Anxiety disorders are the most common postpartum psychiatric conditions, yet limited research exists on the prevention of postpartum anxiety and obsessive-compulsive disorder (OCD). Postpartum anxiety leads to significant problems in both mother and child, such as maternal depression, difficulty breastfeeding, interference with parent-infant bonding, and childhood anxiety. In the current study, we tested the feasibility, acceptability, and initial efficacy of an Internet-delivered postpartum anxiety and OCD prevention program, “Preventing Postpartum Onset Distress” (P-POD), in a sample of 15 pregnant women in their third trimester. Geared toward at-risk pregnant people, P-POD includes seven 30-minute educational, interactive modules that teach skills derived from cognitive-behavioral treatment for anxiety and OCD. P-POD also includes three additional modules for partners, with strategies for supporting their partners. Findings suggest that P-POD is acceptable and feasible. Participants experienced reductions in postpartum anxiety risk factors. However, this was a small, open-trial pilot study with a relatively homogeneous sample. Future research should compare P-POD to an active control condition, use more diverse samples, include qualitative interviews, and assess symptoms postpartum.