Post-tensioned unbonded tendons are widely used in flat slabs/plates when there is a demand for large span lengths, durable tendons and a reduction in the weight of structure. For post-tensioned flat slab/plates, different tendon layouts have been discussed in the literature. It is vital to compare the structural response (i.e., deflection and stresses) and the clashing of tendons of the proposed tendon layouts in the literature to select an appropriate layout. Hence, this study focuses on the analysis of three different six-panel flat plates (i.e., panel sizes: 6 m × 6 m, 9 m × 6 m and 11 m × 6 m) with five different tendon layouts, using computer programs ADAPT-Floor Pro and FEM-Design 17, based on linear finite element (FE) analysis. Short-term/long-term deflection and stress due to service load obtained from the computer programs has also been compared, to highlight the differences. Ultimate bending moment of resistance was calculated theoretically for different layouts and compared. Results from the analysis show that, when a higher portion of tendons is concentrated instead of distributed, stresses caused by other structural loads are counteracted best. The layout with all tendons concentrated also has the best results in terms of deflections.