Event Abstract Back to Event Invasive and non-invasive neuromodulation in movement disorders. Alain Maertens De Noordhout1* 1 University of Liege, University department of Neurology, Belgium In the last 25 years, invasive electrical stimulation (DBS) of several regions of the brain has been developed to alleviate symptoms of various movement disorders. Thalamic stimulation in severe essential tremor was first shown to provide long-term relief in many patients. A few years later, similar procedures have been successful in controlling major motor signs of Parkinson's disease with electrodes located in STN or GPi, and in severe dystonia with the latter target. Even dopa-resistant freezing of gait was reportedly reduced with high frequency stimulation of pedunculopontine nucleus. However, none of these interventions has so far proven any influence on the natural course of underlying illnesses. Yet, controlled studies have confirmed that DBS significantly improves QoL of patients, at least for some years. In neurodegenerative processes an particularly PD, it seems that QoL declines over years due to the lack of control of newly appearing symptoms such as dementia and postural disturbances. Non-invasive devices including rTMS and TDCS have also been used in such disorders but their effects remain debated and, even if sometimes positive, stay transient, thus needing repeated treaatment sessions. Lack of standardization of methods may account for some discrepancy of results. In coming years, it might be that restorative techniques using viral vectors could for the first time influence the natural course of illnesses such as Parkinson's disease. Keywords: DBS, rTMS, TCDS, Movement Disorders, Neuromodulation, neurorepair Conference: Belgian Brain Council 2014 MODULATING THE BRAIN: FACTS, FICTION, FUTURE, Ghent, Belgium, 4 Oct - 4 Oct, 2014. Presentation Type: Oral Presentation Topic: Clinical Neuroscience Citation: Maertens De Noordhout A (2014). Invasive and non-invasive neuromodulation in movement disorders.. Conference Abstract: Belgian Brain Council 2014 MODULATING THE BRAIN: FACTS, FICTION, FUTURE. doi: 10.3389/conf.fnhum.2014.214.00019 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jun 2014; Published Online: 30 Jun 2014. * Correspondence: Prof. Alain Maertens De Noordhout, University of Liege, University department of Neurology, Liege, B-4000, Belgium, al.maertens@chu.ulg.ac.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Alain Maertens De Noordhout Google Alain Maertens De Noordhout Google Scholar Alain Maertens De Noordhout PubMed Alain Maertens De Noordhout Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.