Understanding of kidney function decline (KFD) after pelvic exenteration (PE) for colorectal cancer remains limited, and the effects of a long ileal conduit (IC) on kidney disorders are unclear. The aim of this study was to investigate long-term kidney function following PE in colorectal cancer and to evaluate the effects of IC length on KFD. This was a retrospective, single-centre cohort study. KFD was defined as a decline in estimated glomerular filtration rate (eGFR) of ≥30% compared with preoperative data. IC length was measured from a postoperative computed tomography scan. The primary endpoint was the number of patients with KFD 5 years after surgery. The rate of decline of eGFR, cumulative KFD incidence and correlation between IC length and rate of decline of eGFR were also analysed. The patients were divided into two groups (short IC and long IC) based on an IC length of 20 cm. Forty-three patients were included in the analysis. Fourteen (33%) and 29 (67%) patients were included in the short- and long-IC groups, respectively. The long-IC group was significantly more likely to be diagnosed with KFD within 5 years than the short-IC group (51% vs. 14%, p = 0.023). Multivariate analyses revealed that a longer IC was identified as an independent risk factor for KFD (hazard ratio 4.140, 95% CI 1.035-16.560, p = 0.045). Pearson's correlation and linear regression analyses demonstrated a significant association between IC length and rate of decline of eGFR (r = 0.466, p = 0.002). A significant number of patients with colorectal cancer have decreased kidney function after PE. A longer conduit may impair kidney function.
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