Background: Acute poisoning is a major health problem leading to emergency department admission and inducing significant patient morbidity and mortality throughout worldwide. Nurse's performance playsan importantrole in the management of acute poisonings. Aim of the study: Determine the effect of emergent nursing educational program on nurses’ performance for patients with acute poisoning. Design: A quasi- experimental design was utilized in this study. Subjects and method: Data were collected from all nurses (27 nurses from Tanta University Poisoning Control Center and 10 nurses from Elmanshawy General Hospital) affiliated to affiliated to ministry of health. Tools: Two tools were used to collect data: Tool (I); Nurses’ Structured Interview Scheduled Sheet part one: socio-demographic characteristics of nurses, part two: structured nurses’ knowledge interview questionnaire, Tool (II); nurses' observational checklist about emergent nursing intervention of acutely poisoning patient. Results: the present studyrevealed that there was a significant improvement in the mean scores of the total level of knowledge and practice immediately and one-month post program implementation in both studied groups at P < 0.05. with only significant difference between two groups in pre-program implementation regarding total practice at P < 0.05. Conclusion: The study findings revealed that nurses' performance of emergent intervention for patient with acute poisoning had improved after application of educational program. Recommendation: It is recommended to nurse's instructor to distribute guideline booklet with knowledge and practices about emergent intervention for poisoning in centers and continuous in-service educational program.