In making measurements of exchangeable potassium in man, the dose usually employed is 250–350 μc of K 42. When mixing time is extended to 40 hr after injection of the tracer, accurate assay is difficult, even when using this dose. However, the advent of the plastic scintillator has made possible the construction of very sensitive well counters for β-detection. A new counter of this type is described, which counts K 42 at 15 per cent efficiency in liquid samples of 90 ml volume. Using this counter, measurements of exchangeable potassium can be made by using the specific activity of urine samples obtained 40 or more hr after administration of only 50 μc of K 42. Such urine samples usually have counting rates ranging from 1000 to 2000 counts per min above a background of 150 counts per min. Data are given showing the mixing of 50 μc of K 42 in a healthy man up to 60 hr after tracer administration. The values for exchangeable potassium in this man were computed on the basis of each of four urine samples voided later than 40 hr after injection. These four values for exchangeable potassium had a mean of 4181 m. equiv., with standard deviation 63 m. equiv.