<i>To the Editor</i>.—We appreciate the opportunity of replying to Dr. Jaffe's criticism of our paper entitled "Carbon Dioxide Narcosis: An Unusual Complication of Postnasal Packing." We admit the diagnosis of carbon dioxide narcosis is ultimately made by an analysis of an arterial blood sample for PCO<sub>2</sub>, PO<sub>2</sub>and pH. In our case, as stated in the paper, the diagnosis was made on the basis of clinical manifestations: A change in the mental state of the patient with marked impairment of alveolar ventilation and mild congestive heart failure, cyanosis, and development of coma after administration of oxygen. The primary symptoms and findings of CO<sub>2</sub>intoxication are those of a neurologic disorder. They may vary in both character and severity, depending upon the degree of hypercapnea. The patient may complain of headache and somnolence. As CO<sub>2</sub>intoxication progresses, the patient develops weakness, lassitude, instability, marked mental
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