Potential Benefits Research Articles

Robotic Process Automation in Artificial Intelligence

This paper explores the symbiotic relationship between Robotic Process Automation (RPA) and Artificial Intelligence (AI) and their collective impact on streamlining and optimizing various business processes. We delve into the integration of AI technologies, such as machine learning and natural language processing, with Robotic Process Automation to create intelligent automation solutions. Furthermore, it examines how the infusion of Artificial Intelligence into RPA empowers systems to adapt and learn, fostering adaptability and agility within organizations. The abstract concludes by highlighting the potential benefits, challenges, and future prospects of this amalgamation, emphasizing the transformative impact on businesses in the era of intelligent automation.

Striding Toward Cardiovascular Health: The Impact of Step Counts on Heart Wellness.

In an era characterized by sedentary lifestyles, cardiovascular diseases pose a significant global health challenge. As preventive healthcare strategies evolve, this article explores the tangible and accessible metric of step counts and their implications for cardiovascular health. The review provides insights into potential benefits, challenges, and future directions in promoting physical activity for heart wellness.

Individuals' experiences in genetic counseling and predictive testing for familial amyotrophic lateral sclerosis.

As clinical genetic testing in the amyotrophic lateral sclerosis (ALS) diagnostic setting increases, the identification of at-risk family members has also expanded. No practice guidelines specifically for predictive genetic testing exist, and few studies about the psychological impacts of testing in this subgroup have occurred, limiting the ability to tailor recommendations and counseling in this community. We surveyed asymptomatic individuals at risk for inheriting an ALS-associated gene mutation. The 80-question survey was designed using a combination of validated measures (General Anxiety Disorder; FACToR; Decision Regret Scale) and original items. Ninety participants completed the survey, including those who completed predictive genetic testing (N = 42) and those who did not (N = 48). Gene positive individuals experienced greater negativity, uncertainty, and overall psychological impairment (p = 0.002; p < 0.001; p = 0.001). Individuals who had not undergone testing reported thinking about their risk multiple times per day and experiencing more decisional regret than those who tested (p = 0.006). In terms of decision-making, being prepared for potential clinical drug trials was a more important potential benefit among those who underwent testing (p = 0.026). Participants valuing preparedness for clinical drug trials supports the concept that genetic testing for ALS will increase as research in gene-targeted therapeutics progresses. This study describes factors relevant to the genetic testing decision-making process and adaptation to results from the perspective of at-risk individuals, which can ultimately guide genetic counseling practice in this population.

Examining the Morphology of External Genitalia in Iranian Women: A Labiagram-based Study in Iran and its Influence on Patients' Self-Satisfaction.

This study aims to document a woman's external genitalia data in the form of a labiogram and investigate whether variations in the size of specific components of a woman's external genitalia can influence her overall satisfaction with the esthetic appearance of her genitalia. A cross-sectional observational study was carried out on a sample of 500 Iranian women. Socio-demographic information was collected for all participants, and they completed the Female Genital Self-Image Scale (FGSIS) questionnaire. Measurements of different external genitalia components were obtained for all participants. The findings revealed that there was no significant association between the measurements of the external genitalia and age or BMI. However, a significant negative correlation was observed between the total score on the FGSIS and specific parameters related to the width of different sections of the labia minora. The correlations were as follows: left lower third (r = -0.305), lower right third (r = -0.302), left middle third (r = -0.365), right middle third (r = -0.435), left upper third (r = -0.397), and right upper third (r = -0.407) (P value< 0.001). Moreover, cutoff points of 1.95cm on the left side and 1.90cm on the right side were identified through analysis as thresholds for predicting dissatisfaction among women. This study suggests that the width of the labia minora might influence certain women's motivation to undergo labiaplasty, a surgical procedure designed to modify the labia minora. To help women make informed decisions, it is crucial for those considering the procedure to have a comprehensive understanding of different labia minora types, potential benefits, and associated risks. By being well-informed, individuals can make choices that align with their personal preferences and priorities. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Solar Chimney Power Plants for Sustainable Air Quality Management Integrating Photocatalysis and Particulate Filtration: A Comprehensive Review

Urban air pollution has become a pressing challenge in recent times, demanding innovative solutions. This review delves into the potential of Solar Chimney Power Plants (SCPPs) as a sustainable approach to mitigating air pollution. The idea of mitigation of pollution may be an added advantage to the use of SCPPs in practice. Recent advancements, such as the integration of photocatalytic reactors (PCRs) for the elimination of greenhouse gases (GHGs), emphasizing the importance of addressing non-CO2 GHGs like CH4 and N2O are analyzed. The novelty of this review is that it not only focuses on the shifting and removal of particulate matter but also on the removal of greenhouse gases. Numerous case studies, ranging from filter-equipped SCPPs to Solar-Assisted Large-Scale Cleaning Systems (SALSCSs), are reviewed, providing a comprehensive understanding of their design, performance, and potential benefits. This review serves as a guide for researchers and policymakers, emphasizing the need for multifaceted approaches to address the intricate nexus of air pollution, renewable energy generation, and climate change mitigation.

Exosomes Derived from Mouse Breast Carcinoma Cells Facilitate Diabetic Wound Healing.

Exosomes derived from breast cancer have been reported to play a role in promoting cell proliferation, migration, and angiogenesis, which has the potential to accelerate the healing process of diabetic wounds. The aim of this investigation was to examine the function of exosomes originating from 4T1 mouse breast carcinoma cells (TEXs) in the process of diabetic wound healing. The assessment of primary mouse skin fibroblastscell proliferation and migration was conducted through the utilization of CCK-8 and wound healing assays, while the tube formation of HUVECs was evaluated by tube formation assay. High-throughput sequencing, RT-qPCR and cell experimentswere used to detect the roles ofmiR-126a-3pin HUVECsfunctions in vitro. The in vivo study employed a model of full-thickness excisional wounds in diabetic subjects to explore the potential therapeutic benefits of TEXs. Immunohistochemical and immunofluorescent techniques were utilized to evaluate histological changes in skin tissues. The findings suggested that TEXs facilitate diabetic wound healing through the activation of cell migration, proliferation, and angiogenesis. An upregulation of miR-126a-3p has been observed in TEXs, and it has demonstrated efficient transferability from 4T1 cells to HUVEC cells. The activation of the PI3K/Akt pathway has been attributed to miR-126a-3p derived from TEXs. The promotion of chronic wound healing can be facilitated by TEXs through the activation of cellular migration, proliferation, and angiogenesis. The activation of the PI3K/Akt pathway by miR-126a-3p originating from TEXs has been discovered, indicating a potential avenue for enhancing the regenerative capabilities of wounds treated with TEXs.

Rotational fishery closures could enhance coral recovery in systems with alternative states

AbstractRotational closures have potential fisheries benefits, yet their impact on coral cover is unknown. Research has shown that permanent closures can protect herbivorous fish, indirectly benefiting corals, but these observations may not apply when closed periods alternate with fishing. Here, we examine how rotational closures affect coral, focusing on systems with the potential to switch between alternative stable states, a context in which temporary closures may have persistent effects. We show that rotational closures can trigger coral recovery, and in some contexts lead to better coral recovery than fixed closures of similar size. Such benthic effects are only possible if closures last long enough for change to occur. We also note that very large fixed or rotating closures may concentrate fishing effort in areas where fishing remains permitted, leading to lower overall coral cover. Our findings offer crucial guidance to managers regarding rotational closures’ potential advantages and drawbacks.

Potential role of cannabis in ameliorating observed racialized disparities in cancer pain management.

Cancer-related pain affects a large proportion of all patients with cancer yet remains inadequately managed, particularly among patients from certain racialized backgrounds. Recently, there has been increased research and clinical interest in the use of medical cannabis for cancer pain management, including its potential to ameliorate race-based disparities in cancer pain control. Although medical cannabis is not currently a US Food and Drug Administration-approved treatment option for cancer-related pain, many oncologists discuss and recommend its use with their patients, underscoring the need for researchers and clinicians to proactively identify barriers to cannabis for cancer pain management that may disproportionately affect patients from certain racial groups. In this commentary, we highlight challenges that patients from racialized backgrounds may face when incorporating cannabis into their palliative care regimens and discuss opportunities for researchers and clinicians to address these challenges should medical cannabis become a recommended treatment option for cancer pain management. In particular, we identify challenges at the structural (eg, lack of insurance coverage), clinician (eg, racialized stereotypes regarding addiction and pain), and individual (eg, internalized stigma) levels and emphasize the importance of multilevel approaches in combating these challenges as the evidence base regarding medical cannabis and its potential harms and therapeutic benefits continues to accumulate.

Molecular, Crystalline, and Microstructures of Lipids from Astrocaryum Species in Guyana and Their Thermal and Flow Behavior

The phase behavior of lipids extracted from Astrocaryum vulgare (AV) and Astrocaryum aculeatum (AA) pulp and kernels and their microstructural, thermal and flow properties were studied. The lipid profiles, crystal structures, microstructures, thermal stabilities and flow behaviors of these lipids provided important structure–function information that are useful to assess potential applications in the food, cosmetic and pharmaceutical industries. AV and AA fruits were sourced from the lowlands and rainforests, respectively, of Guyana. AV and AA pulp oils (AVP and AAP) were distinguished from each other in composition and unsaturation, with AVP oils being predominated by a di-unsaturated TAG (2-(palmitoyloxy)propane-1,3-diyl dioleate (POO)) and AAP oils predominated by propane-1,2,3-triyl trioleate (OOO); there were unsaturation levels of 65% and 80%, respectively. The main fatty acids in AVP oils were oleic, palmitic and stearic; for AAP, these were oleic, linoleic, palmitic and stearic. The kernel fats of AV and AA were similar in composition and had saturation levels of 80%, being mainly comprised of tri-saturated TAGs propane-1,2,3-triyl tridodecanoate (LLL) and 3-(tetradecanoyloxy)propane-1,2-diyl didodecanoate (LML). The onset of mass loss (T5%on) of AV and AA pulp oils were similar at 328 ± 6 °C, which were 31 °C ± 9 higher compared to that of the kernel fats, which demonstrated similar T5%on = 293 ± 7 °C. AA and AV pulp oils were liquid at room temperature, with melting points of −5 ± 1 °C and 3 ± 1 °C, respectively; both kernel fats were solid at room temperature, packing in β′ (90% of crystals) and β (10% of crystals) polymorphic forms and melting almost identically at 30 ± 1 °C. Pulp oils demonstrated sporadic nucleation at the onset of crystallization with slow growth into rod-shaped crystallites, leading to an approximately 50% degree of crystallization at undercooling of approximately 40K. Nucleation for kernel fats was instantaneous at undercooling of approximately 23K, demonstrating a spherulitic growth pattern incorporating crystalline lamella and a 90% degree of crystallization. Kernel fats and pulp oils demonstrated Newtonian flow behavior and similar dynamic viscosity in the melt, approximately 28.5 mPa·s at 40 °C. The lipid profiles of AVP and AAP oils were dominated by unsaturated TAGs, suggesting potential nutrition and health benefits, particularly compared to other tropical oils with higher saturation levels, such as palm oil. AAP oil in particular is as unsaturated as olive oil, contains high levels of beta carotene and provides a unique flavor profile. The AAK and AVK lipid profiles and phase transformation indicate potential for applications where a high solid fat content and medium-chain fatty acids are required. Their high lauric and myristic acid content makes them similar to industrially important tropical oils (coconut and palm kernel), suggesting their use in similar formulations. The melting point and plasticity of the kernel fats are similar to that of cocoa and shea butters, suggesting use as replacements in cosmetics, foods and confections. There is, however, the need to better understand their nutritional status and effects on health.

The Role of the IBSA Fund in Foreign Aid Policies of IBSA and BRICS Member States

The IBSA Fund, which marks its 20th anniversary in 2024, has extended SouthSouth cooperation to 34 states since its establishment in 2004. This article aims to compare the recipients of bilateral development assistance from IBSA members with IBSA Fund projects’ partners. The objective is to discern the motivations behind the selection of the Fund’s project partners, assess the influence of member states on partner selection, and explore the potential benefits of including Russia and China (both BRICS and New Development Bank participants) as members. The authors analyze the structure, mechanisms, and priorities of IBSA projects, juxtaposing them with New Development Bank projects to highlight key differences and assess shortcomings. The research draws on releases and reports from development agencies, AidData databases, and online databases detailing cooperation projects of all IBSA members and the IBSA Fund. The analysis reveals that the IBSA Fund serves as an additional tool for member states in development cooperation, driven by shared opportunities and responsibilities. Partner selection appears largely motivated by the national interests of IBSA states. While both the IBSA Fund and New Development Bank espouse similar development principles, goals, and narratives, they exhibit differences in terms of development cooperation modalities, emphasis on loans versus grants, project geography, and priorities. As this makes closer cooperation between the two entities unreasonable, Russia and China, whose development assistance priorities largely align with those of the IBSA members, could still be included in the IBSA Fund mechanism, particularly if additional funding is required.

The Difference Between Cystatin C- and Creatinine-Based Estimated Glomerular Filtration Rate and Risk of Diabetic Microvascular Complications Among Adults With Diabetes: A Population-Based Cohort Study.

The impact of the difference between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFRdiff) on diabetic microvascular complications (DMCs) remains unknown. We investigated the associations of eGFRdiff with overall DMCs and subtypes, including diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic neuropathy (DN). This prospective cohort study included 25,825 participants with diabetes free of DMCs at baseline (2006 to 2010) from the UK Biobank. eGFRdiff was calculated using both absolute difference (eGFRabdiff) and the ratio (eGFRrediff) between cystatin C- and creatinine-based calculations. Incidence of DMCs was ascertained using electronic health records. Cox proportional hazards regression models were used to evaluate the associations of eGFRdiff with overall DMCs and subtypes. During a median follow-up of 13.6 years, DMCs developed in 5,753 participants, including 2,752 cases of DR, 3,203 of DKD, and 1,149 of DN. Each SD decrease of eGFRabdiff was associated with a 28% higher risk of overall DMCs, 14% higher risk of DR, 56% higher risk of DKD, and 29% higher risk of DN. For each 10% decrease in eGFRrediff, the corresponding hazard ratios (95% CIs) were 1.16 (1.14, 1.18) for overall DMCs, 1.08 (1.05, 1.11) for DR, 1.29 (1.26, 1.33) for DKD, and 1.17 (1.12, 1.22) for DN. The magnitude of associations was not materially altered in any of the sensitivity analyses. Large eGFRdiff was independently associated with risk of DMCs and its subtypes. Our findings suggested monitoring eGFRdiff in the diabetes population has potential benefit for identification of high-risk patients.

Eyelash serums: A comprehensive review.

Eyelash serums, both prescription and over-the-counter, are gaining popularity for enhancing the appearance of eyelashes through various biologically active molecules. Categorized into prostaglandin analogs and non-prostaglandin analogs, these serums claim increased strength, length, luster, and thickness. Current United States law also requires no efficacy or safety assessments by the Food and Drug Administration before approving products for consumer use, potentially posing health risks for patients seeking over-the-counter eyelash enhancements. Our aims include exploring proposed benefits and adverse effects associated with eyelash serums, while providing evidence-based clinical recommendations on their use. We aim to contribute valuable insights to the understanding of eyelash serums and their respective safety considerations. The authors conducted a comprehensive electronic search across databases including PubMed, Embase, Cochrane Central, and Google Scholar to evaluate eyelash serum ingredients. Articles were evaluated by two independent researchers for relevance, and the ingredients discussed were analyzed and given clinical recommendations for eyelash serums based off the Oxford Centre for Evidence-Based Medicine. Results highlight bimatoprost's efficacy, supported by numerous studies evaluating safety and adverse effects. Other prostaglandin ingredients show potential benefits, but further studies are encouraged to enhance the understanding of respective safety profiles. While non-prostaglandins ingredients show promising data, more studies are needed due to a lack of formal evidence in eyelash serum use. As the cosmeceutical market for eyelash serums is growing, dermatologists need to be knowledgeable about evidence-based information regarding prescription and over-the-counter eyelash serum products before making recommendations to patients.

Patient interest in and clinician reservations on polygenic embryo screening: a qualitative study of stakeholder perspectives.

We explored and compared perspectives of reproductive endocrinology and infertility specialists (REIs) and in vitro fertilization (IVF) patients regarding polygenic embryo screening (PES), a new type of preimplantation screening that estimates the genetic chances of developing polygenic conditions and traits in the future. Qualitative thematic analysis of semi-structured interviews with US-based REIs and IVF patients. Clinicians and patients often held favorable views of screening embryos for physical or psychiatric conditions, though clinicians tended to temper their positive attitudes with specific caveats. Clinicians also expressed negative views about screening embryos for traits more frequently than patients, who generally held more positive views. Most clinicians were either unwilling to discuss or offer PES to patients or were willing to do so only under certain circumstances, while many patients expressed interest in PES. Both stakeholder groups envisioned multiple potential benefits or uses of PES and raised multiple potential, interrelated concerns about PES. A gap exists between clinician and patient attitudes toward PES; clinicians generally maintained reservations about such screening and patients indicated interest in it. Clinicians and patients sometimes imagined using PES to prepare for the birth of a predisposed or "affected" individual-a rationale that is often associated with prenatal testing. Many clinicians and patients held different attitudes depending on what is specifically screened, despite the sometimes blurry distinction between conditions and traits. Considerations raised by clinicians and patients may help guide professional societies in developing guidelines to navigate the uncertain terrain of PES.

Strengthening the Downstream Supply Chain Management for Vaccines in the Philippines: Food and Drug Administration Perspective

The case study examines the framework established by the Food and Drug Administration Philippines to facilitate the Vaccine Supply Chain in the Philippines. During the pandemic, the said regulatory body must ensure its efficiency and safety. AnyLogistix, a system software employed in Post Market Surveillance for vaccines in Norway, was discovered during the research process. This software has facilitated the efficient assessment and monitoring of vaccines in Norway. Consequently, this case study explores the potential benefits of implementing anyLogistix in the Philippines to enhance drug and vaccine cold chain management. The Grounded Theory was used to assess the readiness and acceptance of local companies and organizations responsible for managing cold chain facilities and vaccines in the Philippines, to pave the way for future advancements in the field. Ultimately, the acceptability of the comparative study validates the approval of stakeholders, cold chain facilities, and government regulatory agencies in using anyLogistix as an automated system to efficiently monitor the post-market surveillance in the downstream stages of the supply chain for vaccines spearheaded by the Food and Drug Administration-Philippines. This study conducted a survey among 14 expert panelists both male and female in which 8 out of 14 panelists expressed dissatisfaction with the current system of how the government responds to pandemic outbreaks, 10 out of 14 panelists were not familiar with anyLogistix, and 11 out of 14 panelists shows interest in using this Norwegian software to improve the efficiency in responding to vaccine supply management issues, therefore, anyLogistix could be a good development that the Food and Drug Administration could utilize. Keywords: Strategic continuity, Business plan, Sustainability, Adaptability, Private Emission Testing Centers, Motor Vehicle Inspection System, Regulatory pressure, Leadership change, Policy shifts, Mixed methods research.

Cultivating Neurodiverse Connections Through Competent Leadership: Integrative Literature Review

This study examined the relationship between neurodiversity and leadership competency to create inclusive and encouraging settings. The concept of neurodiversity in the workplace stresses the acceptance and celebration of neurological variations, including autism, ADHD, and other neurodevelopmental disorders. In order to promote diversity, inclusion, and shape corporate culture, competent leadership is essential. In order to investigate how leaders might develop neurodiverse connections, this review synthesises the literature and looks at how they may embrace inclusive practices, recognise the special advantages and difficulties faced by neurodivergent people, and create a positive work environment. An extensive review of the present state of knowledge in this burgeoning topic is provided by the analysis, which includes studies from a variety of disciplines such as management, organisational behaviour, and psychology. The results underscore the significance of leadership competencies, including empathy, adaptability, and communication, in fostering settings that enable neurodivergent persons, hence augmenting creativity and efficiency. Furthermore, this study investigated the complex relationship between neurodiversity and leadership ability, with a particular emphasis on creating inclusive and supportive workplace settings. The findings highlight the importance of competent leadership in encouraging diversity, inclusiveness, and moulding corporate culture, particularly in terms of embracing neurodiverse relationships. As a result, this assessment suggests that leaders actively engage in inclusive practices, recognise the particular strengths and challenges that neurodivergent people confront, and help to create a pleasant work environment. Moving forward, it is believed that applying these recommendations will result in a more inclusive workplace culture, increasing acceptance and appreciation of neurological variances such as autism, ADHD, and other neurodevelopmental diseases. Organisations may empower neurodivergent individuals by building leadership abilities such as empathy, adaptability, and effective communication, resulting in increased creativity and efficiency. This study, which draws on a thorough evaluation of current knowledge from a variety of fields, is an invaluable resource for organisations looking to promote neurodiversity and capitalise on its potential benefits in the pursuit of a more inclusive and innovative workplace

Groups of Persons in the Proposed AI Act Amendments

Abstract This article explores the proposed amendments to the AI Act, which introduce the concept of “groups of persons”. The inclusion of this notion has the potential to broaden the traditional individual-centric approach in data protection. The analysis explores the context and the challenges posed by the rapid evolution of technology, with an emphasis on the role of artificial intelligence (AI) systems. It discusses both the potential benefits and challenges of recognising groups of people, including issues such as discrimination prevention, public trust and redress mechanisms. The analysis also identifies key challenges, including the lack of a clear definition for “group”, the difficulty in explaining AI architecture concerning groups and the need for well-defined redress mechanisms. The article also puts forward recommendations aimed at addressing these challenges in order to enhance the effectiveness and clarity of the proposed amendments.

Efficacy of brain-computer interfaces on upper extremity motor function rehabilitation after stroke: A systematic review and meta-analysis.

The recovery of upper limb function is crucial to the daily life activities of stroke patients. Brain-computer interface technology may have potential benefits in treating upper limb dysfunction. To systematically evaluate the efficacy of brain-computer interfaces (BCI) in the rehabilitation of upper limb motor function in stroke patients. Six databases up to July 2023 were reviewed according to the PRSIMA guidelines. Randomized controlled trials of BCI-based upper limb functional rehabilitation for stroke patients were selected for meta-analysis by pooling standardized mean difference (SMD) to summarize the evidence. The Cochrane risk of bias tool was used to assess the methodological quality of the included studies. Twenty-five studies were included. The studies showed that BCI had a small effect on the improvement of upper limb function after the intervention. In terms of total duration of training, < 12 hours of training may result in better rehabilitation, but training duration greater than 12 hours suggests a non significant therapeutic effect of BCI training. This meta-analysis suggests that BCI has a slight efficacy in improving upper limb function and has favorable long-term outcomes. In terms of total duration of training, < 12 hours of training may lead to better rehabilitation.

Closed-loop auditory stimulation of slow-wave sleep in chronic insomnia: a pilot study.

Insomnia is a prevalent and disabling condition whose treatment is not always effective. This pilot study explores the feasibility and effects of closed-loop auditory stimulation (CLAS) as a potential non-invasive intervention to improve sleep, its subjective quality, and memory consolidation in patients with insomnia. A total of 27 patients with chronic insomnia underwent a crossover, sham-controlled study with 2 nights of either CLAS or sham stimulation. Polysomnography was used to record sleep parameters, while questionnaires and a word-pair memory task were administered to assess subjective sleep quality and memory consolidation. The initial analyses included 17 patients who completed the study, met the inclusion criteria, and received CLAS. From those, 10 (58%) received only a small number of stimuli. In the remaining seven (41%) patients with sufficient CLAS, we evaluated the acute and whole-night effect on sleep. CLAS led to a significant immediate increase in slow oscillation (0.5-1 Hz) amplitude and activity, and reduced delta (1-4 Hz) and sigma/sleep spindle (12-15 Hz) activity during slow-wave sleep across the whole night. All these fundamental sleep rhythms are implicated in sleep-dependent memory consolidation. Yet, CLAS did not change sleep-dependent memory consolidation or sleep macrostructure characteristics, number of arousals, or subjective perception of sleep quality. Results showed CLAS to be feasible in patients with insomnia. However, a high variance in the efficacy of our automated stimulation approach suggests that further research is needed to optimise stimulation protocols to better unlock potential CLAS benefits for sleep structure and subjective sleep quality in such clinical settings.

Honey and Indian Costus as found in Prophetic Medicine and Pharmacognosy: A Creedal Comparison

This study examines the medical uses of both honey and Indian costus in prophetic medicine, as well as the modern studies conducted on them through pharmacological science. It then compares honey and the studies conducted on it in pharmacology on one hand, and Indian costus and the studies conducted on it in pharmacology on the other hand. The study concluded several important results, the most important of which is that most of the modern pharmacological studies included in this research align with the noble prophetic traditions regarding the models of honey and Indian costus. This indicates the potential benefit of these studies within the religious and doctrinal framework, to demonstrate the prophethood of our Prophet Muhammad, peace be upon him. As for the rest of the studies, they did not contradict his teachings, peace be upon him, but their evidence was speculative regarding the intended purpose, which does not make them independent evidence of the proof of prophethood; however, they can be used in conjunction with other evidence.

Probing the effect of perceptual (dis)fluency on metacognitive judgments.

Despite research showing that perceptually fluent stimuli (i.e., stimuli that are easier to process) are given higher judgment of learning (JOL) ratings than perceptually disfluent stimuli, it remains unknown whether the influence of perceptual fluency on JOLs is driven by the fluent or disfluent items. Moreover, it is unclear whether this difference hinges on relative differences in fluency. The current study addressed these unanswered questions by employing (Fiacconi et al., Journal of Experimental Psychology: Learning, Memory, and Cognition 46:926-944, 2020), Journal of Experimental Psychology: Learning, Memory, and Cognition, 46[5], 926-944) letter set priming procedure. In this procedure, participants are first exposed to words containing only a subset of letters. Following this exposure, JOLs to new words composed of the same letters (i.e., fluent), and new words composed of nonexposed letters (i.e., disfluent) are compared with isolate the contribution of perceptual fluency. Because this procedure does not rely on parametric variations in perceptual features, we can directly assess the potential benefit and/or cost of fluent and disfluent items, respectively, by including neutral baseline conditions. Moreover, implementing both a mixed- and pure-list design allowed us to assess the comparative nature of perceptual fluency on JOLs. Counter to previous assumptions, our results are the first to demonstrate that perceptual disfluency decreases JOLs. Moreover, we found that the influence of perceptual disfluency on JOLs hinges on the relative differences in fluency between items even in the absence of a belief about the mnemonic impact of the fluency manipulation. These findings have important implications as they provide evidence that the difficulty, rather than ease, of information form the basis of individuals metacognitive judgments.