Background: Laparoscopic techniques, having rapidly increased in popularity because of its various benefits. They are widely used in day-case surgical operations and extensively published issue. However, postoperative nausea vomiting (PONV) is a commonly observed phenomenon after laparoscopic procedures. Its occurrence can increase with anesthetic techniques. Despite that the use of propofol and new low solubility inhalation anesthetics lead to faster induction and recovery, their effects on PONV is not sufficiently known. Therefore, in this study, we aimed to compare the effects of different anesthetic drugs on recovery characteristics and PONV. Methods: After their informed consent, 300 ASA I-III patients scheduled for laparoscopic cholecystectomy were investigated in this study. Anesthesia was induced by fentanyl 1.5 μgkg, midazolam 0.03 mgkg , propofol 1.5 mgkg and vecuronium 0.01 mgkg for all patients. Anesthesia was maintained with desflurane in group D (n=100), sevoflurane in group S (n=100) and propofol infusion in group P (n=100), beside 50 % N2O/O2 ventilation. All patients were given 4 mg ondansetron and 8 mg dexamethazone iv for preventing PONV, ten minutes before the end of surgery. At the end of the operation, times for extubation, eye opening, orientation, sitting and walking, and the need of ondansetrone in post anesthetic care unit were recorded. Also, PONV was observed and recorded as early period (first 4 hours) and late period (4-24 hours). Results: Extubation and eye opening times were meaningfully lower in group D. However, no significant differences were observed in orientation, sitting and walking times and PONV among the groups. We recognize that all the patients who had PONV were women and it has been found that there is a correlation between PONV and body weight. Conclusions: As a conclusion, even tough there were no statistically significant differences among the groups on PONV, the number of patients who had PONV in group P was lower. Early recovery time was shortest in group D, while delayed recovery time had no differences. It may be said that these anesthetic drugs have no statistically significant difference for PONV and delayed recovery.