Intracerebral transplantation may also be applied therapeutically in some neurodegenerative diseases in humans, however, such a therapeutic application will require non-invasive imaging techniques to control and assess the precise location of intracerebral transplants. This chapter explores the potential of magnetic resonance imaging (MRI) to visualize intracerebral neural transplants in the rat. Possible mechanisms, which can account for the reduction of T2 values of the graft, are also discussed in the chapter with regard to anatomical characteristics of the tissue. The results demonstrate that the T2 relaxation time is significantly reduced in the neural tissue reconstructed by fetal cells grafted into the CNS of an adult host, with respect to the normal tissue, and may thus be used as a direct indicator of graft localization. The chapter suggests ways to improve the resolution of intracerebral graft imaging, such as by labeling the transplants with MRI-contrast agents. Specific markers like immunospecific Nuclear magnetic resonance (NMR) contrast agents, for example, superparamagnetic particles coupled to monoclonal antibodies or other ligands may be more interesting for the future follow-up of intracerebral neural grafts in that they can be directed specifically against certain populations of cells and, therefore, demonstrate their survival, and possibly, their functional state.