The quantity of teleworkers had already been rising in various work fields even prior to the COVID-19 pandemic. However, it was not until the pandemic that it spread to other sectors such as the industrial sector. There are still few studies looking at telework’s impact on this important sector. This article is intended to discuss: (1) the extent of teleworking in manufacturing, (2) its adjustment to the industrial sector (challenges and benefits), and (3) its prospects for the future. To this end, 31 in-depth interviews have been conducted with four Plant Managers and seven Human Resource Directors of 11 industrial companies in Burgos (Spain) and surroundings, as well as 20 of their workers. Pre-pandemic teleworking was only active in one of the enterprises and now there are workers that work remotely in 9 out of 11. All interviewees agreed that teleworking will gradually expand. The study shows concerns and challenges when it comes to communication, trust, control, and productivity. It highlights the importance of establishing clear policies on teleworking and how to deal with remuneration, expense reimbursements, and equity between teleworkers and on-site workers. Overall, industrial-sector teleworking has brought positive results in terms of productivity and job satisfaction levels, but it has also resulted in new demands on aspects such as ergonomics, negative habits (food and physical inactivity), communication, and work–life balance.