Potential Cost Savings Research Articles

Utility-based context-aware multi-agent recommendation system for energy efficiency in residential buildings

A significant part of CO2 emissions is due to high electricity consumption in residential buildings. Using load shifting can help to improve the households’ energy efficiency. To nudge changes in energy consumption behavior, simple but powerful architectures are vital. This paper presents a novel algorithm of a recommendation system generating device usage recommendations and suggests a framework for evaluating its performance by analyzing potential energy cost savings. As a utility-based recommender system, it models user preferences depending on habitual device usage patterns, user availability, and device usage costs. As a context-aware system, it requires an external hourly electricity price signal and appliance-level energy consumption data. Due to a multi-agent architecture, it allows for easy integration of new agents, enabling seamless functionality expansion, or the disabling of existing agents to tailor the system to specific needs. Empirical results show that the system can provide energy cost savings of 18% and more for most studied households.

Cost-Outcome of Radiotherapy for Local Control and Overall Survival Benefits in Breast Cancer

PurposeRadiotherapy (RT) is an integral component in the treatment of breast cancer. The aims of this study were to estimate the cost per 5-year Local Control (LC) and Overall Survival (OS) benefits of the first course of RT, based on breast cancer stage, and the potential cost savings with adoption of the FAST-Forward protocol. Methods and MaterialsAll RT activities for breast cancer RT July 2017-June 2020 and their associated costs were consolidated together. The average cost of treatment course was calculated (average cost per fraction X average no. of fractions). Cost per outcome was estimated based on published gains in 5-year LC and OS with optimal use of radiotherapy. Results481 patients with breast cancer were analysed. The average cost per fraction was $285 AUD (£148 GBP) for all stages. The average costs for 5-year LC and OS gain were $31,483 AUD (£16 392 GBP) and $235,435 AUD (£122 566 GBP) respectively for all stages.The estimated costs for 5-year LC outcomes were $29,675 AUD (£15 450 GBP), $34,675 AUD (£18 053 GBP) and $32,478 AUD (£16 910 GBP) for Stage I-III respectively. The estimated costs for 5-year OS were $455,909 AUD (£237 378 GBP), $532,727 AUD (£ 277 375 GBP) and $60,717 AUD (£31 614 GBP) for Stage I-III respectively.266 patients had characteristics that made them eligible for the FAST-Forward protocol. A cost saving of $2592–3864 AUD (£1350–2012 GBP) per patient was estimated had these patients been treated with the protocol. ConclusionsThe cost of RT for LC outcome is similar across stages. The greatest value for OS outcome was seen in patients with Stage III breast cancer, due to the greater survival benefit with RT in these patients compared with Stage I-II breast cancer. Significant cost savings can be made by implementing the FAST-Forward protocol.

Healthy Eating Patterns Are Associated With Potential Savings in Medical and Productivity Losses Costs of Cardiovascular Disease in Kuwait: A Cost-of-Illness Analysis

Healthy Eating Patterns Are Associated With Potential Savings in Medical and Productivity Losses Costs of Cardiovascular Disease in Kuwait: A Cost-of-Illness Analysis

The Price of Water: Evaluating the Potential Cost Savings of Switching from Saline to Distilled Water for Wound Irrigation

As water becomes an increasingly precious commodity, health systems face difficulties in balancing usage and costs. Numerous studies indicate minimal differences in patient outcomes between the use of normal saline and tap water in wound care and surgical procedures. The aim of this study is to evaluate the potential cost implications for hospitals when shifting from sterile water and saline to in-house distilled water for wound care and surgical procedures. We analyzed a two-facility hospital network, assessing current sterile water and saline solution usage and expenses and compared it with the cost of implementing an in-house water distillation system. In 2022, the hospital network spent $305,180.78 on sterile water and saline solution bottles. By replacing the current expenditure on sterile water and saline solution bottles for irrigation with a water distillation plant at the hospital network, the estimated annual cost of the new system is projected to be significantly lower, at $83,298.87. This results in substantial total savings of $221,881.91 annually, amounting to $361.37 per bed per year, while also considering the additional benefit of reducing plastic disposal costs. Extrapolating the in-house distillery cost savings to all 919,649 staffed hospital beds in the United States could potentially save approximately $565 million annually. Over a decade, this could reach up to $5.65 billion, if all hospitals adopt similar self-hosted water distillation systems.

Application of Material Flow Cost Accounting to Soybean Oil Production Process: A Systematic Review

Purpose –This study aims to provide an in-depth review of the application of the material flow cost accounting (MFCA) technique. It also provides a detailed account of how the technique can be applied in soybean oil processing, emphasizing its significance, key components, and potential benefits. Methodology - This paper adopts the literature review approach to explain the impact of applying the MFCA technique to the soybean oil production process. It provides insights into how MFCA can be effectively applied and implemented in this context. It aims to identify and quantify the environmental and economic costs associated with material usage, waste generation and management, and energy consumption. Findings - When applied to soybean oil production, MFCA provides insights into process efficiency, waste reduction opportunities and potential cost savings. It is concluded that applying the MFCA technique to the soybean oil production process will bring about cost reduction, waste reduction and environmental sustainability. Implications – The study’s scope and focus did not include a practical application of the MFCA technique to the soybean oil production process. However, if all the steps discussed in this study are diligently followed, it is believed that the technique can be successfully applied in soybean oil production. Originality – The study provides an original insight into the application of the MFCA technique, which is yet to be done to the best of the researchers’ knowledge.

Effectiveness of Autologous Skin Cell Suspension in Large Total Body Surface Area Burns: Analysis of Clinical Outcomes and Patient Charges.

Autologous skin cell suspension (ASCS) is an adjunct to conventional split-thickness skin grafts (STSG) for acute burns, enhancing healing and reducing donor site requirements. This study validates ASCS's predictive benefits in hospital stay reduction and cost savings by analyzing outcomes and real-world charges post-ASCS implementation at a single institution. A retrospective study (2018-2022) included burn patients with ≥10% TBSA. The study population comprised 2 groups: burns treated either with a combination of ASCS ± STSG or with STSG alone. Outcomes included LOS, surgeries, infection, complications, days on antibiotics, and adjusted charge per TBSA. The ASCS ± STSG group demonstrated significantly shorter LOS (Mdn: 16.0 days, IQR: 10-26) than the STSG group (Mdn: 20.0 days, IQR: 14-36; P = .017), and fewer surgeries (Mdn: 1.0, IQR: 1-2) versus the STSG group (Mdn: 1.0, IQR: 1-4; P = .020). Postoperative complications were significantly lower in ASCS ± STSG (11% vs. 36%; P < .001). The STSG group had a longer distribution of antibiotic days (IQR: 0-7.0, min-max: 0-76) than the ASCS ± STSG group (IQR: 0-0, min-max: 0-37; P = .014). Wound infection incidence did not differ (P = .843). ASCS ± STSG showed a lower distribution of adjusted charge per TBSA (IQR: $10 788.5-$28 332.6) compared to the STSG group (IQR: $12 336.8-$29 507.3; P = .602) with a lower mean adjusted charge per TBSA ($20 995.0 vs. $24 882.3), although this was not statistically significant. ASCS ± STSG utilization demonstrated significant reductions in LOS, surgeries, postoperative complications, antibiotics, and potential cost savings. These findings underscore the practicality of integrating ASCS in burn management, offering substantial benefits to patients and healthcare institutions.

EARLY ACTIVATION PATHWAYS IN PATIENTS UNDERGOING OPEN HEART SURGERY WITH MULTICOMPONENT GENERAL ANESTHESIA COMBINED WITH HIGH THORACIC EPIDURAL ANESTHESIA

Background: Early mobilization of patients in the postoperative period after open heart surgeries, significantly decreases the risk of complications, accelerates the restoration of functional capacity, shortens the length of hospital stay, and reduces treatment costs Materials and methods: Open heart surgeries were performed on 60 patients at Ankara "Bayındır" Hospital, Central Clinical Hospital, and Baku Health Center were included in the study. Patients were divided into two groups. 30 of them underwent the procedure with the use of multi-component balanced general anesthesia and intravenous fentanyl analgesia in the postoperative period. The other group of 30 patients underwent catheterization under high thoracic epidural anesthesia, with the administration of ropivacaine prior to induction and, in the postoperative period, ropivacaine and fentanyl. We conducted a study on central hemodynamic parameters and analgesic effects. Results: Thirty of them underwent the procedure with the use of multi-component general anesthesia and intravenous fentanyl analgesia in the postoperative period. The other group of 30 patients underwent catheterization of the high epidural space with the administration of ropivacaine before induction and, in the postoperative period, ropivacaine and fentanyl. We conducted a study on central hemodynamic parameters and analgesic effects. Conclusion: It has been established that for patients in the second group according to the Enhanced Recovery After Surgery strategy, hemodynamic support and effective pain management can contribute to early patient mobilization after surgery. Early mobilization, in turn, can expedite recovery and reduce the length of hospital stay, ultimately leading to potential cost savings.

Tariff option preferences for smart and bidirectional charging: Evidence from battery electric vehicle users in Germany

Smart charging of battery electric vehicles (BEVs) can contribute to flexibility in power grids and help integrate renewable electricity. Tapping into this potential requires high user acceptance for smart charging and corresponding tariffs. In this paper, we analyze the preferences of current BEV users, representing the potential near-term adopters of smart charging, for different smart charging tariff design elements by conducting a discrete choice experiment with 689 participants in Germany. In doing so, we (1) provide an overview of current BEV users' preferences, (2) identify and characterize BEV user groups with substantial differences in their preferences, and (3) identify barriers for smart charging implementation from the perspective of current BEV users. More specifically, we find that potential cost savings along with the pricing scheme and charging mode are the most important tariff elements, whereof a pre-defined price corridor with an emergency price for grid bottlenecks and charging a safety buffer before applying smart charging are most preferred. We identify three user groups, with a large share of innovative adopters. Moreover, driving range or reluctance regarding data sharing can represent barriers for smart charging adoption. Based on our findings, we derive implications for decision-makers in policy and industry.

Clinical implementation of artificial-intelligence-assisted detection of breast cancer metastases in sentinel lymph nodes: the CONFIDENT-B single-center, non-randomized clinical trial

Pathologists’ assessment of sentinel lymph nodes (SNs) for breast cancer (BC) metastases is a treatment-guiding yet labor-intensive and costly task because of the performance of immunohistochemistry (IHC) in morphologically negative cases. This non-randomized, single-center clinical trial (International Standard Randomized Controlled Trial Number:14323711) assessed the efficacy of an artificial intelligence (AI)-assisted workflow for detecting BC metastases in SNs while maintaining diagnostic safety standards. From September 2022 to May 2023, 190 SN specimens were consecutively enrolled and allocated biweekly to the intervention arm (n = 100) or control arm (n = 90). In both arms, digital whole-slide images of hematoxylin–eosin sections of SN specimens were assessed by an expert pathologist, who was assisted by the ‘Metastasis Detection’ app (Visiopharm) in the intervention arm. Our primary endpoint showed a significantly reduced adjusted relative risk of IHC use (0.680, 95% confidence interval: 0.347–0.878) for AI-assisted pathologists, with subsequent cost savings of ~3,000 €. Secondary endpoints showed significant time reductions and up to 30% improved sensitivity for AI-assisted pathologists. This trial demonstrates the safety and potential for cost and time savings of AI assistance.

Lower Associated Risk of Revision With All-Polyethylene Tibial Components in Total Knee Arthroplasty: An Analysis of the American Joint Replacement Registry

BackgroundDespite the potential advantage of all-polyethylene tibial components, modular metal-backed component use predominates the market in the United States for total knee arthroplasty (TKA). This is partially driven by concerns about the associated revision risk due to the lack of modularity with all-polyethylene components. This study utilized the American Joint Replacement Registry to compare the associated risk of all-cause revision and revision for infection for all-polyethylene versus modular metal-backed tibial components. MethodsAn analysis of primary TKA cases in patients aged 65 years and older was performed with American Joint Replacement Registry data linked to Centers for Medicare and Medicaid Services data from 2012 to 2019. Analyses compared all-polyethylene to modular metal-backed tibial components. We identified 485,024 primary TKA cases, consisting of 479,465 (98.9%) metal-backed and 5,559 (1.1%) all-polyethylene. Cox proportional hazard regression analyses created hazard ratios (HRs) to evaluate the association of design and the risk of all-cause revision while adjusting for sex, age, and the competing risk of mortality. Event-free survival curves evaluate time to revision. ResultsThe all-polyethylene tibia group demonstrated a decreased risk for all-cause revision (HR = 0.37; 95% confidence interval: 0.24 to 0.55; P < .0001) and revision for infection (HR = 0.41; 95% confidence interval: 0.22 to 0.77, P < .0001). Event-free survival curves demonstrated a decreased risk of all-cause revision that persisted across time points until 8 years post-TKA. ConclusionsIn the United States, all-polyethylene tibial component use for TKA remains low compared to modular metal-backed designs. A decreased associated risk for revision should ease concerns about the use of all-polyethylene components in patients aged 65 years or older, and future investigations should investigate the potential cost and value savings associated with expanded use in this population. Level of EvidenceTherapeutic Level III.

Advantages and Challenges of Platform Trials for Disease Modifying Therapies in Parkinson's Disease.

Traditional drug development in Parkinson's disease (PD) faces significant challenges because of its protracted timeline and high costs. In response, innovative master protocols are emerging and designed to address multiple research questions within a single overarching protocol. These trials may offer advantages such as increased efficiency, agility in adding new treatment arms, and potential cost savings. However, they also present organizational, methodological, funding, regulatory, and sponsorship challenges. We review the potential of master protocols, focusing on platform trials, for disease modifying therapies in PD. These trials share a common control group and allow for the termination or addition of treatment arms during a trial with non-predetermined end. Specific issues exist for a platform trial in the PD field considering the heterogeneity of patients in terms of phenotype, genotype and staging, the confounding effects of symptomatic treatments, and the choice of outcome measures with no consensus on a non-clinical biomarker to serve as a surrogate and the slowness of PD progression. We illustrate these aspects using the examples of the main PD platform trials currently in development with each one targeting distinct goals, populations, and outcomes. Overall, platform trials hold promise in expediting the evaluation of potential therapies for PD. However, it remains to be proven whether these theoretical benefits will translate into increased production of high-quality trial data. Success also depends on the willingness of pharmaceutical companies to engage in such trials and whether this approach will ultimately hasten the identification and licensing of effective disease-modifying drugs. © 2024 International Parkinson and Movement Disorder Society.

Enabling IP-optical integration in core and metro networks [Invited

IP-optical (Internet protocol and optical) integration, or “IP over DWDM (dense wavelength division multiplexing),” is a concept spanning over two decades since the advent of coherent DSP (digital signal processing). In recent years, coherent DSP technology has progressed to a point where it can be integrated on small pluggable form factors that can be equipped in optical line systems and disaggregated transponders or directly in IP routers to support a range of metro and core applications. The option of equipping pluggable digital coherent optics (DCOs) directly in IP routers has the biggest potential for operational cost savings but hinges on the availability of a unified management environment with a single pane of glass to coordinate and automate IP routing and optical transport functions. This work presents alternative software-defined networking (SDN) architectures and evaluates the challenges associated with the evolution to IP over DWDM network architectures. It demonstrates the first, to our knowledge, implementation of the Transport API supporting colored pluggable interfaces in routers in a real network testbed. This work contributes to the realization of end-to-end network management for IP-optical networks, offering operators comprehensive visibility into multi-layer and multi-domain services and empowering revenue generation.

Man versus machine: cost and carbon emission savings of 4G-connected Artificial Intelligence technology for classifying species in camera trap images

Timely and accurate detection and identification of species are crucial for monitoring wildlife for conservation and management. Technological advances, including connectivity of camera traps to mobile phone networks and artificial intelligence (AI) algorithms for automated species identification, can potentially improve the timeliness and accuracy of species detection and identification. Adoption of this new technology, however, is often seen as cost-prohibitive as it has been difficult to calculate the cost savings or qualitative benefits over the life of the program. We developed a decision tool to quantify potential cost savings associated with incorporating the use of mobile phone network connectivity and AI technologies into monitoring programs. Using a feral cat eradication program as a case study, we used our decision tool to quantify technology-related savings in costs and carbon emissions, and compared the accuracy of AI species identification to that of experienced human observers. Over the life of the program, AI technology yielded cost savings of $0.27 M and when coupled with mobile phone network connectivity, AI saved $2.15 M and 115,838 kg in carbon emissions, with AI algorithms outperforming human observers in both speed and accuracy. Our case study demonstrates how advanced technologies can improve accuracy and cost-effectiveness and improve monitoring program efficiencies.

Flexible copper: Exploring capacity-based energy demand flexibility in the industry

Different forms of flexibility can help in balancing variable generation. This work focuses on industrial demand-side flexibility applied in copper production, which is expected to grow for the build-out of green technologies.This study assesses the potential of capacity-based energy demand flexibility (over-sizing production processes) in an industry embedded in fully renewable energy systems. For this, an optimization model for multi-vector energy systems planning is extended so that it also includes the sizing and operation of a production process. A case study is presented for copper production, with greenfield results until 2050.Results show that flexibility at the concentration and refining stages belongs to the cost-optimal system design, at least over the next decade. At current costs, the potential cost savings in the energy system for the production process through capacity-based demand flexibility range from 5 % to 12 %, depending on the technology scenario. These potential savings are expected to decrease over time if cost reductions of renewable energy supply and storage technologies materialize. Technology scenarios considering seawater pumped-hydro energy storage yield lower costs over the entire projected period.

Mechanical and Electrochemical Implications of Drying Temperature on Lithium‐Ion Battery Electrodes

AbstractLithium‐ion battery (LIB) electrodes are typically produced with n‐methyl‐2‐pyrrolidone, a toxic solvent that is a known carcinogen and reproductive hazard. Accordingly, aqueous processing has been an expanding area of research interest in the field of LIB manufacturing. Although aqueous processing has been widely successful in anode processing, serious challenges remain in processing the cathode. In this work, the drying mechanics of cathode processed with both solvents is investigated though implementation of a chemical‐engineering‐based model to better understand the utilization of heat provided by experimentally determining the heat and mass transfer coefficients. Electrochemical performance is also evaluated to determine the impact of drying temperature on cycling performance. Binder distribution is determined via various methods to confirm differences in binder homogeneity as a function of both solvent and drying temperature. Identified is the large difference in the efficiency in which the heat is used as well as an ideal drying temperature for both aqueous and non‐aqueous processed cathodes. Also identified is the increased sensitivity to processing temperature for aqueous processed electrodes compared to non‐aqueous processed counterparts, pointing to the possibility of tuned drying regimes which would capitalize on the potential cost savings of aqueous processing for cathodes.

Sustainable Innovation in Ceiling: Exploring the Environmental Benefits of a New Plaster–Rock Wool Layered Recycled Composite

This paper presents a new layered plaster-based material for building purposes. First, a new manufacturing machine was designed to make the elaboration process easier. This manufacturing machine and the way it works are described. In this study, perlite and recycled glass wool (RGW) were added to traditional plaster with the aim of improving the performance of this material. Two series (with and without perlite) and three different layer configurations were developed and assessed. Recycled glass wool layered materials were subjected to both physical and mechanical characterisation to determine their suitability for precast elaboration. The addition of perlite resulted in a significant improvement in flexural strength. Moreover, the addition of RGW also gave rise to extra flexural strength when added. The two-layered samples performed better than the one-layered samples. Mechanical properties increased up to 75% when both the perlite and RGW layers were added. Potential Global Warming Potential (GWP 100) savings were also analysed, reporting up to 49% savings. A complementary cost analysis was performed, aimed at establishing potential savings in production costs; thus, 13–57% potential cost savings were reported. After that, a comparative analysis within the literature was conducted to contextualise the results obtained in this study.

Metrics to quantify the degree of co-location of urban water infrastructure.

Co-located infrastructure networks such as road, water, and sewer in theory offer the possibility for integrated multi-infrastructure interventions. However, how closely these networks are aligned in space and time determines the practical extent to which such coordinated interventions can be realized. This study quantifies the spatial alignment of the aforementioned infrastructure networks and demonstrates its application for integrated interventions and potential cost savings. It proposes two metrics, namely 1) shared surface area and, 2) shared trench volume, to quantify the spatial relationship (i.e., degree of co-location) of infrastructures. Furthermore, the study demonstrates how the degree of co-location can be used as a proxy for cost-saving potential of integrated interventions compared to silo-based, single-infrastructure, interventions. Through six case studies conducted in Norwegian municipalities, the research reveals that implementing integrated interventions across road, water, and sewer networks can result in potential average cost savings of 24% in urban areas and 11% in rural areas. Utility-specific savings under different cost-sharing scenarios were also analysed. To identify the yearly potential of integrated multi-infrastructure interventions, future work should add the temporal alignment of rehabilitation of infrastructures (i.e., time of intervention need for the infrastructures).

Management of excavated soil and dredging spoil waste from construction and demolition within the EU: Practices, impacts and perspectives

Excavated soil and rock (ESR) and dredging spoils (DDS) account for 23 % of the total EU waste generation in 2020. This study performs a life cycle assessment and life cycle costing to quantify the potential environmental and cost savings resulting from increasing the level of ESR and DDS prepared for reuse and recycled in comparison to the business-as-usual practice. Scenarios for the waste management pathways based on the status quo, technical feasibility or normative impositions are assessed, including the potential contribution to achieving the European Green Deal goals. Results show that promoting preparing for reuse and recycling could lead to non-negligible GHG reductions (up to 3.6 Mt. CO2 eq.) and economic savings (EUR 12.3 billion) annually. Depending upon the scenario, 0.2 % to 1 % of the net annual GHG emissions reductions sought by the European Green Deal could be facilitated by scaling up improved circular management of ESR and DDS at the EU level. Finally, the study highlights the main barriers to scaling up to more circular (i.e., preparing for reuse and recycling) and better performing management options in Europe. The results provide new insights for the European Green Deal and circular economy policymaking for CDW.

A Review Delving into the Factors Influencing Mycelium-Based Green Composites (MBCs) Production and Their Properties for Long-Term Sustainability Targets.

Mycelium-based green composites (MBCs) represent an eco-friendly material innovation with vast potential across diverse applications. This paper provides a thorough review of the factors influencing the production and properties of MBCs, with a particular focus on interdisciplinary collaboration and long-term sustainability goals. It delves into critical aspects such as fungal species selection, substrate type selection, substrate preparation, optimal conditions, dehydrating methods, post-processing techniques, mold design, sterilization processes, cost comparison, key recommendations, and other necessary factors. Regarding fungal species selection, the paper highlights the significance of considering factors like mycelium species, decay type, hyphal network systems, growth rate, and bonding properties in ensuring the safety and suitability of MBCs fabrication. Substrate type selection is discussed, emphasizing the importance of chemical characteristics such as cellulose, hemicellulose, lignin content, pH, organic carbon, total nitrogen, and the C: N ratio in determining mycelium growth and MBC properties. Substrate preparation methods, optimal growth conditions, and post-processing techniques are thoroughly examined, along with their impacts on MBCs quality and performance. Moreover, the paper discusses the importance of designing molds and implementing effective sterilization processes to ensure clean environments for mycelium growth. It also evaluates the costs associated with MBCs production compared to traditional materials, highlighting potential cost savings and economic advantages. Additionally, the paper provides key recommendations and precautions for improving MBC properties, including addressing fungal strain degeneration, encouraging research collaboration, establishing biosecurity protocols, ensuring regulatory compliance, optimizing storage conditions, implementing waste management practices, conducting life cycle assessments, and suggesting parameters for desirable MBC properties. Overall, this review offers valuable insights into the complex interplay of factors influencing MBCs production and provides guidance for optimizing processes to achieve sustainable, high-quality composites for diverse applications.

Comparison of zanubrutinib (zanu) and acalabrutinib (acala) in B-cell malignancies: An adverse event (AE)-based analysis.

e19049 Background: Acala and zanu are 2nd generation Bruton tyrosine kinase inhibitors (BTKis) that have demonstrated improved safety profiles vs 1st generation BTKi ibrutinib in clinical trials. While head-to-head comparison of zanu vs acala is lacking, a recent meta-analysis of clinical trials provided a comprehensive, indirect comparison of the AE profiles in B-cell malignancies (Hwang, Hemasphere. 2023;7(S3):1134). This study aims to evaluate costs and impacts on quality of life (QoL) for zanu vs acala using their AE profiles. Methods: A health economic model was developed to determine cost and QoL associated with AE management for zanu and acala. The incidence rates ( IRs) of all grade and grade ≥3 AEs of interest (n=21, including bleeding events, hypertension, atrial fibrillation, cytopenias, infections, headache, arthralgia, diarrhea) were taken from the meta-analysis. Additional model inputs, such as disutility, average duration of AE, and unit cost of each AE were sourced from published literature and publicly available cost databases in consultation with clinical experts. The model was developed from the US perspective, considering Medicare costs, inflated to 2023 USD. Model outcomes were AE management cost (= IR * unit cost) and quality-adjusted life years (QALYs) lost due to AE (= IR * Disutility * Duration/365.25). Results: In the base-case scenario (considering all AEs), treating a hypothetical cohort of 1000 patients (pts) with zanu instead of acala yielded cost savings of $124K and 3.7 QALY gains (i.e., 3.7 years extra in full health). Subgroup analysis for severe (grade ≥3) and non-severe AEs (grade 1-2) demonstrated similar trends. A sensitivity analysis limited to AEs significantly different between zanu and acala (n=13) yielded consistent results. Additionally, a probabilistic sensitivity analysis, conducted with 1000 iterations to account for uncertainty in model parameters, confirmed robustness of the model, indicating stable conclusions across a wide range of parameter uncertainties. Conclusions: This analysis suggested that zanu is cost-saving and associated with added health benefits compared to acala in terms of AE management in pts with B-cell malignancies. Should these results derived from meta-analysis of clinical trial data be applicable to real-world pt populations across different indications, the potential cost savings could be considerable. These results could be further improved if the differences in efficacy of zanu vs acala are also incorporated. [Table: see text]