Potato early dying (PED) is characterized by a loss of plant vigor during mid to late summer followed by senescence and death of the crop a few weeks prior to normal maturity. This disease is of serious importance in areas of long-term or intensive potato production and is largely uncontrolled. Symptoms of PED, which are difficult to distinguish from normal senescence, especially in early-maturing cultivars, are uneven chlorosis and necrosis of vines and tan discoloration of vascular tissues. The basic cause of PED is the soil fungusVerticillium. Two species are involved—V. alboatrum predominating in cooler areas andV. dahliae in warmer areas. Both fungi commonly occur in cultivated soils and persist as melanized hyphae or microsclerotia, respectively. Infection occurs through roots followed by colonization of the vascular system. Contamination of uninfested fields can occur by wind or mechanical movement of soil-borne propagules or introduction of infested seed stock. AlthoughVerticillium is the primary pathogen in potato early dying, other soil organisms are involved, resulting in a “disease complex.” Research is under way in many areas to further our understanding of these pathogenic interactions and to exploit this knowledge for use in new systems of prediction and control.