Introduction Routine usage of opioids to manage pain in the post-operative period is commonplace following many orthopaedic procedures. As the trends of opioid abuse and addiction have been primarily linked to an increase in opioid prescriptions, more attention has been focused on reducing opioid prescriptions by managing postoperative pain via alternative methods. The objective of this study was to determine if cryoneurolysis within three months prior to total knee arthroplasty (TKA) resulted in reduced opioid consumption postoperatively. Materials and Methods An IRB approved retrospective review of 183 patients who underwent primary TKA between August 2022 and February 2023 was conducted. The primary outcome was postoperative opioid usage was compared between patients who received cryoneurolysis within three months prior to TKA compared with patients who did not receive cryoneurolysis preoperatively. Secondary outcomes included postoperative knee range of motion (ROM) and referral to physical therapy. Results No statistically significant difference was observed in postoperative opioid consumption for patients who underwent cryoneurolysis prior to TKA compared with patients who did not undergo cryoneurolysis prior to surgery. Discussion Although cryoneurolysis within three months prior to TKA failed to produce a statistically significant decrease in postoperative opioid consumption, the lead author’s preoperative treatment pathway did result in overall reduction in opioid consumption compared to previously published studies. Conclusion The results of this study suggest that cryoneurolysis within three months prior to TKA does not reduce patient postoperative opioid consumption.