The study was designed to determine the pathological changes in postpartum Yankasa ewes experimentally infected with Trypanosoma evansi (T. evansi) during pregnancy. Thirteen pregnant Yankasa ewes were divided into two groups comprising six ewes in group A and seven ewes in group B. Ewes in group A served as the uninfected control while ewes in group B were infected with approximately 1.0 × 106 of T. evansi per ewe through the jugular vein at the second trimester of pregnancy. They were closely monitored for trypanosomosis from the time of infection up till parturition. One ewe from each group was humanely sacrificed 10 days postpartum and examined for pathological changes. At postmortem, no gross lesion was seen in the infected and control ewes and their placenta. Histologically, there were no changes on the placenta, reproductive tract (ovary, oviduct, uterus, cervix), and viscera organs (liver, lungs, heart, kidney, and spleen) of both infected and control ewes. However, the infected ewe had histopathological changes in the hypothalamus characterized by neuronal degeneration and microglial infiltration, while in the pituitary gland, there was mononuclear cell infiltration. The thyroid gland was infiltrated by inflammatory macrophages and lost its glandular secretions. All these histopathological changes were absent in the uninfected ewe, suggesting that T. evansi is capable of disrupting the endocrine function of reproduction in Yankasa ewes.