Aim: To identify additional risk factors for maternal mortality (MM) in critical obstetric conditions (COC) and opportunities for their reduction. Design: Retrospective observational sample study. Materials and methods. Analysis of 2508 cases entered into the Register of COC of the module “Obstetrics and Neonatology” of the Vertically Integrated Medical Information Systems of the Ministry of Health of Russia in the period from 01.01.2021 to 12.31.2022 in the Volga Federal District. “Patient's age”, “leading criterion of COC in the development of symptoms”, “obstetric status at the time of development of COC symptoms”, “level of obstetric care” indicators analyzed and their influence on the probability of death were studied. A total of 59 (2.7%) deaths were registered: 49 (83.1%) MM and 10 (16.9%) deaths of women during pregnancy, childbirth and the postpartum period who did not meet the criteria. 8 deaths from external causes were excluded from the analysis. After excluding patients with COVID-19, the authors identified 2201 (87.8%) cases to analyze. Results. The risk of MM increased in the presence of jaundice in preeclampsia by 70.047 times (95% confidence interval (CI): 6.206–790.68; p < 0.001), ketoacidosis by 12.306 times (95% CI: 1.415–106.983; р = 0.023), cardiac arrest by 6.478 times (95% CI: 2.945–14.251; p < 0.001), pulmonary edema any etiology by 4.123 times (95% CI: 1.215–13.990; р = 0.023), predicted or ongoing difficult tracheal intubation by 526.500 times (95% CI: 25.567–10842.032; p < 0.001), cardiopulmonary resuscitation by 11.488 times (95 % CI: 2.170–60.824; р = 0.004), anaphylactic shock by 25.204 times (95% CI: 1.779–357.153; р = 0.017). The presence of severe preeclampsia did not significantly affect the likelihood of death (HR = 0.833; 95% CI: 0.643–1.080; p = 0.169). With the development of COC symptoms, the risk of death in a pregnant woman was 5.569 times lower than in a woman in labor, and in a postpartum woman it was 6.600 times lower. In a tertiary hospital, the probability of death was 14.226 times less. Conclusion. Certain extragenital pathology leading to the development of COC is the main risk factor for MM. Obstetric pathology is much more common, but due to the competence of obstetrician-gynecologists in secondary and tertiary obstetric hospitals, the risk of death, is significantly reduced. At the same time, at each stage of care, indications for routing the patient to a higher-level hospital should be taken into account in order to provide adequate medical care for extragenital diseases. Keywords: critical obstetric conditions, maternal mortality, mortality risks.