Postmenopausal Phase Research Articles

Effectiveness of Eccentric Exercise Training on Chronic Achilles Tendinopathy in Postmenopausal Women

Background: In the Postmenopausal phase, there is a drastic reduction in estrogen levels which may alter tendon metabolism and production of different growth factors, resulting in chronic tendon disorders or tendon rupture. Achilles tendinopathy predominantly affects athletes, but it may also impact individuals with sedentary lifestyles, especially women in their postmenopausal stage. We studied the effectiveness of eccentric exercise training on chronic Achilles tendinopathy in postmenopausal women. Methods: 31 females (aged 45-60, average age 51, BMI 27.6 ± 4.7, range 22.9- 32.3) in their postmenopausal phase with clinical diagnosis of chronic unilateral Achilles tendinopathy both insertional and mid-portion were assessed for pain and functional outcomes with VAS (on rest and on activity ) and VISA-A questionnaire before commencing the exercise and after completion of the training after a duration of 4 weeks. Results: Participants showed an acute improvement in pain on rest and activity and the VISA-A score post-intervention. There was no significant difference in the pre- and post-score on the VAS scale and the VISA- Questionnaire. The mean VAS scale score on rest was 3.580 pre-intervention and 2.903 post-intervention, while the VAS scale score (on activity) was 7.451 pre-intervention which reduced to 6.096 post-intervention. The mean VISA-A score pre-intervention was 39.80, and post-intervention was 46.35. Conclusion: Postmenopausal women suffering from chronic Achilles tendinopathy showed a significant result through training with an eccentric exercise program KEYWORDS: Achilles tendon, Postmenopausal women, Eccentric exercises.

LITERATURE REVIEW: TERAPI KOMPLEMENTER UNTUK MENINGKATKAN KUALITAS HIDUP WANITA PREMENOPAUSE

Premenopause is a transitional period experienced by women when they are about to enter menopause. At this stage, a woman will experience a decrease in the hormone estrogen, giving rise to premenopausal syndrome. Common symptoms of premenopausal women due to changes in body systems manifest in complaints in the form of hair loss easily, irritability or sensitivity, insomnia, frequent sweating, and decreased sex drive. These changes and symptoms occur around 2-3 years before menopause. The prevalence of depression and anxiety in women will increase when entering the premenopausal and postmenopausal phases. A study in China described depressive symptoms experienced by women increasing from 14.5% (premenopausal) to 19.6% in the postmenopausal period. The prevalence of anxiety symptoms increases from 3.1% (premenopausal) to 7.4% in the postmenopausal period. This type of research is a literature review. Data is accessed from various existing database sources such as; Google Scholar, PubMed, Science Direct, Sage Pud, ProQuest. Literature reviewed in the range of 2013 to 2023. The main topic search keywords are; complementary, premenopausal, anxiety, quality of life, woman, psychoeducation. The results of this study concluded that providing complementary therapy for premenopausal women has an effective effect on improving quality of life and reducing anxiety in premenopausal women. According to the researchers' analysis, complementary therapy can reduce vasomotor symptoms, reduce stress and depression in women.

Pancreastatin deteriorates hepatic lipid metabolism via elevating fetuin B in ovariectomized rats

Hepatic steatosis is an important mstetabolic complication in women encountering postmenopausal phase of life. Pancreastatin (PST), has previously been investigated in diabetic and insulin resistant rodents. The present study highlighted the role of PST in ovariectomized rats. Female SD rats were ovariectomized and subsequently fed high fructose diet for 12 weeks. PST inhibitor peptide was intraperitoneally administered for 14 days and further examined for insulin resistance, glucose intolerance development, body mass composition, lipid profile detection and hepatic fibrosis. Gut microbial alterations has also been investigated. Results showed development of glucose intolerance in high fructose fed ovariectomized rats with reduced level of reproductive hormones including estradiol and progesterone. Enhanced lipid production was detected in these rats as they showed increased triglycerides, lipid accumulation in liver tissue (determined by HE staining, Oil Red O staining, Nile Red staining). Sirius Red and Masson's trichome analysis depicted positive results for fibrosis development. We also found gut microbiota alterations in fecal samples of these rats. Furthermore, PST inhibition decreased the expression of hepatic Fetuin B and resumed gut microbial diversity. PST deregulates hepatic lipid metabolism which leads to altered expression of Fetuin B in liver and gut dysbiosis in postmenopausal rats.

INVESTIGATIONS ON OSTEOPOROTIC FRACTURE RISK ASSESSMENT AMONG SOUTH INDIAN WOMEN

Background: Osteoporosis results in an increased risk of fracture among aging women. A strong connection exists for bone health with tooth loss, menopause, diet, BMI and hysterectomy. Purpose: To study the impact of heel BMD with age, BMI, menopausal status, hysterectomy and tooth loss among people living in Chennai metropolitan neighborhood. Materials and Methods: The study involved ([Formula: see text], age: [Formula: see text] years) women, which included women with normal BMD ([Formula: see text] = 35, age: [Formula: see text] years), Osteopenia ([Formula: see text], age: [Formula: see text] years) and Osteoporosis ([Formula: see text], age: [Formula: see text] years). All the participants underwent BMD assessment at their right heel using an Ultrasound densitometer system (Model: CM-200, Manufacturer: FURUNO ELECTRIC CO. LTD., Japan). The subjects were classified into various subgroups based on BMD, age, Menopausal status, hysterectomy and tooth loss. Results: The mean age of women attaining menopause and those undergoing hysterectomy are [Formula: see text] years and [Formula: see text] years, respectively. The decrease of heel BMD was very prominent among women having more than two tooth extracted, menopause and hysterectomy. It was found that approximately 90% of the studied population were suffering from either osteopenia or osteoporosis in their post-menopausal period. Conclusion: Women aged above 50 years are at greater risk of osteoporosis due to post-menopausal phase, high probability of undergoing hysterectomy and tooth loss. Therefore, women should ensure sufficient consumption of calcium rich diet in their entire life cycle to ensure a healthy livelihood.

Distinct dietary risk factors for incident osteoporotic fractures in early and late postmenopausal phase women.

Available evidence on favorable nutritional factors for preventing osteoporosis remains controversial. Considering the recent increases in life expectancy, we investigated the relationship between incident osteoporotic fractures and dietary habits in early and late postmenopausal phase women. Subjects were Japanese postmenopausal outpatients recruited at a primary care institution in Nagano Prefecture (Nagano Cohort Study). Patients with critical or acute illness or secondary osteoporosis were not included in this study. In total, 1,071 participants were prospectively followed for a mean of 5.8years. The cohort was divided into early (≤ 70years) and late (> 70years) postmenopausal phases based on median age. Dietary nutrient intake was estimated by the food frequency questionnaire method. According to baseline nutrient intake characteristics, we focused on protein/energy and Ca/NaCl intake ratios, which were also divided by the median values. Kaplan-Meier plots revealed a significantly higher occurrence of fractures for the high protein/energy intake group in early postmenopausal subjects (P = 0.009), whereas the low Ca/NaCl intake group in late postmenopausal subjects exhibited a significantly earlier occurrence of fractures (P = 0.002). Multivariate Cox regression uncovered significant independent risks of higher protein/energy (HR 1.35; 95% CI 1.04-1.74) and lower Ca/NaCl (HR 0.79; 95% CI 0.63-0.99) intake ratios for incident osteoporotic fractures in the early and late postmenopausal cohorts, respectively. Distinct dietary risk factors for osteoporotic fractures were identified in early and late postmenopausal phase women. Appropriate nutritional guidance according to patient age will be important for maintaining bone health and quality of life.

Современные возможности лечения вульвовагинальной атрофии: гормональные методы и лазерная модулирующая терапия

Vulvovaginal atrophy (VVA) is a common but underreported condition in real clinical practice caused by decreased estrogenization of the vaginal tissues. The prevalence of VVA in the postmenopausal phase is at least 50%, and according to some data, 80%. Not only patients, but also some physicians consider VVA as an inevitable part of the aging process, which delays the diagnosis and treatment of genitourinary syndrome of menopause (GSM). Treatment options for GSM are limited by contraindications to local hormone therapy, poor patient compliance, and hormonophobia. In this regard, the search for alternative non-invasive treatment methods is relevant. The search for literature for 2012–2022 was performed in PubMed, CochraneLibrary, Science Direct, and ELibrary databases using the following keywords: vulvovaginal atrophy, genitourinary syndrome of menopause, treatment, CO2-laser, postmenopausal age. Conclusion. Microablative fractional CO2-laser therapy for VVA can relieve symptoms and improve the condition of the vaginal mucosa by enhancing regeneration processes, but high-quality research is needed to study the efficacy and safety of this treatment method. Key words: vulvovaginal atrophy, genitourinary syndrome of menopause, perimenopause, postmenopause, therapy, laser therapy, CO2-laser

A comprehensive review of the bioactive components of sesame seeds and their impact on bone health issues in postmenopausal women.

Sesame seeds perform many therapeutic functions against several health issues especially those related to bones because they possess a rich content of calcium, vitamins, proteins, oil, and carbohydrates. Using the PubMed, ScienceDirect, and Google Scholar databases, we performed a comprehensive search of the literature from 2013 to date on reports related to sesame seeds and their bioactive ingredients. Sesamin, sesamol, sesamolin, and sesamol are the major bioactive lignans found in sesame seeds. Our comprehensive review of the literature revealed the protective role of sesame seeds towards bone health in postmenopausal osteoporosis. It was observed that sesame seeds have a positive impact on postmenopausal women experiencing bone-related problems, i.e. osteoporosis and arthritis. Therefore, this review is focused on exploring the effect of sesame seeds on bone mineralization in women experiencing menopause. Furthermore, to aid balancing the hormones in women after their disturbance by the postmenopausal phase, we highlight the effect of the daily intake of sesame seeds in women. Finally, we conclude that the supplementation of sesame seeds in a regular diet shows a positive impact on the bone health of post-menopausal osteoporosis.

Can precision medicine get us through menopause?

Women spend up to three decades in the post-menopausal phase of life, which is often accompanied by a wide variety of life-disrupting symptoms, including vasomotor symptoms, sleep disturbances, cognitive decline, mood disorders, and metabolic dysfunction.1 Regarding the latter, while ageing associates with weight gain, shifts in body composition, and metabolic dysfunction in both sexes, the abrupt shifts in hormones associated with the menopause transition coincides with a stark increase in metabolic risk,1 resulting in an alarming increase in cardiovascular disease and diabetes prevalence among postmenopausal women.

A Study to assess the menopausal problems among postmenopausal women residing in selected rural and urban areas of Jagadhri, Yamuna Nagar, Haryana

Menopause is one of the most crucial phase of women’s life and can be influenced by various socio demographical factors including age, educational status, age at menarche, smoking status etc. It is the permanent cessation of menstruation for at least 12 consecutive months. Women face lots of menopausal problems (physical, psychological, urogenital etc.) during postmenopausal phase. Thus, the present study mainly focuses on menopausal problems among postmenopausal women in selected rural and urban areas of Jagadhri, Yamuna Nagar, Haryana. Objectives: To assess the menopausal problems among postmenopausal women and to find out the association between menopausal problems and demographic variables. Materials and Methods: A descriptive study design was adopted for the current study. The study was conducted at selected rural and urban areas at Jagadhri, Yamuna Nagar, Haryana. The non-probability convenient sampling technique was used. 100 menopausal women residing in selected rural and urban areas were recruited for the study. The study included women who have attained menopause, who understand Hindi, English and designated language, who are residents of rural and urban areas of Jagadhri, Yamuna Nagar and the study excluded women who are not willing to participate and having any major medical disorder. Self-structured rating scale was used to assess the menopausal problems. Data was analyzed by using SPSS version 16. Results: The study findings show that, majority (59%) of respondents had mild menopausal problems, 41% had moderate menopausal problems and none of woman had severe menopausal problems. It is found that there is significant association between menopause attained and menopausal problems of respondents at 0.05 levels with chi square values (13.394) and p-value (0.000). Conclusion: It is concluded that most of the women were having mild menopausal problems. There is need to provide nursing education, health education programme and awareness to handle the menopausal problems and to ease the sufferings of women.

SCENARIO OF THE OCCURRENCE OF BREAST CANCER IN PREMENOPAUSAL AND POSTMENOPAUSAL PHASES OF WOMEN IN THE SPAN OF THEIR REPRODUCTIVE PERIOD

Background: Breast cancer, nowadays, becoming a commonly exposed disease in women. In India, 27.7% of all new cancers detected in women in the year 2018, were breast cancers. The Objec Objective: tive of the study is to represent the scenario of the occurrence of breast cancer in premenopausal and postmenopausal phases of women in the span of their reproductive period. Methodology: Various studies were searched using Pub-med and Google search engines. These study were analogously mentioned in this paper. Results: Early age at menarche, late age at menopause and every year older at menopause were associated with an increased risk of breast cancer. Conclusion: Breast cancer awareness campaigns may have their roles in prevention of occurrence of the disease.

Abstract P2-11-03: Menstrual phase classification of benign breast tissue using hormone-regulated gene expression and morphology

Abstract Introduction: The use of archived benign breast samples (BBS) for breast cancer risk research is limited by the fact that menstrual luteal phase and menopausal status is either unknown or inaccurate by self-report. As a result, physiologic variation in gene and protein expression cannot be accounted for. We previously showed that morphologic features (PMID: 12481017) and progesterone (P)-related gene expression (PMID: 23512947) in breast specimens can aid in luteal phase classification. Here we report a validation of the concept, in a larger sample size, regarding gene expression, menstrual-specific morphology factors and a combination of both. Methods: BBS were obtained from the contralateral unaffected breast (CUB) of unilateral breast cancer patients and reduction mammoplasty (RM) controls of premenopausal women (n = 81) under IRB approved protocol. Gene expression analysis was performed with 100 ng by qRT-PCR of 21 target genes. Serum concentration of estradiol (E), P, and follicular stimulating hormone (FSH) were measured by enzyme immunoassay and IMMULITE. Subjects were classified using hormone levels as postmenopausal (E< 30 pg/ml and FSH> 30 IU/L) or luteal phase (E>60pg/ml and P>3ng/ml); premenopausal women who did not meet luteal phase hormonal criteria were called non-luteal. A single study pathologist evaluated samples from premenopausal subjects, masked to the menstrual phase of subjects, using histo-morphologic features to categorize subjects as luteal or non-luteal. Gene expression and morphology were evaluated individually and together, through multivariate analysis, for luteal-phase stratification. Receiver operator curve (ROC) analysis was used to assess the accuracy (AUC) for prediction of luteal phase using gene expression, morphology and a combination of both. Results: Our study population, matched by age, included 81 premenopausal subjects (CUB=51, RM=30) with mean age of 42. For luteal phase classification, we identified P-correlated genes; TNFSF11, DI02, and MYBPC1 genes were significantly correlated with serum progesterone levels. ROC analysis results using individual genes, average morphology score and multivariate model is in the table below. The results are reported with the area under the curve (AUC) value along with the confidence interval. The multivariate model consists of the three genes with the average morphology score. Conclusions: We provided preliminary validation for three P-related genes as classifiers of luteal phase status. We find that histomorphologic classification of menstrual phase is more prominent in the RM samples. These findings along with our validation data, for the first time, provide RNA-based classifiers for menstrual phase of BBS, and offer the potential of increasing the robustness and validity of biomarker research by accounting for important physiologic variation in the hormonal milieu of the donor. CUB (n = 51) AUC +/- ciRM (n = 30) AUC +/- ciTNFS11 gene expression0.84 (0.74 – 0.95)0.76 (0.54 – 0.97)DI02 gene expression0.86 (0.75 – 0.96)0.72 (0.49 – 0.96)MYBPC1 gene expression0.80 (0.68 – 0.92)0.67 (0.45 – 0.89)Average morphology score0.67 (0.54 – 0.81)0.87 (0.76 – 0.98)Multivariate model0.89 (0.79 – 0.98)0.948 (0.87 -1.00) Citation Format: Omid Hosseini, Irene Helenowski, Oukseub Lee, Hui Zhang, Jun Wang, Luis Blanco, Seema A Khan. Menstrual phase classification of benign breast tissue using hormone-regulated gene expression and morphology [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-11-03.

Evidence and consensus-based clinical practice guidelines for management of overweight and obesity in midlife women: An AIIMS-DST initiative.

Evidence and consensus-based clinical practice guidelines for management of overweight and obesity in midlife women: An AIIMS-DST initiative.

Menopausal symptoms among middle-aged women and care providers’ readiness to deliver menopausal services: an observational study in Kavrepalanchok, Nepal

Health care needs of menopausal women and availability of corresponding services through health systems are under-researched. This two-stage observational study examined the prevalence of menopausal symptoms among middle-aged women in four rural and semi-urban communities in Kavrepalanchok, Nepal and explored sexual and reproductive health (SRH) care providers’ readiness to provide menopausal health care. We recruited 252 women aged 40–59 years in the pre-, peri- and post-menopausal phases of the menopausal transition, and interviewed 20 SRH primary care providers. The cross-sectional survey provided data on the prevalence of menopausal symptoms, disaggregated by women’s socioeconomic characteristics, health behaviours and biological features, while data on the knowledge, skills and willingness of SRH care providers to deliver menopausal care were derived from interviews. Most women (84.9%) reported experiencing one or more adverse menopausal symptoms. Socioeconomically and geographically marginalised women were more likely to report experiencing severe menopausal symptoms that would require medical assistance than their more privileged counterparts. Sexual and reproductive health service providers were willing, albeit with limited knowledge and skills, to assess menopausal women’s needs and provide menopausal care. They recommended incorporating menopausal care in SRH policies and training and logistics to provide the services. Culturally, economically and geographically marginalised women experienced a higher prevalence of menopausal symptoms. Sexual and reproductive health policies and programmes of the government should expand beyond women of childbearing age or adolescents to include menopausal women’s needs.

Premenstrual Mood Symptoms in the Perimenopause.

This review considers how reproductive aging may impact the trajectory of menstrually related mood disorders (MRMDs) such as premenstrual dysphoric disorder and considers how the treatment of MRMDs might require adjustment as patients approach midlife. The early menopause transition is accompanied by important hormonal changes that may exacerbate existing MRMDs. Indeed, recent research confirms that an important subset of women experiences depressive mood in response to perimenopausal elevations in ovarian hormones. In addition, a subset of women with an MRMD may exhibit an increased mood sensitivity to the ovarian hormone withdrawal that accompanies the late menopause transition and early postmenopausal phase. Though additional research is needed to clarify the trajectory of premenstrual dysphoria in the menopause transition, there is reason to believe that health care providers should be vigilant for a potential worsening of symptoms in perimenopause for women with past or current premenstrual dysphoric disorder.

Regular physical activity reduces the proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase.

Aging in women is characterized by extreme hormonal changes leading them to develop a chronic low-grade inflammation that is linked to the development of systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM). In this scenario, physical activity emerges as an interesting methodology, since it seems to be connected to a decrease in serum levels of some pro-inflammatory cytokines. Nevertheless, most studies evaluate these cytokines in an isolated manner not considering the influence of comorbidities on the responsiveness of participants to the benefits of physical activity. So, this study aimed to assess the influence of physical activity on body composition, anthropometric parameters, lipid profile, and inflammatory markers of diabetic and hypertensive older postmenopausal women. We evaluated 163 women aged from 60 to 80years, diagnosed with T2DM and SAH that were assisted by the Family Health Units in Vitória da Conquista, Bahia, Brazil. The pratice of physical activity was measured by the International Physical Activity Questionnaire with the participants being classified as active or sedentary individuals. Active older women presented better body composition, lipid profile and inflammatory balance. This was connected to a better correlation profile between these factors in active older women, characteristics that were not noticed in sedentary older women. Moreover, IL-17A and the relationship between IL-10 and the other pro-inflammatory cytokines examined was greatly influenced by physical activity. Consequently, physical activity is linked to a global improvement in T2DM and SAH risk factors and with a positive inflammatory modulation in diabetic and hypertensive older women.

Diagnosis and management of the menopause

Menopause is the cessation of menstruation; it typically occurs at around 51 years of age. The postmenopausal phase of life is linked to a variety of health conditions, including osteoporosis, cardiovascular disease and cognitive decline. Beyond symptom control, hormonal replacement therapy (HRT) reduces the incidence of chronic health conditions. Some unfounded concerns and misunderstanding about the risks of HRT contribute to a low uptake of HRT, currently around 10% of menopausal women. This article highlights the symptoms of menopause and treatment options available. As the majority of menopause management occurs in primary care, a good understanding of the risks and benefits is paramount when guiding patients to make informed decisions about the treatment options.

Sonographic Abnormalities of Thyroid Gland in pre and post-menopausal women

Background: Women that are over 50 years are usually diagnosed by thyroid disorders. The prevalence of Thyroiditis, thyroid cancer, found more under postmenopausal women than premenopausal. In the postmenopausal phase the prevalence of biochemical (or subclinical) hypothyroidism rising from 10% to 20%, or increases steadily with age in women. The study results show an enlargement in the activities of Thyroid stimulating hormone among menopausal women. Aim: To compare the sonographic findings of thyroid gland in before and after-menopausal women. Method: An Analysis of scientific literature concerning the correlation of Sonographic abnormalities of thyroid gland in pre and post-menopausal women was done. Different platforms including medical journals, books and online resources (e.g., PubMed, Google Scholar & Medline) were explored to find the relevant data using the mesh Terms: Thyroid gland, premenopausal and postmenopausal women, etc. The main focus was given to the latest data published in the last 10 years. Key words: Thyroid gland, premenopausal and postmenopausal women.

Obesity-associated cardiovascular risk in women: hypertension and heart failure.

The pathogenesis of obesity-associated cardiovascular diseases begins long prior to the presentation of a cardiovascular event. In both men and women, cardiovascular events, and their associated hospitalizations and mortality, are often clinically predisposed by the presentation of a chronic cardiovascular risk factor. Obesity increases the risk of cardiovascular diseases in both sexes, however, the clinical prevalence of obesity, as well as its contribution to crucial cardiovascular risk factors is dependent on sex. The mechanisms via which obesity leads to cardiovascular risk is also discrepant in women between their premenopausal, pregnancy and postmenopausal phases of life. Emerging data indicate that at all reproductive statuses and ages, the presentation of a cardiovascular event in obese women is strongly associated with hypertension and its subsequent chronic risk factor, heart failure with preserved ejection fraction (HFpEF). In addition, emerging evidence indicates that obesity increases the risk of both hypertension and heart failure in pregnancy. This review will summarize clinical and experimental data on the female-specific prevalence and mechanisms of hypertension and heart failure in women across reproductive stages and highlight the particular risks in pregnancy as well as emerging data in a high-risk ethnicity in women of African ancestry (AA).

Histological and morphometrical features of endometrial polyposis complicated with uterus bleeding. Review and clinical data

Endometrial polyposis is a condition that affects the lining of the endometrium or the uterus and it is seen in 1-17% of women in their reproductive years. The symptoms are often uterine bleeding which can occur as menorrhagia and the polyps can be sessile or pedunculated. This pathology can also arise in women who are in the post-menopausal phase and the exact pathogenesis of the pathology is not known but there are theories that shed light on how this may occur. We conducted a study in which we took 70 surveyed women with endometrial polyps which were complicated by uterine bleeding to determine their morphological types and identify the relationship between the types of polyps and the frequency of uterine bleeding.

GAMBARAN PENGETAHUAN PREMENOPAUSE TENTANG PERUBAHAN FISIK DALAM MENGHADAPI MASA MENOPAUSE DI DUSUN MANNYOI DESA TAMANNYELENG KECAMATAN BAROMBONG KAB. GOWA

Premenapause Knowledge Overview About Physical Period Facing Menopause Period In Mannyoi Village Tamannyeleng Village Barombong District Gowa Regency 2018. (guided by HJ Sitti Mukarramah and Agustina Ningsih) Changes that occur during menopause, women experience a peak complaint while in the post-menopausal phase of this period lasts 6-7 years after menopause. At this time estrogen levels after the low point in accordance with the state of the art and accompanied by the deterioration of body condition. This study aims to determine the characteristics of respondents and description of premenopausal knowledge about physical changes in the face of menopause In Mannyoi Village Tamannyeleng Village District Barombong Gowa District. Samples were taken from primary data, all mothers aged 40 to 55 years old in Mannyoi Village Tamannyeleng Village Barombong District of Gowa regency that fit the criteria in sampling, during the period of February to May 2018, the type of research is descriptive with the method used is through a questionnaire with cross sectional approach, with a sample size of 50 respondents. Characteristics of respondents based on the level of education is elementary education of 41 respondents (82%), SMP of 8 respondents (16%) and the high school education of 1 respondent (2%) and characteristics of respondents by age, 40-49 years age of 37 74%) and age> 50 years at 13 (26%). Good knowledge as many as 34 people (68%), while knowledgeable enough as much as 9 people (18%) and who have less knowledge as much as 7 people (14%). One of the main concerns of mother's knowledge is the intervention of health workers and information from the surrounding community Keywords: Knowledge, Premenopause