Global environmental and health issues such as climate change and the COVID-19 pandemic have highlighted the weaknesses of current urban systems, including the poor availability and accessibility of green and public spaces in cities. Nature-based Solutions are configured as promising solutions to increase the resilience and health of the built environment by addressing climate and pandemic issues, promoting the psycho-physical well-being of users and proposing solutions for the protection of the environment and ecosystems. Following a systematic review of the scientific literature using the PRISMA methodology, this study aims to provide a taxonomic framework for Nature-based Solutions for the built environment that is applicable to the urban and building scales, highlighting key benefits in addressing pandemic and climate challenges and achieving urban resilience. This framework proposes a holistic and multifunctional approach that will prove to be a useful tool for researchers and policy makers to incorporate greening strategies into urban regeneration and redevelopment processes. The application of Nature-based Solutions still seems to be limited. It is therefore necessary to raise awareness of this issue among citizens and policy makers and to promote close co-operation between the different actors in territorial decision-making processes.