Background: Liver resection in cirrhotic patients is associated with higher rates of morbidity and mortality. On the other hand, the laparoscopic approach for hepatocellular carcinoma (HCC) resections has been associated with better perioperative outcomes, including less blood loss, shorter length of hospital stay and reduced postoperative complications. The aim of this study is to describe the perioperative Results of laparoscopic hepatectomy for preoperative suspected HCC in our center. Methods: We performed a case series study. Between August 2006 and August 2018, all patients undergoing laparoscopic hepatectomy for preoperative suspected HCC were included. All clinical records were reviewed, registering information regarding to age, gender, comorbidities and chronic liver failure status. We also registered the size of the tumor on preoperative imaging, alpha-fetoprotein (AFP) levels, type of liver resection, intraoperative red blood cells transfusions, operative time, conversion rates, postoperative complications (according to Clavien-Dindo classification) and mortality, reintervention rates, postoperative length of stay, readmissions and pathology. Descriptive statistics were used to analyze the Results. Results: A total of 20 laparoscopic liver resections (LLR) for suspected HCC were performed in the study period. The median age of the group was 68 years (19–82) and 70% (N = 14) of the patients were men. 60% (N = 12) and 30% (N = 6) had hypertension and type 2 diabetes, respectively. 80% (N = 16) had chronic liver failure and, among them, 87,5% (N = 14) were Child-Pugh A classification. The median size of the tumor, measured in preoperative imaging, was 3,3 cm (1–11) and the median of AFP was 4,55 ng/mL (0,7-26,9). 50% (N = 10) of the patients underwent non-anatomic liver resections, 15% (N = 3) right hepatectomies, 10% (N = 2) left lateral segmentectomies and 25% (N = 5) other types of resections. 20% (N = 4) needed intraoperative red blood cells transfusions. The median operative time was 120 min (45-420). 20% (N = 4) of cases were converted to open surgery, mostly because of technical difficulties during dissection. 30% (N = 6) of patients had postoperative complications, one of them had Clavien-Dindo ≥ 3 classification. None of the patients presented postoperative liver failure, need for reintervention nor mortality. The median length of hospital stay was 7 days (3-31) and the readmission rate was 15% (N = 3). Pathology confirmed hepatocellular carcinoma in 65% (N = 13) of cases, fibrolamellar hepatocellular carcinoma in 5% (N = 1), dysplastic nodules in 10% (N = 2), focal nodular hyperplasia in 5% (N = 1), liver abscess with intrahepatic lithiasis in 5% (N = 1) and liver cirrhosis in 5% (N = 1). There was one missed pathology data (5%). Of the confirmed hepatocellular carcinoma cases, 71,4% (N = 10), 14,3% (N = 2) and 14,3% (N = 2) were T1, T2 and T3, respectively, according to the classification of the American Joint Committee on Cancer (TNM) seventh edition. Among them, 85,7% (N = 12) had negative margins. Conclusion: In our experience, laparoscopic liver resection for preoperative suspected hepatocellular carcinoma is a feasible technique with relatively low conversion and intraoperative transfusion rates. Median operative time is similar to reports made by other groups. Despite the high rate of complications (30%), only one patient presented major postoperative morbidity (Clavien-Dindo 3a). No mortality was seen in the group. Pathology analysis confirmed the suspected diagnosis in 70% of the cases, with a high rate of negative margins.