Potential Game Changer Research Articles

Optimizing the cascade of prevention to protect people from tuberculosis: A potential game changer for reducing global tuberculosis incidence.

The provision of tuberculosis preventive treatment is one of the critical interventions to reduce tuberculosis incidence and ultimately eliminate the disease, yet we still miss appropriate tools for an impactful intervention and treatment coverage remains low. We used recent data, epidemiological estimates, and research findings to analyze the challenges of each step of the cascade of tuberculosis prevention that currently delay the strategy implementation. We addressed research gaps and implementation bottlenecks that withhold key actions in tuberculosis case finding, testing for tuberculosis infection, provision of preventive treatment with safer, shorter regimens and supporting people to complete their treatment. Empowering communities to generate demand for preventive therapy and other prevention services in a holistic manner and providing adequate financial support to sustain implementation are essential requirements. The adoption of an effective, universal monitoring and evaluation system is a prerequisite to provide general and granular insight, and to steer progress of the tuberculosis infection strategy at global and local level.

Incorporating Technology Adoption in Medical Education: A Qualitative Study of Medical Students' Perspectives.

The integration of technology into medical education has witnessed significant growth in recent years, with tools such as virtual reality, artificial intelligence, and telemedicine gaining prominence. These tool in medical education, offering immersive, experiential learning experiences. We approached medical students currently enrolled in medical education programs and who are familiar with and actively use AI in medical education. Initially, we invited 21 random students to participate in the study; however, only 13 agreed to interviews. Some students cited their busy exam schedules as the reason for not participating. The participants were informed of the objective of the study before the commencement of the recorded interviews. Semi-structured interviews were used to guide the record interviews. Audio recordings were transcribed and analyzed using Atlas.ti, a qualitative data analysis software. Participants exhibited a diverse range of perceptions and levels of awareness regarding VR, AI, and telemedicine technologies. Learning with virtual reality was considered to be fun, memorable, inclusive, and engaging by participants. The use of virtual reality technology is seen as complementing current teaching and learning approaches, helping to build learners' confidence, as well as providing medical students with a safe environment for problem-solving and trial-and-error learning. The students reported that AI was seen as a potential game-changer in the healthcare sector. Participants hoped that telemedicine would provide healthcare services to remote and underserved populations. The study conducted focus group discussions with medical students and residents in Saudi Arabia to explore their views on integrating VR, AI, and telemedicine in medical education and practice. Their insights highlight the need for informed decision-making and strategic development to optimize the benefits and address challenges like initial investments, technical issues, ethics, and regulations. These considerations are crucial for fully realizing the potential benefits of technology in medical education globally.

Can artificial intelligence help improve the rehabilitation of anterior cruciate ligament injuries in basketball players?

For basketball players, a torn anterior cruciate ligament (ACL) can be devastating [1]. This injury often necessitates reconstructive surgery, followed by a grueling rehabilitation process that can sideline an athlete for months, jeopardizing their career trajectory [2]. However, a new beacon of hope is emerging on the horizon: artificial intelligence (AI). This powerful technology is not just a tool but a potential game-changer, rapidly transforming the way ACL recovery is approached. It offers the potential for faster, more personalized, and ultimately more successful outcomes for athletes eager to return to the court, inspiring a new era in sports medicine [3].

Exploring uncharted territory: new frontiers in environmental DNA for tropical fisheries management.

Tropical ecosystems host a significant share of global fish diversity contributing substantially to the global fisheries sector. Yet their sustainable management is challenging due to their complexity, diverse life history traits of tropical fishes, and varied fishing techniques involved. Traditional monitoring techniques are often costly, labour-intensive, and/or difficult to apply in inaccessible sites. These limitations call for the adoption of innovative, sensitive, and cost-effective monitoring solutions, especially in a scenario of climate change. Environmental DNA (eDNA) emerges as a potential game changer for biodiversity monitoring and conservation, especially in aquatic ecosystems. However, its utility in tropical settings remains underexplored, primarily due to a series of challenges, including the need for a comprehensive barcode reference library, an understanding of eDNA behaviour in tropical aquatic environments, standardized procedures, and supportive biomonitoring policies. Despite these challenges, the potential of eDNA for sensitive species detection across varied habitats is evident, and its global use is accelerating in biodiversity conservation efforts. This review takes an in-depth look at the current state and prospects of eDNA-based monitoring in tropical fisheries management research. Additionally, a SWOT analysis is used to underscore the opportunities and threats, with the aim of bridging the knowledge gaps and guiding the more extensive and effective use of eDNA-based monitoring in tropical fisheries management. Although the discussion applies worldwide, some specific experiences and insights from Indian tropical fisheries are shared to illustrate the practical application and challenges of employing eDNA in a tropical context.

Investigating social and environmental hotspots throughout the lifecycle of product-service systems in the early design stages

Product-Service Systems (PSS) have been recognized as potential game-changers for advancing sustainability. However, the sustainability of a PSS over traditional products and services is not automatic; it requires careful, intentional design. Despite a decade's progress in relevant literature, early-stage design assessment of a PSS – particularly from a life cycle standpoint and considering the social sustainability dimension – remains underexplored. This study introduces a framework for early-stage identification and analysis of potential environmental and social impacts within a PSS's life cycle to aid in decision-making and guide towards sustainable solutions. The framework's hotspot analysis, which combines life cycle assessment techniques, aims to pinpoint life cycle stages most susceptible to significant environmental and social impacts. Drawing on existing literature and expert evaluations, this approach offers designers preliminary insights into potential impacts, establishing a groundwork for comprehensive life cycle analysis once more detailed information on products, services, and organizational structures becomes available. The hotspot analysis not only addresses the lifecycle view of a PSS but also places emphasis on the oft-neglected social dimension of sustainability, marking an area ripe for further study. By supporting decision-making in the early design phase and encouraging scrutiny of various PSS concepts, this approach promotes the cultivation of sustainably-designed solutions.

Use of peptide nucleic acid probe to determine telomere dynamics in improving chromosome analysis in genetic toxicology studies

Genetic toxicology, strategically located at the intersection of genetics and toxicology, aims to demystify the complex interplay between exogenous agents and our genetic blueprint. Telomeres, the protective termini of chromosomes, play instrumental roles in cellular longevity and genetic stability. Traditionally karyotyping and fluorescence in situ hybridisation (FISH), have been indispensable tools for chromosomal analysis following exposure to genotoxic agents. However, their scope in discerning nuanced molecular dynamics is limited. Peptide Nucleic Acids (PNAs) are synthetic entities that embody characteristics of both proteins and nucleic acids and have emerged as potential game-changers. This perspective report comprehensively examines the vast potential of PNAs in genetic toxicology, with a specific emphasis on telomere research. PNAs' superior resolution and precision make them a favourable choice for genetic toxicological assessments. The integration of PNAs in contemporary analytical workflows heralds a promising evolution in genetic toxicology, potentially revolutionizing diagnostics, prognostics, and therapeutic avenues. In this timely review, we attempted to assess the limitations of current PNA-FISH methodology and recommend refinements.

Economic impacts of power-to-liquid fuels in aviation: A general equilibrium analysis of production and utilization in Germany

The aviation industry faces an urgent need to adopt sustainable aviation fuels for significant decarbonization. Power-to-Liquid (PtL) fuel is considered a potential game changer, but questions remain about the wider economic impacts of introducing PtL fuel in the aviation sector. This paper examines the economic impacts of introducing PtL fuel blending quotas along with a price policy consisting of a kerosene tax and PtL fuel subsidies for the case of Germany. Based on a detailed supply chain analysis, we apply a social accounting matrix and a computable general equilibrium model to take into account both, the production and utilization perspectives of PtL jet fuel. Our results show that the influence of low blending quotas is mainly limited to the aviation sector, with a 10 % blending quota increasing consumer prices by 7.9 % and reducing aviation industry output by 3.1 %. When quota levels increase, however, the effects go beyond the air transport system. On inter-sectoral level, we identify three main patterns: First, industries that substantially contribute to the PtL fuel supply chain, such as metal products and electrical equipment, see increasing levels in both, domestic production, and imports. Second, aviation upstream industries like transport infrastructure and aircraft production see reduced domestic production and imports. Third, aviation downstream industries, such as delivery services and travel agencies, see substitution effects, where imports partly replace domestic output. Macroeconomic indicators are affected negatively by the quota scenarios, but the relative impact is low as the maximum decrease in the gross domestic product (GDP) does not exceed 0.35 %. PtL fuel production subsidies can largely mitigate the decrease in aviation demand but come at the cost of a stronger reduction in the GDP and government income. Moreover, the sensitivity analysis emphasizes that various assumptions and parameters, such as the cost projections of PtL fuel, import options, and elasticities of demand, affect the intensity of economic consequences. Our analysis implies the trade-offs of policymaking between sectoral and macroeconomic interests in the context of sustainable fuels. The main contribution of this study is the investigation of the broader economic effects resulting from the adoption of PtL fuels in aviation. In particular, the production as well as the utilization perspective are considered simultaneously in this study.

Syrian Immigrants in the Malta Bazaar of Istanbul: Changing Rules of the Trade Game and Negotiation between the Capitals

ABSTRACT This article examines the socio-spatial transformations of the Malta Bazaar in Istanbul and the new Syrian shopkeepers as potential game changers. We argue that the transformation of the bazaar cannot be seen solely as a commercial venture, but can also be read as a dynamic playground of understanding and tolerance, as well as emerging social, cultural and economic contrasts and tensions. To test these arguments, we designed a field study with an ethnographic approach. The central theme of our research is to read the role of Syrians in the social reproduction of space through potential changes in the rules of the game in a micro-space. We adopted Pierre Bourdieu's concepts of field and habitus to relate the micro-level experiences of actors in space to broader macro contexts. As a result, we concluded that the change in the rules of the game should be defined as a process of mutual uneasiness. What happens in the field at this stage is an attempt to fit into a single space where negotiation rather than cooperation is more prominent and mutual compromises are inevitably made.

Metallacarboranes in Medicinal Chemistry: Current Advances and Future Perspectives.

Metallacarboranes, exemplified by cobalt bis(dicarbollide) ([COSAN]-), have excelled their historical metallocene analogue label to become promising in drug design, medical studies, and fundamental biological research. Serving as a unique platform for conjugation with biomolecules, they also constitute an auspicious building block for biologically active derivatives and a carrier for cellular transport of membrane-impermeable cargos. Modified [COSAN]- exhibits specific antimicrobial, antiviral, and anticancer actions showing promise for preclinical trials. Contributing to the ongoing development in medicinal chemistry, metallacarboranes offer desirable physicochemical properties and low acute toxicity. This article presents a critical look at metallacarboranes in the context of their application in medicinal chemistry, emphasizing [COSAN]- as a potential game-changer in drug design and biomedical sciences. As medicinal chemistry seeks innovative building blocks, metallacarboranes emerge as an important novelty with versatile solutions and promising implications.

The Rafael gas-condensate discovery – a potential game-changer in the Canning Basin

The Rafael 1 exploration well discovered an abnormally high-pressured gas-condensate pool in the Kimberley region in late 2021. Data supports a minimum gross gas column of 165 m at the well location trapped within a large faulted four-way closure in a dolomite reservoir sequence with strong similarities and age equivalent to the oil-bearing Ungani Dolomite reservoir in the Ungani Field. A successful production test in March 2022 resulted in sustained natural flows of gas and condensate to surface. The presence of thick sandstones of the Anderson Formation and a complete Laurel section beneath the Meda Unconformity were unexpected based on the pre-drill interpretation. Serendipitously, it provided the perfect geological setting for a significant hydrocarbon accumulation and emphasised the need to consider multiple geological scenarios when evaluating prospects to capture the full range of uncertainties and potential pool sizes. Although the range in size of the contingent resources is wide and requires further drilling for refinement, the Rafael 1 discovery could be one of the most significant onshore gas discoveries since Waitsia 1 and provides impetus and incentive for continued exploration in the basin. Several pathways for commercialisation have been identified linked to the resource size. A comprehensive appraisal program is underway including the recently completed acquisition of a 200 km2 3D seismic survey to optimally locate wells, and plans for drilling to reduce uncertainty and support the first phase of development based on a low case contingent resource that could underpin the energy needs of the Kimberley region.

A Method for Straightening Distorted Giga-Cast Large Thin-Walled Components.

Giga-casting, a revolutionary approach for manufacturing large, single-piece car body components from aluminium, has emerged as a potential game-changer in the automotive industry. However, these large, thin-walled castings are prone to distortions during solidification and heat treatment processes. Straightening these distortions is crucial to ensure structural integrity, facilitate downstream assembly, and maintain aesthetic qualities. This paper proposes a novel method for straightening giga-cast components using a multi-pin straightening machine. The machine's versatility stems from its ability to adapt to various geometries through multiple strategically controlled straightening pins. This paper introduces the concept of a "straightening stroke decision algorithm" to achieve precise straightening and overcome the challenges of complex shapes. This algorithm determines the stroke length for each pin, combining a polynomial model representing the global stiffness of the component with a machine learning model that captures the stiffness changes arising from the current geometry. The effectiveness of the proposed approach is evaluated through comprehensive numerical experiments using finite element analyses. The straightening performance is assessed for the straightening algorithm with different machine learning models (deep neural network and XGBoost) and compared to a traditional optimisation method. The proposed surrogate models decided the straightening strokes so that the maximum remaining distortion became 0.02% of the largest dimension of each target geometry. The results of the numerical experiment showed that the proposed straightening method is suitable for straightening distortion in large thin-walled components.

O2− substituted Li-richened Li2ZrCl6 lattice towards superionic conductivity

Emerging halide superionic conductors with remarkable oxidative stability and deformability, making them a potential game-changer for high-performance all-solid-state Li batteries (ASSLBs). The recently reported Li2ZrCl6 (LZC) with low cost possess great potential. However, its ionic conductivity at 25 °C is below 1 mS cm−1. Herein, we developed a Li-richened strategy to LZC by doping O2− at Cl− site via a mechanochemical method to form oxychloride electrolytes Li2+xZrCl6−xOx (0 ≤ x ≤ 1.8), resulting in high ionic conductivity up to 1.46 mS cm−1 at room temperature (RT). The experimental results and theoretical calculations (ab initio molecular dynamics simulations) demonstrate that the Li2O doping leading to a Li-richened LZC lattice effectively enhances the Li+ conductivity in solid-state electrolytes (SSEs). Significantly, an increasing O2− substitution in the Li2+xZrCl6−xOx microcrystalline framework induces a progressive structural evolution from triangular to monoclinic phases, accompanied by a redistribution of Li+. Furthermore, the ASSLBs formed by Li3.4ZrCl4.6O1.4 (LZCO) with Li-In anode and bare LiCoO2 cathode shows excellent long-term cycling stability (94 % capacity retention for 600 cycles at 1 C) and high-rate performance (105.7 mAh g−1 at 2 C). This exploratory study provides a promising strategy to facilitate the application of low-cost LZC-based SSEs for high-performance ASSLBs.

Blockchain integration in healthcare: a comprehensive investigation of use cases, performance issues, and mitigation strategies.

Healthcare is a critical area where blockchain technology (BT) is being heralded as a potential game-changer for facilitating secure and efficient data sharing. The purpose of this review is to examine BT applications, performance challenges, and solutions in healthcare. To begin, This review paper explores popular blockchain networks for data exchange, encompassing both public and permissioned platforms, such as Ethereum and Hyperledger Fabric. This paper analyzes the potential applications of BT's decentralized, immutable, and smart contract capabilities in healthcare settings, including secure and interoperable health data exchange, patient consent management, drug supply chain oversight, and clinical trial management. The healthcare industry might greatly benefit from the increased privacy, transparency, and accessibility that these technologies provide. Despite BT's promising medical uses, the technology is not without its drawbacks. High energy consumption, throughput, and scalability are all concerns. We wrapped up by discussing the solutions that have been implemented, including consensus processes, scalability measures like sharding, and off-chain transactions that are designed to mitigate the drawbacks.

Navigating the Promise and Perils: Artificial Intelligence in Assisted Reproductive Techniques

The inclusion of artificial intelligence (AI) into assisted reproductive techniques (ART) represents a significant advancement in the field of reproductive medicine. AI shows the confidence of enhancing various aspects of ART, including treatment optimization, embryo selection, and predictive modeling. However, as with any emerging technology, the adoption of AI in ART necessitates careful consideration of ethical, legal, and social implications. This editorial aims to explore the dual role of AI in ART as a potential game-changer while emphasizing the need for caution and ethical blunder.

Emergency Swarm: A Digital Fabrication Collective for Post-disaster Scenarios

Earthquakes in Turkey serve as unfortunate reminders etched in collective memory. Despite years of preparation by governmental and civil organizations for the devastating impacts of earthquakes, organizational challenges persist in the post-disaster. Disasters like the February 6 earthquakes, for which we directed all available resources post-disaster, often exceed the capacity of existing organizations. To address such limitations in the future, the integration of digital fabrication tools and artificial intelligence supported organization of civil collectives emerges as a potential game-changer in disaster management. Within this framework, the paper delves into open-source architectural approaches, placing digital fabrication tools at the forefront, and explores their application in emergency scenarios. The culmination of this research proposes the formation of a collective named Emergency Swarm, managed by artificial intelligence bots through the Discord network. The paper details the flow of data within this network and outlines how stakeholders will interact. The conclusion sparks a discussion on the future directions and applications of this innovative network, contemplating its potential to revolutionize disaster response strategies and enhance the resilience of communities in the face of unforeseen challenges.

The White Gold Rush and The Pursuit of Natural Hydrogen

The buzz around natural hydrogen – dubbed white or gold hydrogen – is gaining global momentum as a potential gamechanger in the hunt for cost-effective, low-carbon energy sources. Rystad Energy research shows that at the end of last year, 40 companies were searching for natural hydrogen deposits, up from just 10 in 2020. Currently, exploratory efforts are underway in Australia, the US, Spain, France, Albania, Colombia, South Korea and Canada.

Drone technologies - a potential game-changer?

Drone technologies - a potential game-changer?

Looking beyond the hype: The challenges of blockchain adoption in accounting

Blockchain has been hyped and considered a potential game-changer for the recording of accounting transactions as it enables triple-entry accounting and real-time reporting. However, there is very little knowledge of the uptake of blockchain in accounting, and most blockchain accounting research is conceptual, lacking empirical evidence. This study addresses this gap and examines the organisational factors that drive and hinder the adoption of blockchain in accounting, as well as the perceived benefits. Using the technology-organisation-environment (TOE) framework, we analyse interview data collected from blockchain experts and accountants (N = 19). The findings confirm the influence of nine context-specific factors, highlighting the challenges and lack of knowledge in understanding the usage and benefits of blockchain in accounting, its complex integration with existing accounting systems, and the increased costs associated with the adoption intention. This study provides novel empirical evidence of the factors by adequately contextualising an established theoretical framework in the context of accounting. The findings are useful for practitioners and the broader accounting information systems research community as they provide empirical insights into how context-specific factors influence blockchain adoption in accounting.

Progovernment militias, identity leadership, and ethnic defection: Evidence from Israel's recruitment of the South Lebanese Army

AbstractEthnic defection has been identified as a potential game changer in conflicts. However, the factors that enable this process require further study. One factor that has been often overlooked is that of social identity and, more particularly, identity leadership. Ethnic defection is a social as much as it is a political process. Incumbents who can utilize this element may be more successful in encouraging a continuous and more persistent process of ethnic defection. A particularly useful tool for counterinsurgency (COIN) leaders to function as identity leaders is that of militias. Traditionally perceived in the literature as ad hoc outcomes of defection, this article demonstrates how militia recruitment can serve as a platform for recruiters to serve as identity leaders and create among recruits a distinct sense of identity that further distances them from other group members and strengthens their group identity. Success in enabling this group categorization could pave the way for more defectors to switch to the government side in a way less relevant than material incentives. The article illustrates this process by employing the case of Israel's recruitment of Shi‘a defectors into pro‐Israel militias in South Lebanon and the Security Belt during the 1980s and 1990s.

Revealing the Crucial Role and Prospect of Nano-biofertilizers for Improving Soil Health and Advancing Sustainable Crop Productivity

Summary In recent years, the agriculture practices have seen a growing interest in innovative technologies aimed at enhancing productivity while promoting sustainability. Nano-biofertilizers, a novel approach to crop nutrition, have emerged as a potential game-changer. This study is aimed comprehensively to uncover the potential and current utilization status of nano-biofertilizers in soil health improvement and sustainable enhancement of crop productivity. The methodology used in this study involved the application of systematic literature review (SLR) methods in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review focused on scientific literature published from 2013 to 2023, utilizing databases such as ScienceDirect, Scopus, and PubMed. A total of 631 articles were identified through this process. Out of this pool, 10 articles were chosen based on their relevance and topic and they underwent a comprehensive and detailed review. The results showed that use of nano-biofertilizers improves the soil health, plant growth, and productivity significantly. The biological selenium nanoparticles (100 mg/mL) significantly increased the length and weight of spike, root, and shoot, grain quantity in spike, and 1000 grain weight by 5%–40% compared to control. Comamonas testosteroni biofertilizer combined with silver nanoparticles (AgNPs) could alleviate the salinity threatening plant growth. Nano-biofertilizers enhance plant growth, elevate their nutritional value, improve productivity, extend shelf life, and bolster their defenses against biotic and abiotic stress factors.