Potential Liver Donors Research Articles

Reuse of Living-Donor Liver Graft in Second Recipient with Long-Term Survival

Brain death is a rare situation after living-donor liver transplantation. However, the recipient who suffers from brain death and has functional liver graft is a potential liver donor. We report the 1st case of successful reuse of extended right living-donor liver graft after brain death of the first recipient. The first recipient, who had acute liver failure caused by hepatitis A virus, experienced brain death on the 2nd day after the transplantation. The allograft had a favorable regeneration and functional recovery. On the 7th day, the allograft was procured with a patent hepatic artery, bile duct, portal vein, and reconstructed outflow (right hepatic vein and middle hepatic vein) and successfully implanted into the second recipient. The second recipient has experienced a long-term survival without any complications.

RNA Sequencing Reveals the Suitability of Cardiac Death Livers for Transplantation.

Background Organ transplantation is considered the best treatment for end-stage organ failure. However, the lack of available organs for transplantation and the increasing number of patients waiting for transplants are primary issues facing the transplant community. Thus, developing strategies to increase the number of donors, especially for liver transplantation, has become a priority. The use of organs acquired from donors who suffered cardiac related deaths has increased the pool of potential liver donors. However, donation after cardiac death (DCD) livers increases the risk of primary graft dysfunction. Methods In the current study, we conducted transcriptome sequencing using livers from a DCD rat to assess the short-term feasibility and functional efficacy of DCD livers. RNA sequencing (RNAseq) data showed that the liver transcriptome varied greatly in rat livers subjected to 15 minutes of cardiac arrest. Results The livers used in the current study had a significant loss of normal function before transplantation. Functional and network analyses consistently indicated that transcription and translation processes were inhibited after approximately 15 minutes of cardiac arrest. Moreover, the transcriptomic sequencing data provides significant insight for identifying functional genes and testing additional biological questions in DCD liver transplantation in future studies.

Superior outcomes using normothermic regional perfusion in cDCD liver transplantation

While there is interest in its use, definitive evidence demonstrating superiority of normothermic regional perfusion in cDCD liver transplantation has not been presented. Aim: Analyze the initial Spanish experience with cDCD liver transplantation, in particular regarding the impact NRP has had on organ utilization rates and outcomes. Methods: Data was collected regarding cDCD liver donors and transplants between 2012 and 2016. Results: From 2012 to 2016, 370 potential cDCD liver donors were evaluated (152 NRP, 218 super rapid recovery). Rates of liver transplantation were 64% NRP and 57% SRR (P = 0.102). Among transplanted livers, median donor age was 57 yrs (46–65 IQR). While there were no differences in donor or recipient characteristics, functional warm ischemia was shorter with NRP – 12 min (10–16) NRP vs. 15 min (11–20) SRR – given that femoral cannulae were placed prior to withdrawal of care in the majority of cases. While rates of EAD (22% NRP, 29% SRR) and PNF (2% NRP, 4% SRR) did not vary, rates of biliary complications (9% NRP, 24% SRR, P = 0.006) and ITBL (2% NRP, 12% SRR, P = 0.01) were significantly improved with NRP. One-year graft survival was 87% NRP vs. 78% SRR (P = 0.110). On multivariate analysis analyzing risk factors for ITBL, the only significant factor was the recovery method used. Conclusions: This is the first large series describing application of NRP in cDCD liver transplantation. While results with SRR were acceptable, results using NRP were superior and comparable to those using standard-quality livers, even in spite of advanced donor age.

Evaluation of potential live donors for renal transplant: an evidence based approach and changing paradigms

Live donor renal transplantation remains the mainstay of renal replacement therapy in most countries, including Sri Lanka. The Amsterdam consensus guidelines were considered the benchmark in evaluation of live donors and used in assessing donor suitability for over two decades. However, recent evidence has cast doubts regarding the overall safety of kidney donation warranting a closer look at donor evaluation. This review aims to look at current available evidence regarding common donor conditions and the overall need for extra vigilance in donor evaluation.

Correlation between CT Volumetry and Nuclear Medicine Split Renal Function in Live Kidney Donation - A Single Centre Experience

Introduction Potential live renal donors undergo renal computed tomography angiogram (CTA) and nuclear imaging dimercaptusuccinc acid (DMSA) scans as part of their work up. CTA provides information about the anatomical structure of the kidney, whilst DMSA is considered the scan of choice for evaluating differential renal function and potential scarring. However, DMSA results are influenced by donor body habitus, kidney location, examiner, and operator disparity. The need for both imaging modalities adds another investigation for the patient, potential delays in treatment, and additional costs to the healthcare system. Aim The aim of this study was to determine the relationship between split renal volumes measured on CTA and renal volumes derived from DMSA in live renal donors. Methodology Prospectively collected data of 58 consecutive patients who underwent live laparoscopic donor nephrectomy at a single centre from 2014-2017 was reviewed. Only patients who had preoperative CTA and DMSA imaging were included. 3D reconstruction of the kidney was generated from the arterial phase CTA images using Carestream software. One investigator confirmed the renal tissue of interest prior to automated software calculation of renal volume on CTA. Split function renal volume was compared against calculated DMSA split volume (percentage split function multiplied by total renal volume). Results There were 58 live donor nephrectomies in this period. 5 were excluded because of incomplete data. 53 patients were studied. Pearson coefficient was 0.95 for right renal volume, and 0.95 on left renal volume measured on CTA and calculated on DMSA. Discussion In our cohort, split renal volumes measured on 3D images obtained from CTA correlate to calculated split volumes based on renal function determined from DMSA. In keeping with the aims of live donation in leaving the donor with the kidney with better function our results would suggest that this decision can equally be arrived at with CT renal volumetry alone. Dropping a DMSA scan in the evaluation of a kidney donor reduces the radiation load by 0.70mSv equivalent to 35 chest x rays; and a cost saving of $430.00 per donor. Conclusion Current CT technology allows accurate assessment of renal volumes that correlate well with DMSA split function.The decision of which kidney to donate is based on function and anatomy which can be achieved with A CTA as a one stop shop. Avoiding a DMSA scan results cost reduction as well as radiation in the assessment of a live donor.

Liver Biopsy Results in Potential Donor Evaluation in Living Related Liver Transplantation

Introduction Living donor liver transplantation has been increasing due to the growing discrepancy between the number of patients in waiting lists for liver transplant and the availability of deceased-donors. The evaluation of potential liver donors should ensure the safety of the surgical procedure for the donor. In addition to this, preoperative tests should identify donor grafts that pose risks for the recipient. Liver biopsy is the gold standard for selecting optimal donors. Our aim in this study is to evaluate the results of preoperative liver biopsy of potential donors. Materials and Methods Between December 1988 and October 2017, we performed 580 LT procedures at our centers (age range, 6 mo – 64 y). We evaluated the demographic features of 612 living related liver donor candidates that we performed liver biopsy between January 2001-June 2017. The histological analyses were examined. Body mass index and gender were compared in predicting the degree of histologically determined steatosis. Results We performed liver biopsy in 612 liver donor candidates (328 male, 284 female) (age range 18-69 years). Among these candidates, 416 liver biopsy were reported as normal (68%); 196 liver biopsies had pathological findings (32%). Of 196 donors with pathological findings; 86 (44%) had fatty changes, 24 (12%) had portal inflammation, 86 (44%) had other pathological findings (like fibrosis, hepatitis, focal spotty necrosis). The mean BMI with steatosis were much more higher than the mean BMI without steatosis (29.7± 3.6 vs 24.8 ± 4.2) ( p<.001). 25% of male and 15% of female donor candidates had steatosis. Conclusion The high rate of pathological findings in liver biopsy of donor candidates with healthy-appearing livers pointed the importance of liver biopsy in preoperative evaluation of donors.

Prostate Cancer in Deceased Organ Donors: Loss of Organ or Transplantation With Active Surveillance

IntroductionProstate cancer has become an important clinical issue within deceased organ donors. There is still a considerable number of undiagnosed cancers, especially in early stage, despite frozen section analysis. The aim of the study was to evaluate outcomes of orthotopic liver transplants (OLTx) with organs from donors with prostate cancer. Material and MethodsA retrospective analysis was performed in deceased liver donors whose prostate glands were harvested for histologic examinations because of prostate cancer suspicion. The study group consisted of 72 men reported as potential liver donors between 2011 and November 2017. Prostate glands were primarily assessed by frozen sections and afterward in routine examination. Generally cancer diagnosed in frozen specimen was not considered for OLTx. Recipients who received an organ from the donor with prostate cancer were actively surveilled. ResultsThere were 19 cases (26.40%) of prostate cancer diagnosed among the study group. In 12 cases diagnosis was made by frozen section assessment, of which 11 organs were disqualified from OLTx and 1 was transplanted. In 7 cases prostate cancer was diagnosed after OLTx in final routine histologic examination. Finally, 8 recipients (5 men and 3 women) received a new organ. Only 1 died during the perioperative period. In the remaining 7 patients the perioperative period was uneventful and no disease transmission was observed during follow-up. ConclusionsDiagnosis of prostate cancer in donors should not be treated as a contraindication for OLTx because the risk of disease transmission is low. Potential recipients must be fully informed and kept under oncological surveillance.

Can negligible hepatic steatosis determined by magnetic resonance imaging–proton density fat fraction obviate the need for liver biopsy in potential liver donors?

The purpose of this study is to determine whether magnetic resonance (MR)-proton density fat fraction (PDFF) estimate of negligible hepatic fat percentage (<5%) can exclude significant hepatic steatosis (≥10%) in living liver donor candidates obviating the need for liver biopsy and to perform intraindividual comparisons between MR-PDFF techniques for hepatic steatosis quantification. In an ethics-approved retrospective study, 144 liver donor candidates with magnetic resonance spectroscopy (MRS) and 6-echo Dixon magnetic resonance imaging (MRI) between 2013 and 2015 were included. A subset of 32 candidates underwent liver biopsy. Hepatic fat percentage was determined using MR-PDFF and histopathology-determined fat fraction as the reference standard. A receiver operating characteristic analysis with positive predictive value, negative predictive value (NPV), sensitivity, and specificity was performed to discriminate between clinically significant steatosis (≥10%) or not (<10%) at MRS-PDFF and MRI-PDFF thresholds of 5% and 10%. Pearson correlation and Bland-Altman analyses between MRS-PDFF and MRI-PDFF were performed for intraindividual comparison of hepatic steatosis estimation. There was significant association between MRS-PDFF and MRI-PDFF with HP-FP. High NPV of 95% (95% confidence interval [CI], 78%-99%) and 100% (95% CI, 76%-100%) as well as an area under the curve of 0.90 (95% CI, 0.79-1.0) and 0.93 (95% CI, 0.84-1.0) were obtained with a cutoff threshold of 5% MRI-PDFF and MRS-PDFF, respectively, to exclude clinically significant steatosis (≥10%). Intraindividual comparison between MRS-PDFF and MRI-PDFF showed a Pearson correlation coefficient of 0.83. Bland-Altman analysis showed a mean difference of 1% with 95% limits of agreement between -1% and 3%. MR-PDFF estimate of negligible hepatic fat percentage (<5%) has sufficient NPV for excluding clinically significant hepatic steatosis (≥10%) in living liver donor candidates obviating the need for liver biopsy. It may be sufficient to acquire only the multiecho Dixon MRI-PDFF for hepatic steatosis estimation. Liver Transplantation 24 470-477 2018 AASLD.

Liver Biopsy Results in Potential Donor Evaluation in Living Related Liver Transplant.

The number of living-donor liver transplants has been increasing due to the growing discrepancy between the number of patients on wait lists for liver transplant and the availability of deceased donations. Evaluations of potential liver donors should ensure the safety of the surgical procedure for both the donor and recipient. Liver biopsy is the criterion standard for selecting optimal donors. In this study, we evaluated the importance of preoperative liver biopsy in selecting donor candidates. We evaluated the data of 612 living-related liver donor candidates who received liver biopsies between January 2001 and June 2017 at our center. In the 612 liver donor candidates (328 male, 284 female; age range, 18-69 years), 416 liver biopsies (68%) were reported as normal and 196 liver biopsies (32%) had pathologic findings. Of 196 donors with pathologic findings, 86 (44%) had fatty changes and 24 (12%) had portal inflammation. The high rate of pathologic findings in liver biopsy of healthy-appearing donor candidates indicated the importance of liver biopsy in the preoperative evaluation of donors.

The radiological evaluation process of the potential live kidney donor assessment programme at al-Shifa Hospital: study and clinical audit

BackgroundIn 2013, al-Shifa Hospital, the largest hospital in the Gaza Strip, introduced an assessment programme for potential kidney donors on the basis of medical and radiological evaluation. The aims of this study and an associated clinical audit were to examine the final outcome of the potential live kidney donors assessment programme, to review the findings and determine the level of accuracy of the radiological evaluations, to assess the completeness and standard of radiological record keeping, and to evaluate adherence to guidelines. MethodsDonor assessment files were retrieved from the kidney transplant database in the renal department of al-Shifa Hospital. Patients who had surgery outside the Gaza Strip were excluded. Delivery of the assessment programme was assessed according to British Transplantation Society guidelines. Radiological investigations were reviewed. The head of the radiological department was interviewed to provide additional information about the approach to assessing donors and current challenges. FindingsWe retrieved files for 35 potential live kidney donors (mean age 36·82 years [range 23–54]). 32 (91%) donors had a nephrectomy, 33 (94%) donors were directed donors, and the type of donor donation was unknown for two (6%) donors. 24 (69%) donors were women, and 11 (31%) were men. 24 (69%) donors had CT angiography imaging reports as part of their pre-surgical evaluation. Digital access to those reports was limited and inefficient. Radiological assessments of renal parenchymal and renal anatomy and variants were made in 96% of cases. Of the 24 donors whose CT angiography imaging reports were retrieved, the excretory system was assessed in 16 (67%) donors, the presence of nephrolithiasis was assessed in 12 (50%) donors, and parenchymal disease was found in one (4%) donor. InterpretationThe potential live kidney donors assessment programme requires improvement to achieve an organised, consistent, and comprehensive radiological approach to assist clinical decisions, research, and quality assurance. We recommend using the latest radiology management system for an efficient workflow that can provide economical storage and convenient and timely access to images, interpretation, and digital transmission (eg, the Picture Archiving and Communication system). FundingNone.

P229 Getting renal alternative through paired exchange in Hong Kong

Aim Kidney transplantation is regarded as the most cost-effective modality of kidney replacement therapy for end stage kidney diseases. In Hong Kong, there are more than two thousand patients awaiting kidney transplantation with only less than 80 patients who can either obtain their kidney graft from deceased or living donor annually. As the demand for a kidney graft exceeds the supply, alternative source of these precious grafts is sought. The feasibility of paired exchange for patients who have a potential live donor but could not proceed for living kidney transplant because of either ABO incompatibility or positive cross-match has been investigated with the lessons learned from other countries [1] , [2] . Virtual match run for these patients to search for compatible match of two or more possibilities of transplant by exchanging donors has been performed. Methods Crossmatch results for living-related renal transplantation workup in 2012–2013 were reviewed for this feasibility study. 88 potential donor-recipient pairs comprise of 78 patients and 88 donors were included, 10 pairs (11.4%) were found to have positive crossmatch after reviewing the clinical and laboratory data. Results HLA typing, blood group, age, list of unacceptable antigens of each recipient were entered into a database together with their potential donors’ blood group and HLA typing for the match run in order to search for the best possible combination of compatible pairs. Multiple permutations of donor exchange including simple two-way and domino-pair exchange has been considered to accommodate the most number of recipients. An optimal compatible chain for the 7 donor-recipient pairs was obtained, including 1 simple two-pair exchange and a more complicated domino exchange chain donation consists of 5 donor-recipient pairs. Conclusions This virtual work up feasibility test provides evidence to prove that paired exchange of kidney transplant could facilitate compatible kidney transplants and target at creating legitimate, safe and effective transplant opportunities for eligible candidates in Hong Kong. Further study including discussion on legal and ethical aspect for the equity, justice, altruism and informed consent of the prospective pairs should be sought.

Attitudes among transplant professionals regarding shifting paradigms in eligibility criteria for live kidney donation

BackgroundThe transplant community increasingly accepts extended criteria live kidney donors, however, great (geographical) differences are present in policies regarding the acceptance of these donors, and guidelines do not offer clarity. The aim of this survey was to reveal these differences and to get an insight in both centre policies as well as personal beliefs of transplant professionals.MethodsAn online survey was sent to 1128 ESOT-members. Questions were included about several extended donor criteria; overweight/obesity, older age, vascular multiplicity, minors as donors and comorbidities; hypertension, impaired fasting glucose, kidney stones, malignancies and renal cysts. Comparisons were made between transplant centres of three regions in Europe and between Europe and other countries worldwide.Results331 questionnaires were completed by professionals from 55 countries. Significant differences exist between regions in Europe in acceptance of donors with several extended criteria. Median refusal rate for potential live donors is 15%. Furthermore, differences are seen regarding pre-operative work-up, both in specialists who perform screening as in preoperative imaging.ConclusionsRemarkably, 23.4% of transplant professionals sometimes deviate from their centre policy, resulting in more or less comparable personal beliefs regarding extended criteria. Variety is seen, proving the need for a standardized approach in selection, preferably evidence based.

Multislice computed tomography of potential liver donors

Objective: Multislice computed tomography (MSCT) prior to liver transplantation is an important aspect of the diagnosis of changes in the liver as fat infltration, as well as visualization of the individual vascular anatomy and calculation of liver volume. The aim of our study was to analyze the results of the single center experience to conduct liver MSCT of donors who are preparing for the transplant donation. Methods: We studied the MSCT evaluation results of 39 (25 male and 14 female) potential liver donors’ during the 2015 - 2016 years. Liver MSCT with various standard renovations were used for more detailed visualization of blood vessels in each liver segment. Images were obtained on 64-slice MSCT (Aquilion; Toshiba Medical Systems, Tokyo, Japan). Interpretation of the results provided in accordance with embodiments of origin of the hepatic artery, portal vein anatomy and drainage of the hepatic veins. Results: The main results of the anatomy of the hepatic artery, portal and hepatic veins are shown in Table 1, 2, 3. Based on the MSCT of 39 donor’s liver, 24 donors were identifed as appropriate for donation. 15 donors were contraindicated for donation due to: in 8 - were signs of fatty infltration, 2 donors - vascular anomaly of the portal vein, benign growths were detected in 5 donors. Conclusion: MSCT is a primary diagnostic method for the preoperative planning of surgical resection of the liver, as well as preliminary identifcation of hepatic pathology. According to the results and experience of our center, in 61.5% cases, liver donors were selected for donation and remaining 38.5% of the donors were excluded from organ donation, in connection with the identifed contraindications.

Validation of intimate correlation between visceral fat and hepatic steatosis: Quantitative measurement techniques using CT for area of fat and MR for hepatic steatosis

The relationship between obesity and hepatic steatosis is well known, and there are many methods to measure obesity and severity of hepatic steatosis. Because of advances in radiologic techniques, the areas of certain body components can be measured on computed tomography (CT) while the severity of hepatic steatosis can be measured by magnetic resonance spectroscopy (MRS) with high accuracy. The aim of this study is to investigate the relationship between degree of fatty infiltration of the liver measured by MRS and body composition measured from CT images. We evaluated 95 potential liver donors who underwent abdomen CT and liver MRI (including MRS) between February 2014 and September 2015 in a tertiary university hospital. Body composition analysis was performed on CT images using commercial software. The areas of subcutaneous fat, visceral fat and abdominal circumference were measured automatically and the area of muscle was measured semi-automatically. The degree of hepatic steatosis was measured by MRS. The degree of hepatic steatosis showed a significant correlation with total fat area, visceral fat area, subcutaneous fat area, muscle area, abdominal circumference, BMI, and ratio of visceral fat to total fat. The strongest correlation was between hepatic steatosis and the area of visceral fat in all subjects (r=0.569). Multivariate regression analysis showed that male gender and visceral fat area were significantly associated with hepatic steatosis (P=0.031, <0.001, respectively). The area of visceral fat has the most intimate correlation to the severity of hepatic steatosis among all significantly correlated parameters associated with body habitus. Accurate and quantitative body composition measurement and degree of hepatic steatosis can be noninvasively performed using advanced radiological techniques.

Report on Liver Cell Transplantation Using Human Fetal Liver Cells.

In an era of organ shortage, human fetuses donated after medically indicated abortion could be considered a potential liver donor for hepatic cell isolation. We investigated transplantation of fetal liver cells as a strategy to support liver functionality in end-stage liver disease. Here, we report our protocol of human fetal liver cells (hFLC) isolation in fetuses from 17 to 22 gestational weeks, and our clinical procedure of hFLC transplantation through the splenic artery.

Additive value of non-contrast MRA in the preoperative evaluation of potential liver donors

The purpose of this study is to compare diagnostic quality, inter-observer variability and agreement of non-contrast enhanced MRA (NC-MRA) with contrast-enhanced MRA (CE-MRA) in the evaluation of hepatic arterial anatomy. 20 potential liver donors were included in this retrospective study. NC-MRA, CE-MRA and combined data sets were randomized and reviewed by two readers. Reference standard was consensus by two senior radiologists using all data including CTA. There was no difference in IQ or diagnostic confidence between NC-MRA, CE-MRA or combined data for either reader but the arterial origin of segment IV was successfully identified on NC-MRA when CE-MRA was suboptimal.

Predictors and Moderators of Educational Interventions to Increase the Likelihood of Potential Living Donors for Black Patients Awaiting Kidney Transplantation.

Our aim was to identify predictors and moderators of the effects of a house calls (HC) educational intervention, relative to a group-based (GB) intervention and to individual counseling (IC), in a randomized controlled trial to increase the likelihood of having living donor (LD) evaluations initiated and live donor kidney transplantation (LDKT). Black adults wait listed for kidney transplantation (N=152) were randomized into one of the three educational conditions. We examined demographic, clinical, psychosocial, and socio-contextual baseline characteristics as predictors and moderators of having a potential LD initiate evaluation. HC assignment (OR=2.024.7311.05, P=0.001), younger age (OR=0.910.940.98, P=0.001), more willingness to discuss donation with others (OR=1.081.371.75, P=0.01), and larger social network (OR=1.011.091.18, P=0.04) were significant multivariable predictors of having ≥1 LD initiate evaluation. Age (P=0.03) and social network size (P=0.02) moderated the effect of HC relative to IC and GB, but not GB relative to IC, on LD evaluation initiation. Our findings suggest that HC is most effective for patients <60years old and those with average or large social network size.

Comparison of gadoxetic acid to gadobenate dimeglumine for assessment of biliary anatomy of potential liver donors.

To compare MRI using gadobenate dimeglumine (Gd-BOPTA) vs. gadoxetic acid disodium (Gd-EOB-DTPA) for the assessment of biliary anatomy of potential liver donors. 76 potential liver donors (39M/37F, mean 38years) who underwent 1.5T MRI using Gd-BOPTA (n=37) or Gd-EOB-DTPA (n=39) were retrospectively evaluated. T2 cholangiogram (T2 MRC) and delayed hepatobiliary phase (HBP) T1 cholangiogram (T1 MRC) (performed during HBP 20min after injection of Gd-EOB-DTPA and 1-2h after Gd-BOPTA injection) were obtained in addition to MR angiogram/venogram. Two independent observers evaluated image quality (IQ) and conspicuity scores (CS) of the biliary system. Biliary anatomy was assessed in 3 reading sessions (T2 MRC, T1 MRC, and combined T2/T1 MRC). Reference standard consisted of consensus reading of two separate observers of all image sets, clinical/surgical information and intraoperative cholangiogram when available. Datasets were compared using the Mann-Whitney U test or Chi-squared test. There was no difference in IQ for T1 MRC using either contrast agent or T2 MRC vs. T1 MRC for both observers (all p values >0.07). There was superior CS for T2 MRC vs. Gd-BOPTA T1 MRC for both observers and T2 MRC vs. Gd-EOB for one observer (p<0.001). No difference was found for biliary variant detection for T1 MRC (with either contrast agent) vs. T2 MRC. Combined T2/T1 MRC demonstrated improved sensitivity for biliary variant detection using Gd-BOPTA for both observers (p<0.004) and Gd-EOB-DTPA for one observer (p<0.001). Equivalent image quality was found for T1 MRC obtained with Gd-BOPTA or Gd-EOB-DTPA and T2 MRC. T1 MRC is equivalent to T2 MRC for detection of variant biliary anatomy, and the combination of sequences may have added value.

Imaging in pediatric liver transplantation.

Liver transplantation has become an established curative treatment in adult patients with acute or chronic end-stage liver diseases. In pediatric cases the number of cadaveric donor livers is not sufficient and to overcome the shortage of appropriate-sized whole liver grafts, technical variants of liver transplantation have been practiced. Reduced-size cadaveric and split cadaveric allografts have become an important therapeutic option, expanding the availability of size-appropriate organs for pediatric recipients with terminal liver disease. The number of pediatric deaths awaiting liver transplantation has been reduced by the introduction of living-related liver transplantation, developed to overcome the shortage of suitable grafts for children. It is important for radiologists to know that children have distinct imaging of liver transplantation that distinguish them from adults. A multidisciplinary pediatric liver transplantation team should be skilled in pediatric conditions and in associated processes, risks and complications. Radiologists should know the common pediatric liver diseases that lead to liver transplantation, the anastomotic techniques and the expected postoperative imaging findings. The aim of this study is to illustrate the role of non-invasive imaging such us ultrasonography, color Doppler ultrasonography, multidetector computed tomography and magnetic resonance imaging in the evaluation of pediatric liver transplantation and in potential liver donors.

FRI-291 - Predicting Fatty Liver Disease in Healthy Potential Liver Donors

FRI-291 - Predicting Fatty Liver Disease in Healthy Potential Liver Donors