the role of hopelessness in mediating the relationship between BCE and life satisfaction.MethodsA total of 850 university students from Turkey (n = 371), Portugal (n = 248), and India (n = 231), aged 17 to 58 years (M = 22.12, SD = 4.41), participated in the study. Participants completed an online protocol consisting of measures to assess BCEs, life satisfaction, resilience, and hopelessness.ResultsBCEs, hopelessness, and life satisfaction have significantly differed among the samples based on the country of residence. BCEs were positively correlated to resilience and life satisfaction and negatively to hopelessness. In the sequential mediation model, after controlling for country and sex, resilience and hopelessness sequentially mediated the relationship between BCEs and life satisfaction. BCEs were associated with life satisfaction, resilience, and hopelessness across countries and sexes. The model explains 42.8% of the variability.ConclusionDespite differences between countries, BCEs are important predictors of adult well-being in all three countries and should be monitored along with ACE. Further, resilience seems to have an important role in lowering the negative consequences of lower BCEs and feelings of hopelessness, pointing to the need to strengthen psychological resilience among adults.

Move past adversity or bite through it? Diet quality, physical activity, and sedentary behavior in relation to resilience.

Adverse life experiences are associated with an increased risk of mental disorders. The successful adaptation to adversity and maintenance or quick restoration of mental health despite adversity is referred to as resilience. Identifying factors that promote resilience can contribute to the prevention of mental disorders. Lifestyle behaviors, increasingly recognized for their impact on mental health, are discussed as potential resilience factors. Several studies found that healthy eating and physical activity (PA) are positively associated with resilience. However, most of these studies assessed resilience through questionnaires, which is unsatisfactory given that resilience research is moving toward conceptualizing resilience as the outcome of a dynamic process, which can only be assessed prospectively and longitudinally. The present study is the first to assess the relationship between diet quality, PA, sedentary behavior (SB), and resilience, captured prospectively and longitudinally in a sample of 145 individuals (75.17% female; Mage = 28.88, SDage = 7.80; MBMI = 24.11, SDBMI = 3.97). Resilience was assessed as the relationship between stressor exposure and mental health (i.e., the stressor reactivity score: higher scores indicate lower resilience and vice versa). Diet quality (i.e., the Healthy Eating Index) was assessed on the basis of app-based food records and 24-hr dietary recalls. PA and SB were objectively recorded through accelerometers. Regression analysis showed that neither diet quality nor PA and SB predicted resilience (ps > .30). Profound differences in the conceptualization and operationalization of resilience might explain the contrary findings. Prospective longitudinal studies are needed to replicate the findings of the present study. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Looking for the good in times of adversity: Examining the interplay of temperament and social schemas in shaping resilience in youth.

Resilience is a broad and dynamic concept that can be seen as being constituted by the combination of internal factors, for example, temperament profiles, and external factors, for example, social support. This paper aimed to identify temperament profiles in help-seeking youth exposed to adverse childhood experiences, and to investigate whether temperament (putative internal protective factor) interacts with social schemas (as proxy for the putative external protective factor social support) such that their combination is associated with (a) reduced mental health problems and (b) attenuated decrease in positive affect following daily life stressors. Self-report questionnaires were used to measure temperament, social schemas and mental health problems. The experience sampling method was used to assess stress and positive affect (i.e., stress-sensitivity as a potential daily life resilience mechanism). Temperament profiles were identified by latent profile analysis and regression analyses were used to examine (interaction) effects. In 138 subjects, three temperament profiles were identified, that is, a moderate, volatile and persevering profile, of which the latter was negatively associated with mental health problems. Neither mental health problems nor stress sensitivity were found to be affected by the interaction between temperament and social schemas. However, positive social schemas were found to be independently associated with reduced mental health problems (b = -4.41; p = <.001) and reduced stress sensitivity (b = .10, p = .044). Findings are relevant for both practice and research, and contribute to improving our understanding of putative protective factor in the development of mental ill-health, thereby further unravelling the construct of resilience.

The STAR collaborative nonsuicidal self-injury study: methods and sample description of the face-to-face sample

BackgroundNonsuicidal self-injury (NSSI) is highly prevalent in adolescents and young adults worldwide. It is linked to a broad variety of mental disorders and an increased suicide risk. Despite its high prevalence, research on the underlying mechanisms and on potential risk and resilience factors for maintaining or quitting NSSI remains scarce. This manuscript presents an overview of the “Self-injury: Treatment-Assessment-Recovery” (STAR) collaboration, which aimed to address these gaps.MethodsWe investigated the natural course of NSSI as well as its social, psychological, and neurobiological predictors (observational study; OS). OS data collection occurred at four timepoints (baseline [T0], 4 [post, T1], 12 [follow-up (FU), T2], and 18 [FU, T3] months after baseline) for the NSSI group, which was compared to a healthy control (HC) group at T0 only. Online self-report was used at all timepoints, while semi-structured interviews (face-to-face (f2f)) were conducted at T0 and T3. At T0 only, we conducted ecological momentary assessment and neurobiological investigations. Here, we present the general methodology and sample characteristics of the completed OS including the f2f subprojects, while other subprojects are not within the scope of this paper.Sample descriptionThe OS sample consists of 343 participants at T0 (180 NSSI, 163 HC). Mean age in the NSSI group (T0) was 18.1 years (SD = 2.09, range: 15–25), gender-related data is available for 166: 156 = female, 7 = male, 3 = transgender, 10 = not disclosed). In the HC group, mean age (T0) was 19.1 years (SD = 2.35, range: 15–25) (142 = female, 21 = male). At T1, 128 (71.11%) of the NSSI participants completed the questionnaires, at T2 125 (69.44%) and at T3 104 (57.78%). In the fMRI subproject, 126 adolescents participated (NSSI = 66, HC = 60, 100% female; mean age (T0): NSSI = 18.10 years, SD = 2.21; HC = 19.08, SD = 2.36).ConclusionUnderstanding predictors is of utmost importance for adequate diagnosis and intervention for NSSI. Our OS applied a multimodal investigation of social, psychological, and neurobiological parameters and is the largest sample of adolescents with NSSI to date including follow-up assessments. As health care providers require specific knowledge to develop new treatments, we believe that our in-depth assessments can potentially enhance care for youths engaging in NSSI.

Transcriptomic insights into the antagonistic responses of Antarctic marbled rockcod, Notothenia rossii, to elevated temperature and acidification

The escalating impacts of climate change, particularly ocean acidification and warming, are pivotal stressors for marine ecosystems and have profound effects on biota in polar regions. This study investigated the immunological responses of the Antarctic fish Notothenia rossii to environmental stressors indicative of future ocean conditions under the Intergovernmental Panel on Climate Change Shared Socioeconomic Pathways 5–8.5 scenario for 2100. We exposed N. rossii to conditions simulating present-day conditions: control, elevated temperature, acidification, and both stressors combined over six days. Utilizing RNA-Seq for comprehensive gene expression analysis, we identified significant upregulation and downregulation of immune-related pathways, highlighting a complex interplay of genes involved in complement and coagulation cascades, the intestinal immune network for immunoglobulin A production, cytosolic DNA sensing, natural killer cell-mediated cytotoxicity, and Interleukin 17 signaling pathways. Our findings revealed a predominantly antagonistic gene expression response, suggesting an intricate balance between energy allocation for maintaining homeostasis and the capacity of the immune system to combat stressors. This reflects a potential adaptive mechanism to combined environmental stressors, underscoring the complexity of immune responses in N. rossii and suggesting both potential vulnerabilities and resilience in the face of climate change. This study provides critical insights into the immunological impacts of acidification and warming on Antarctic marine species, emphasizing the need for further research to unravel the mechanisms underlying these observed changes and inform conservation strategies for polar ecosystems in a changing global climate.

Exploring anxiety and depression trends: insights from the BELHEALTH cohort 2022-2024 in Belgium

Abstract Background The swift impact of the COVID-19 pandemic and ensuing restrictions on the mental health of the Belgian population prompted the need for a sustainable system to monitor its evolution. Repeated COVID-19 surveys were conducted between 2020 and 2022 to address this issue, followed by the launch of the BELHEALTH cohort project. Our study aims to analyze the trajectory of anxiety and depression at the post-pandemic period, using data from five waves of the BELHEALTH longitudinal surveys from October 2022 to March 2024. High-risk groups and the potential of social support and resilience to mitigate anxiety and depression were explored. Methods The BELHEALTH follow-up cohort of around 7,300 Belgian residents uses online surveys to assess anxiety (with the GAD-7), and depression (with the PHQ-9). The analyses were performed using linear mixed models on the 3,676 individuals who participated in all five waves. Results Preliminary results indicated that more people were affected by anxiety in October 2022 (16%) compared to June 2023 (14%), while depression rates were lower in October 2022 (13%) compared to February 2023 (14%) and March 2024 (15%). However, the trajectory of mental health varied across demographic subgroups, with worse outcomes observed among unemployed and younger individuals, as well as those living alone, in the Walloon Region (South of Belgium). Overall, people with a low level of resilience or a low level of social support exhibited higher odds of experiencing depression. Conclusions Reducing these social inequities in mental health necessitates the development of structural prevention measures and interventions at the regional level. These measures should target factors such as unemployment, which is particularly prevalent among younger individuals and those living in Wallonia. Additionally, fostering protective factors such as social support and resilience is crucial for mitigating mental health inequalities over time. Key messages • Monitoring mental health and its determinants remains crucial to identify and address social inequities, tailor interventions, and support vulnerable populations. • Unemployed, younger people, and those residing in the Walloon region are at particular risk.

Роль резильєнтного потенціалу громадських організацій у відновленні територіальних громад України

The relevance of the research on the resilient potential of public organizations in Ukraine is determined by the need to increase the regenerative capabilities of territorial communities within a limited time frame and with restricted resource suport. The purpose of the article is substantiating the resilient potential of public organizations as an effective tool for increasing the adaptive capacity and self-organization of public community, mitigating the destructive consequences and accelerating recovery of territorial communities during the Russo-Ukrainian war and in post-war period. The novelty of the article consists in identifying the impact of public organizations on the resilient recovery of territorial communities in the conditions of the Russo-Ukrainian war. The research was carried out using the systems approach method, techniques of abstraction and generalization, functional and comparative analysis, statistical methods and data analysis, graphic method. The influence of public organizations on the resilience of territorial communities was analyzed by means of correlation-regression analysis. Three indicators of the resilient potential of territorial communities of the country were selected according to the criterion of significance and the existence of a cause-and-effect relationship. Namely: profitability of local budgets per person, cash income of households, the size of informally employed population as a sign of the shadow economy. The main functions of public organizations in ensuring the resilience of territorial communities have been disclosed. It is substantiated that the most effective tools for the influence of public organizations on ensuring the resilience of communities in the conditions of the war and post-war period are active means (promotion of citizens’ mobility, formation of public opinion, public control) and segmental tools (influence on certain population groups, infrastructure objects, territories etc.) with a fixed effect (legal assistance to internally displaced persons, reconstruction of the destroyed property and healthcare facilities, improvement of epidemic living conditions, ensuring the operation of a humanitarian center, collection of necessary information).

Unveiling mid-century conservation priorities: Co-occurrence of biodiversity, climate change exposure, and carbon storage in the Middle and Lower Yangtze River Basin, China

The global challenges of biodiversity loss and climate change necessitate the implementation of integrated conservation strategies. A forward-looking framework is necessary to reconcile climate change adaptation and mitigation efforts with biodiversity goals, supporting effective long-term planning and management of protected areas (PAs) network. This study develops a comprehensive approach to identify priority areas for biodiversity conservation until 2050, integrating assessments of species distributions, climate change exposure and carbon storage under distinct shared socioeconomic pathways. The Middle and Lower Yangtze River Basin (MLYRB) in China serves as a case study. Using an ensemble species distribution modeling (ESDM) method, we predicted the distributions of 435 threatened terrestrial vertebrate species and plants. We then mapped their richness in the MLYRB. Distance-based climate velocity analysis was performed to identify climate change coldspots and hotspots. The patch-generating land use simulation (PLUS) model and InVEST model were coupled to simulate carbon storage changes. Systematic conservation planning tool, Zonation, was used to prioritize species conservation hotspots. By examining the co-occurrence of these hotspots with climate change coldspots/hotspots and areas of high carbon storage, conservation priorities for the MLYRB were revealed. Our findings indicate that 18.27–24.94 % of the MLYRB risks over 20 % species richness declines by 2050 under various scenarios, while increases over 10 % are projected for only 0.81–1.75 % of the area. Co-occurrence analysis highlights significant associations, such as a 32.26 % overlap between species conservation hotspots and climate change hotspots in SSP1–2.6. Particularly noteworthy is the substantial co-occurrence (57.93–59.50 % across scenarios) between areas maximizing species conservation and carbon storage. The identified conservation priority areas, covering 41.95 % of the MLYRB (441554 km2), hold potential for long-term species conservation, climate resilience, and nature-based climate solutions by 2050. However, only 6.08 % of these priorities currently benefit from protection. These results offer valuable guidance for region-specific landscape management and conservation policy aligned with international goals. The presented methodology provides a broader application, serving as a valuable resource for prioritizing conservation efforts in other regions integrating biodiversity, climate change adaptation, and mitigation goals.

Summer primary production of Arctic kelp communities is more affected by duration than magnitude of simulated marine heatwaves.

Fjord systems in the Norwegian Arctic are experiencing an increasing frequency and magnitude of marine heatwaves. These episodic heat stress events can have varying degrees of acute impacts on primary production and nutrient uptake of mixed kelp communities, as well as modifying the biogeochemical cycling in nearshore systems where vast areas of kelp create structural habitat. To assess the impact of future marine heatwaves on kelp communities, we conducted a 23 day mesocosm experiment exposing mixed kelp communities to warming and heatwave scenarios projected for the year 2100. Three treatments were considered: a constant warming (+1.8°C from the control), a medium magnitude and long duration heatwave event (+2.8°C from the control for 13 days), and two short-term, more intense, heatwaves(5 day long scenarios with temperature peaks at +3.9°C from the control). The results show that both marine heatwave treatments reduced net community production, whereas the constant warm temperature treatment displayed no difference from the control. The long marine heatwave scenario resulted in reduced accumulated net community production, indicating that prolonged exposure had a greater severity than two high magnitude, short-term heatwave events. We estimated an 11°C temperature threshold at which negative effects to primary production appeared present. We highlight that marine heatwaves can induce sublethal effects on kelp communities by depressing net community production. These results are placed in the context of potential physiological resilience of kelp communities and implications of reduced net community production to future Arctic fjord environmental conditions.

Paediatric mass casualty response through the lens of Functional Resonance Analytical Methodology- lessons learned

BackgroundMass Casualty Incidents are rare but can significantly stress healthcare systems. Functional Resonance Analytical Methodology (FRAM) is a systematic approach to model and explore how complex systems adapt to variations and to understand resilient properties in the face of perturbations. The aim of this study was to use FRAM to create a model of a paediatric trauma system during the initial response to the Manchester Arena Attack to provide resilience-based insights for the management of future Mass Casualty Incidents (MCI).MethodsQualitative interviews in the immediate aftermath of a terrorist bombing, were followed up with further in-depth probing of subject matter experts to create a validated and verified FRAM model. This model was compared with real incident data, then simplified for future studies.ResultsA Work As Imagined (WAI) model of how a paediatric emergency department provided resilient healthcare for MCI patients from reception and resuscitation to definitive care is presented. A focused model exploring the pathway for the most severely injured patients that will facilitate the simulation of a myriad of potential emergency preparedness resilience response scenarios is also presented.ConclusionsThe systematic approach undertaken in this study has produced a model of a paediatric trauma system during the initial response to the Manchester Arena Attack, providing key insights on how a resilient performance was sustained. This modelling may provide an important step forward in the preparedness and planning for future MCIs.

Reproductive ecology of fire corals in the northern Red Sea

Scleractinian corals, the principal architects of coral reefs, face substantial threats from ongoing and anticipated climate change and other anthropogenic disturbances. This underscores the significance of investigating alternative reef-building organisms and their contribution to reefs’ resilience. Among these alternatives, colonial hydrozoans of the genus Millepora, commonly called ‘fire corals’, play substantial roles in contributing to coral reef structure and functionality by depositing calcareous exoskeletons. Despite the ecological importance of fire corals, fundamental knowledge gaps remain regarding their biology and reproductive ecology. Here, we present a comprehensive study on the population dynamics, reproductive ecology, phenology, and sex ratio of the three Red Sea fire corals—Millepora dichotoma, M. exaesa, and M. platyphylla—in the Gulf of Aqaba and Eilat. The abundance of M. dichotoma and M. exaesa seems to have remained consistent over the last 50 years across two of the three depth zones surveyed, indicating their potential resistance or resilience. However, at the third depth surveyed, their abundance appears to have decreased. Our extensive in-situ monitoring of breeding events over six consecutive years has revealed a previously undetected relationship between Millepora species breeding events and the lunar cycle. Histological analyses indicated remarkably short reproductive cycles of only 2–3 weeks, recurring multiple times within a single season, in both M. dichotoma and M. exaesa, which is a unique reproductive aspect compared to other reef-building corals. These results highlight the high reproductive and resilience potential of Millepora species. Consequently, fire corals could assume a more substantial role as keystone species in changing environments and future reefs, emphasizing their importance in reef conservation and management.

School Burnout and Emotional and Psychological Well-Being in Secondary School Students: Mediating Roles of Resilience and Hope

This study examined the mediating roles of psychological resilience and hope in the relationship between school burnout, and the well-being of students. Participants consisted of 721 Turkish secondary school students, (52.6% girls; mean age = 12.76 ± 0.82) studying from grades 5 to 8. The participants completed the School Burnout Inventory, Children’s Hope Scale, Child and Youth Resilience Measure, and Stirling Children’s Well-Being Scale. The results showed that school burnout was negatively related to resilience, hope, and well-being. Resilience and hope were positively associated with well-being. The results of structural equation modeling revealed that resilience and hope mediated the impact of school burnout on well-being. These results emphasize the potential of resilience and hope as key factors in enhancing well-being among secondary school students. They also provide a foundation for developing targeted interventions to foster well-being within the school context by promoting strength-based strategies and practices, including cultivating resilience and hope.

NMR-Based Metabolomic Analysis of Biotic Stress Responses in the Traditional Korean Landrace Red Pepper (Capsicum annuum var. annuum, cv. Subicho).

Korean landrace red peppers (Capsicum annuum var. Subicho), such as the traditional representative Subicho variety, are integral to Korean foods and are often consumed raw or used as a dried powder for cuisine. However, the known vulnerability of local varieties of landrace to biotic stresses can compromise their quality and yield. We employed nuclear magnetic resonance (NMR) spectroscopy coupled with a multivariate analysis to uncover and compare the metabolomic profiles of healthy and biotic-stressed Subicho peppers. We identified 42 metabolites, with significant differences between the groups. The biotic-stressed Subicho red peppers exhibited lower sucrose levels but heightened concentrations of amino acids, particularly branched-chain amino acids (valine, leucine, and isoleucine), suggesting a robust stress resistance mechanism. The biotic-stressed red peppers had increased levels of TCA cycle intermediates (acetic, citric, and succinic acids), nitrogen metabolism-related compounds (alanine, asparagine, and aspartic acid), aromatic amino acids (tyrosine, phenylalanine, and tryptophan), and γ-aminobutyric acid. These findings reveal the unique metabolic adaptations of the Subicho variety, underscoring its potential resilience to biotic stresses. This novel insight into the stress response of the traditional Subicho pepper can inform strategies for developing targeted breeding programs and enhancing the quality and economic returns in the pepper and food industries.