Nasomaxillo-acrodysostosis or Binder’s syndrome in a patient with a cleft lip and palate anomaly is infrequent. This case report underscores a unique surgical outcome achieved through an integrated orthopaeddontic and maxillofacial surgical approach within a multidisciplinary team. The treatment, initiated during a significant paediatric growth phase, was remarkably successful during the orthopaeddontic phase. The result obtained due to the successful early orthopaeddontic intervention significantly altered the initial plan for major midfacial orthognathic surgical reconstruction. As a result, the child born with this twin facial anomaly experiences a more typical development trajectory with fewer disruptions from extensive oro-facial reconstructions. The case underscores the importance of early maxillary expansion across multiple dimensions during the critical paediatric growth period. This approach was pivotal in achieving a positive outcome, ultimately reducing the need for major invasive surgical procedures. The success of the treatment was also attributed to the dedicated collaboration among the healthcare professionals, the patient’s commitment and the family’s strong support.