Potential Antiradiation Agents Research Articles

ChemInform Abstract: S-(2-((2′-Carbamoylethyl)amino)ethyl) Phosphorothioate and Related Compounds as Potential Antiradiation Agents.

A reinvestigation of the radiation protection activity of S-(2-((2{prime}-carbamylethyl)amino)ethyl) lithium hydrogen phosphorothioate (4a) revealed that this compound possessed good (70% protection at a dose of 600 mg/kg) activity. The thione and imino bioisosteres of 4, S-(2-(2{prime}-thiocarbamylethylamino)ethyl) lithium hydrogen phosphorothioate (13a) and S-(2-(2{prime}-amidinoethylamino)ethyl) phosphorothioic acid (18b) showed 100% protection at doses of 300 and 150 mg/kg, respectively. The N-methyl (4b) and tert-butyl (4c) analogues of amide 4a, the N-methyl (13b) analogue of the thioamide 13a, the N-methyl (18a) analogue of amidine (18b), and the cyclic amidine S-(2-((2{prime}-(4,5-dihydroimidozoyl)ethyl)amino)ethyl) lithium hydrogen phosphorothioate (21) all showed 80% protection at the highest dose tested.

S-[2-[(2'-carbamoylethyl)amino]ethyl] phosphorothioate and related compounds as potential antiradiation agents

A reinvestigation of the radiation protection activity of S-[2-[(2'-carbamylethyl)amino]ethyl] lithium hydrogen phosphorothioate (4a) revealed that this compound possessed good (70% protection at a dose of 600 mg/kg) activity. The thione and imino bioisosteres of 4, S-[2-(2'-thiocarbamylethylamino)ethyl] lithium hydrogen phosphorothioate (13a) and S-[2-(2'-amidinoethylamino)ethyl] phosphorothioic acid (18b) showed 100% protection at doses of 300 and 150 mg/kg, respectively. The N-methyl (4b) and tert-butyl (4c) analogues of amide 4a, the N-methyl (13b) analogue of the thioamide 13a, the N-methyl (18a) analogue of amidine (18b), and the cyclic amidine S-[2-[[2'-(4,5-dihydroimidozoyl)ethyl]amino]ethyl] lithium hydrogen phosphorothioate (21) all showed 80% protection at the highest dose tested.

Activité radioprotectrice chez la Souris de composés thiazolidiniques dérivés de la cystéamine et de la mercapto-2 propylamine

2- and 2,5-substituted thiazolidine derivatives have been evaluated as potential anti-radiation agents in mice. Comparison with anti-radiation agent controls, shows the interest of this series: good activity at low doses ( LD 50 1 8 ), low toxicity and duration of the radioprotective effects varied according to the compound. Some thiazolidines are more active at low doses than the equimolecular quantity of cysteamine they release in vivo.

Synthesis of 4‐piperidazinethiols as potential antiradiation agents

AbstractThe free radical addition of thioacetic acid to 1,2‐dicarbethoxy‐1,2,3,6‐tetrahydropyridazines gave high yields of 1,2‐dicarbethoxy‐4‐S‐thiolacetoxypiperidazines. The latter compounds served as the key intermediates in the preparation of 4‐piperidazinethiols. The thiolacetoxy derivatives were partially hydrolyzed to afford the related 1,2‐dicarbethoxy‐4‐piperidazinethiols. Complete hydrolysis of the thiolacetates gave rise to 4‐piperidazinethiols. Finally, lithium aluminum hydride reduction of the thiolacetoxy esters produced a series of 1,2‐dimethyl‐4‐piperidazinethiols. Only 4‐piperidazinethiol hydrochloride showed appreciable anti‐radiation activity.

ChemInform Abstract: 1,2‐DIALKYL‐4‐PYRAZOLIDINETHIOLS AS POTENTIAL ANTIRADIATION AGENTS

Chemischer InformationsdienstVolume 11, Issue 10 Heterocyclic Compounds ChemInform Abstract: 1,2-DIALKYL-4-PYRAZOLIDINETHIOLS AS POTENTIAL ANTIRADIATION AGENTS M. J. KORNET, M. J. KORNETSearch for more papers by this authorR. DANIELS, R. DANIELSSearch for more papers by this author M. J. KORNET, M. J. KORNETSearch for more papers by this authorR. DANIELS, R. DANIELSSearch for more papers by this author First published: March 11, 1980 https://doi.org/10.1002/chin.198010242Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume11, Issue10March 11, 1980 RelatedInformation

1,2-Dialkyl-4-Pyrazolidinethiols as Potential Antiradiation Agents

The reaction between 3-chloropropylene sulfide and the 1,2-dialkylhydrazines was employed to prepare a series of 1,2-dialkyl-4-pyrazolidinethiols. Evidence is presented to support the structure proposed for the product. These mercaptoheterocycles are related to the β-mercaptoethylamines and were prepared as potential radiation protective agents. No significant activity was observed.

Terminal dicarboximido analogs of S-2-.omega.-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents. 2. Succinimides, glutarimides, and cis-1,2-cyclohexanedicarboximides

Terminal dicarboximido analogs of S-2-.omega.-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents. 2. Succinimides, glutarimides, and cis-1,2-cyclohexanedicarboximides

Terminal dicarboximido analogs of S-2-(omega-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents. 1. Phthalimides and saccharins.

Terminal dicarboximido analogs of S-2-(omega-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents. 1. Phthalimides and saccharins.

Alpha-amidrazonium thiosulfates as potential antiradiation agents.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.alpha.-Amidrazonium thiosulfates as potential antiradiation agentsTomas Lee Fridinger and Jerry Earl RobertsonCite this: J. Med. Chem. 1969, 12, 6, 1114–1115Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://doi.org/10.1021/jm00306a041RIGHTS & PERMISSIONSArticle Views33Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (265 KB) Get e-Alerts Get e-Alerts

Synthesis of Potential Antiradiation Agents. Part III. Some N-Alkyl-2 thiono-4-oxo-and 2, 4-Dithiono-1, 3-thiazane Derivatives

Synthesis of Potential Antiradiation Agents. Part III. Some N-Alkyl-2 thiono-4-oxo-and 2, 4-Dithiono-1, 3-thiazane Derivatives

3-(2-Mercaptoethylamino)propyl]oxamide and Related Compounds as Potential Antiradiation Agents

3-(2-Mercaptoethylamino)propyl]oxamide and Related Compounds as Potential Antiradiation Agents

S-[(N-Terpenoid carboxamidinium)methyl] thiosulfates (Bunte salts) as potential antiradiation agents

The synthesis of a number of α-acetamidinium Bunte salts, substituted on one of the nitrogen atoms by a terpenoid moiety, is reported.

Terminally substituted S-2-(omega-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents.

Terminally substituted S-2-(omega-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents.

S-2-(omega-aminoalkylamino)ethyl dihydrogen phosphorothioates and related compounds as potential antiradiation agents.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTS-[2-(.omega.-Aminoalkylamino)ethyl] dihydrogen phosphorothioates and related compounds as potential antiradiation agentsJames R. Piper, Carl R. Stringfellow Jr., Robert D. Elliott, and Thomas Patrick JohnstonCite this: J. Med. Chem. 1969, 12, 2, 236–243Publication Date (Print):March 1, 1969Publication History Published online1 May 2002Published inissue 1 March 1969https://doi.org/10.1021/jm00302a010RIGHTS & PERMISSIONSArticle Views388Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (887 KB) Get e-Alerts Get e-Alerts

Synthesis of potential antiradiation agents from 3-substituted 2-oxazolidinones derived from phenol, benzenethiol, and related compounds.

Synthesis of potential antiradiation agents from 3-substituted 2-oxazolidinones derived from phenol, benzenethiol, and related compounds.

S-2-aminethyl s'-omega-carboxyalkyl dithiocarbonate hydrochlorides as potential antiradiation agents.

S-2-aminethyl s'-omega-carboxyalkyl dithiocarbonate hydrochlorides as potential antiradiation agents.

The use of alpha-amino acids in the synthesis of derivatives of 2-aminoethanethiol as potential antiradiation agents.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Use of α-Amino Acids in the Synthesis of Derivatives of 2-Aminoethanethiol as Potential Antiradiation Agents1James R. Piper, Carl R. Stringfellow Jr., and Thomas P. JohnstonCite this: J. Med. Chem. 1966, 9, 6, 911–920Publication Date (Print):November 1, 1966Publication History Published online1 May 2002Published inissue 1 November 1966https://doi.org/10.1021/jm00324a027RIGHTS & PERMISSIONSArticle Views548Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts

Synthesis of Potential Antiradiation Agents. Part II. Some 1,3-Thiazane Derivatives

Synthesis of Potential Antiradiation Agents. Part II. Some 1,3-Thiazane Derivatives

Potential antiradiation agents. Preparation and polymerization of monomeric thiazolidines.

Potential antiradiation agents. Preparation and polymerization of monomeric thiazolidines.

Synthesis of amidine derivatives of alkylthiosulfuric acids as potential antiradiation agents

Abstract Two methods were used to prepare a series of amidine derivatives of alkylthiosulfuric acids to be used as potential antiradiation agents. In one method an equimolar mixture of an amidine and an aminothiosulfuric acid was reacted in boiling methanol to give the corresponding substituted N-(alkylthiosulfuric acid) amidine. In the other method an amidine was reacted with an aminoalkyl- thiosulfuric acid. The following compounds were prepared: