You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation, Vascular Surgery II1 Apr 20122270 POSTTRANSPLANT DIABETES MELLITUS IN ADULT RENAL TRANSPLANT RECIPIENTS: INCIDENCE, CLINICAL CHARACTERISTICS, TACROLIMUS PHARMACOKINETICS, AND RELATED GENOMIC POLYMORPHISMS Kazuyuki Numakura, Shigeru Satoh, Norihiko Tsuchiya, Mitsuru Saito, Shinya Maita, Takashi Obara, Takamitsu Inoue, Shintaro Narita, Yohei Horikawa, Hideaki Kagaya, Masatomo Miura, and Tomonori Habuchi Kazuyuki NumakuraKazuyuki Numakura Akita, Japan More articles by this author , Shigeru SatohShigeru Satoh Akita, Japan More articles by this author , Norihiko TsuchiyaNorihiko Tsuchiya Akita, Japan More articles by this author , Mitsuru SaitoMitsuru Saito Akita, Japan More articles by this author , Shinya MaitaShinya Maita Akita, Japan More articles by this author , Takashi ObaraTakashi Obara Akita, Japan More articles by this author , Takamitsu InoueTakamitsu Inoue Akita, Japan More articles by this author , Shintaro NaritaShintaro Narita Akita, Japan More articles by this author , Yohei HorikawaYohei Horikawa Akita, Japan More articles by this author , Hideaki KagayaHideaki Kagaya Akita, Japan More articles by this author , Masatomo MiuraMasatomo Miura Akita, Japan More articles by this author , and Tomonori HabuchiTomonori Habuchi Akita, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2448AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The present study investigated the incidence of posttransplant diabetes mellitus (PTDM) and calculated the risk of developing PTDM under a tacrolimus (TAC) and mycophenolate mofetil (MMF)-based immunosuppression based on clinical characteristics, risk factors, TAC-pharmacokinetics (PK), and genomic polymorphisms related to TAC-PK, cytokines and diabetes mellitus (DM). METHODS One hundred twenty-three non-diabetic adult renal allograft recipients (male 72, female 51) transplanted between January 2001 and October 2009 were studied. Patients with continuous high plasma glucose levels, over 6.5mg/dl of hemoglobin A1c, or requiring insulin and/or oral anti-diabetic agents for more than 3 months 1-year after transplantation were diagnosed as having PTDM. Fifty genomic polymorphisms were assessed. RESULTS After transplantation, 19 recipients (15.4%) developed PTDM. Older age (p=0.030) and high body mass index (BMI) (p=0.038) at the time of transplantation were associated with the development of PTDM. There was no relationship between the development of PTDM and other clinical parameters, TAC-PK or its related genomic polymorphisms. The frequencies of PTDM were significantly higher in patients with the adiponectin T45G TT genotype than in those with the G allele (p= 0.038). On multivariate analysis, older age (>50 years old), high BMI (>24) and adiponectin T45G TT genotype were risk factors for the development of PTDM. CONCLUSIONS The incidence of PTDM in our cohort was 15.4%. Older age and high BMI were clinical risk factors for PTDM. The adiponectin T45G TT genotype may influence the occurrence of PTDM, but TAC-PK and related genes did not. These findings might contribute to elucidating the mechanism of PTDM and predict a patient's risk for developing PTDM. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e916 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kazuyuki Numakura Akita, Japan More articles by this author Shigeru Satoh Akita, Japan More articles by this author Norihiko Tsuchiya Akita, Japan More articles by this author Mitsuru Saito Akita, Japan More articles by this author Shinya Maita Akita, Japan More articles by this author Takashi Obara Akita, Japan More articles by this author Takamitsu Inoue Akita, Japan More articles by this author Shintaro Narita Akita, Japan More articles by this author Yohei Horikawa Akita, Japan More articles by this author Hideaki Kagaya Akita, Japan More articles by this author Masatomo Miura Akita, Japan More articles by this author Tomonori Habuchi Akita, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...